Faculty

Jennifer L Orthmann-Murphy, MD, PhD

faculty photo
Assistant Professor of Neurology
Department: Neurology
Graduate Group Affiliations

Contact information
Department of Neurology
Hospital of the University of Pennsylvania
3 Gates
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-662-3606
Lab: 215-898-8282
Education:
B.A. (Biological Basis of Behavior with distinction (History minor))
University of Pennsylvania, 2001.
Ph.D. (Neuroscience)
University of Pennsylvania Perelman School of Medicine, 2007.
M.D. (Combined Degree Program)
University of Pennsylvania Perelman School of Medicine, 2010.
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Description of Research Expertise

Research Interests: The Orthmann-Murphy laboratory studies the dynamic role of glial cells in acquired and inherited demyelinating disease.

Key Words: glia, myelin, multiple sclerosis, demyelination, remyelination

Techniques: multiphoton imaging

Selected Publications

Laura A Adang, Joshua L Bonkowsky, Jaap Jan Boelens, Eric Mallack, Rebecca Ahrens-Nicklas, John A Bernat, Annette Bley, Barbara Burton, Alejandra Darling, Florian Eichler, Erik Eklund, Lisa Emrick, Maria Escolar, Ali Fatemi, Jamie L Fraser, Amy Gaviglio, Stephanie Keller, Marc C Patterson, Paul Orchard, Jennifer Orthmann-Murphy, Jonathan D Santoro, Ludger Schöls, Caroline Sevin, Isha N Srivastava, Deepa Rajan, Jennifer P Rubin, Keith Van Haren, Melissa Wasserstein, Ayelet Zerem, Francesca Fumagalli, Lucia Laugwitz, Adeline Vanderver: Consensus guidelines for the monitoring and management of metachromatic leukodystrophy in the United States. Cytotherapy 26 (7): 739-748, July 2024.

Aaron Baldwin, Juliette Copeland, Meron Azage, Laynie Dratch, Kelsey Johnson, Rachel A Paul, Defne A Amado, Michael Baer, Andres Deik, Lauren B Elman, Michael Guo, Ali G Hamedani, David J Irwin, Aaron Lasker, Jennifer Orthmann-Murphy, Colin C Quinn, Thomas F Tropea, Steven S Scherer, Russell T Shinohara, Roy H Hamilton, Colin A Ellis: Disparities in genetic testing for neurologic disorders. Neurology 102 (6): https://doi.org/10.1212/WNL.000000000020916, March 2024.

Dratch L, Azage M, Baldwin A, Johnson K, Paul RA, Bardakjian TM, Michon SC, Amado DA, Baer M, Deik AF, Elman LB, Gonzalez-Alegre P, Guo MH, Hamedani AG, Irwin DJ, Lasker A, Orthmann-Murphy J, Quinn C, Tropea TF, Scherer SS, Ellis CA. : Genetic testing in adults with neurologic disorders: indications, approach, and clinical impacts. J Neurology 271 (2): 733-747, Feb 2024.

Felipe J.S. Jones and Jennifer Orthmann-Murphy: Clinical Reasoning: A 26-year-old woman with chronic progressive gait dysfunction Neurology in press 2024.

Anjana Sevagamoorthy, Adeline Vanderver, Jamie L. Fraser, and Jennifer Orthmann-Murphy: Glial Origins of Inherited White Matter Disorders. Additional Perspectives on Glia in Cold Spring Harb Perspect Biol. Beth Stevens, Kelly R. Monk, and Marc R. Freeman (eds.). in press 2024.

Rebecca L. Koch, Claudia Soler-Alfonso, Bridget T. Kiely, Akihiro Asai, Ariana L. Smith, Deeksha S. Bali, Peter B. Kang, Andrew P. Landstrom, H. Orhan Akman, T. Andrew Burrow, Jennifer L. Orthmann-Murphy, Deberah S. Goldman, Surekha Pendyal, Areeg H. El-Gharbawy, Stephanie L. Austin, Laura E. Case, Raphael Schiffmann, Michio Hirano, and Priya S. Kishnani: Diagnosis and management of glycogen storage disease type IV, including adult polyglucosan body disease: A clinical practice resource. Molecular Genetics and Metabolism March 2023.

Hannah Loo and Jennifer L Orthmann-Murphy: How do deep cortical microglia impair remyelination? Gordon Research Conference Poster - Glial Biology March 2023.

Joseph Gallegos, Hannah Loo, Thomas Malloy, Jennifer L Orthmann-Murphy: Does a toxic reactive astrocyte subtype influence oligodendrocyte recovery in the cortex? ACTRIMS Annual Meeting Poster 434 February 2023.

Al-alya Alsabah, Zehra Isik Hasiloglu, Rami Massie, Bernard Brais, *Jennifer Orthmann Murphy, *Roberta La Piana: Prevalence of Peripheral Nervous System Involvement in Adult Leukodystrophies. AAN annual meeting 2023.

Alexandra Kornbluh and Jennifer L Orthmann-Murphy: A Practical Approach to Longitudinal Neurological Care of Adults With X-linked Adrenoleukodystrophy and Adrenomyeloneuropathy (X-ALD/AMN). American Academy of Neurology Annual Meeting Poster P17-4.009 May 2022.

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Last updated: 07/12/2024
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