John A. Wolf, Ph.D.

faculty photo
Research Associate Professor of Neurosurgery
Department: Neurosurgery
Graduate Group Affiliations

Contact information
Rm.172A Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104
Office: 215-746-4680
Lab: 215-898-5102
B.A. (Biology)
University of Pennsylvania, 1994.
Ph.D. (Neuroscience)
University of Pennsylvania, 2006.
M.S.Ed (School and Mental Health Counseling)
University of Pennsylvania, 2011.
Permanent link

Description of Research Expertise

My laboratory focuses on the effects of traumatic brain injury on the limbic system, including the hippocampus, PFC, and amygdala. We are particularly interested in the changes in coding in these structures, as well as the interactions between them, in both cognition and emotional processing. We are developing new targets of neuromodulation for these regions and their connections as well.

Selected Publications

Alexandra V. Ulyanova, Carlo Cottone, Christopher D. Adam, Nikhil Maheshwari, Michael R. Grovola, Oceane E. Fruchet, Jami Alamar, Paul F. Koch, Victoria E. Johnson, D. Kacy Cullen, John A. Wolf: Hippocampal Interneuronal Dysfunction and Hyperexcitability in a Porcine Model of Concussion. Communications Biology October 2023.

James P. Harris, Constance J. Mietus, Kevin D. Browne, Kathryn L. Wofford, Carolyn E. Keating, Daniel P. Brown, Brian N. Johnson, John A. Wolf, Douglas H. Smith, Akiva S. Cohen, John E. Duda, D. Kacy Cullen: Neuronal somatic plasmalemmal permeability and dendritic beading caused by head rotational traumatic brain injury in pigs–An exploratory study. Frontiers Cellular Neuroscience 17, July 2023.

Eberwine J, Kim J, Anafi RC, Brem S, Bucan M, Fisher SA, Grady MS, Herr AE, Issadore D, Jeong H, Kim H, Lee D, Rubakhin S, Sul JY, Sweedler JV, Wolf JA, Zaret KS, Zou J.: Subcellular omics: a new frontier pushing the limits of resolution, complexity and throughput. Nat Methods March 2023.

Jgamadze D, Lim JT, Zhang Z, Harary PM, Germi J, Mensah-Brown K, Adam CD, Mirzakhalili E, Singh S, Gu JB, Blue R, Dedhia M, Fu M, Jacob F, Qian X, Gagnon K, Sergison M, Fruchet O, Rahaman I, Wang H, Xu F, Xiao R, Contreras D, Wolf JA, Song H, Ming GL, Chen HI.: Structural and functional integration of human forebrain organoids with the injured adult rat visual system. Cell Stem Cell 30: 137-152, Feb 2023.

Smith DH, Burrell JC, Browne KD, Katiyar KS, Ezra MI, Dutton JL, Morand JP, Struzyna LA, Laimo FA, Chen HI, Wolf JA, Kaplan HM, Rosen JM, Ledebur HC, Zager EL, Ali ZS, Cullen DK.: Tissue-engineered grafts exploit axon-facilitated axon regeneration and pathway protection to enable recovery after 5-cm nerve defects in pigs. Sci Adv 8: eabm3291, Nov 2022.

Galanopoulou, Aristea S., Löscher, Wolfgang, Lubbers, Laura, O’Brien, Terence J., Staley, Kevin, Vezzani, Annamaria, D’Ambrosio, Raimondo, White, H. Steve, Sontheimer, Harald, Wolf, John A., Twyman, Roy, Whittemore, Vicky, Wilcox, Karen S., Klein, Brian: Antiepileptogenesis and disease modification: Progress, challenges, and the path forward—Report of the Preclinical Working Group of the 2018 NINDS-sponsored antiepileptogenesis and disease modification workshop. Epilepsia Open 6(2): 276-296, Jun 2021.

Grovola, M. R., Paleologos, N., Brown, D. P., Tran, N., Wofford, K. L., Harris, J. P., Browne, K. D., Shewokis, P. A., Wolf, J. A., Cullen, D. K., Duda, J. E.: Diverse changes in microglia morphology and axonal pathology during the course of 1 year after mild traumatic brain injury in pigs. Brain Pathol Page: e12953, May 2021 Notes: [Epub Ahead of Print]

Nicolette Driscoll, Brian Erickson, Brendan B Murphy, Andrew G Richardson, Gregory Robbins, Nicholas V Apollo, Tyler Mathis, Kanit Hantanasirisakul, Puneet Bagga, Sarah E Gullbrand, Matthew Sergison, Ravinder Reddy, John A Wolf, H Isaac Chen, Timothy H Lucas, Timothy Dillingham, Kathryn A Davis, Yury Gogotsi, John D Medaglia, Flavia Vitale: MXtrodes: MXene-infused bioelectronic interfaces for multiscale electrophysiology and stimulation Science Translational Medicine Mar 2021 Notes: [Epub Ahead of Print]

Adewole, D. O., Struzyna, L. A., Burrell, J. C., Harris, J. P., Nemes, A. D., Petrov, D., Kraft, R. H., Chen, H. I., Serruya, M. D., Wolf, J. A., Cullen, D. K.: Development of optically controlled "living electrodes" with long-projecting axon tracts for a synaptic brain-machine interface. Sci Adv 7(4), 2021.

Burrell, J. C., Browne, K. D., Dutton, J. L., Laimo, F. A., Das, S., Brown, D. P., Roberts, S., Petrov, D., Ali, Z., Ledebur, H. C., Rosen, J. M., Kaplan, H. M., Wolf, J. A., Smith, D. H., Chen, H. I., Cullen, D. K.: A Porcine Model of Peripheral Nerve Injury Enabling Ultra-Long Regenerative Distances: Surgical Approach, Recovery Kinetics, and Clinical Relevance. Neurosurgery 87(4): 833-846, Sep 2020.

back to top
Last updated: 10/25/2023
The Trustees of the University of Pennsylvania