Toshinori Hoshi, PhD

faculty photo
Professor of Physiology
Department: Physiology
Graduate Group Affiliations

Contact information
605 CRB
415 Curie Blvd
Department of Physiology
Philadelphia, PA 19104
Office: 215-573-7305
B.A. (Psychology)
University of New Hampshire, 1981.
Ph.D. (Physiology)
Yale University, 1985.
Permanent link

Description of Research Expertise

Ion channel modulation such as that of calcium-dependent potassium channels by heme, heme breakdown products such as CO, and lipid messengers including PIP2 and omega-3 fatty acids and of TMEM16A anion channels by small molecules produced by gut microbes.

neuronal excitability, ion channel gating, oxidation, methionine, aging, blood, heme, CO, brain hemorrhage, lipids, PIP2, omega-3 fatty acids, fish oil, BK channel, Slo1, KCNMA1, KCNMB, KCa1.1, LRRC, potassium channels, voltage sensor, Shaker channels, EAG, Kv, KCNH

Electrophysiology (patch clamp, voltage-clamp, extracellular recording, optical recording); molecular biology; tissue culture; vascular smooth muscle physiology; gut physiology; microbiota; physiology and behavior.

We study modulation of ion channels such as large-conductance calcium- and voltage-gated potassium channels and TMEM16A anion channels by different signaling molecules. The modulators/modulatory processes being examined include: oxidation/reduction of amino acids, carbon monoxide, heme, bilirubin oxidation end products, PIP2 and omega-3 fatty acids. Our recent focus includes the small molecules produced gut microbes.

Selected Publications

Ojha, N. K., Leipold, E., Schonherr, R., Hoshi, T., Heinemann, S. H.: Non-photonic sensing of membrane-delimited reactive species with a Na+ channel protein containing selenocysteine Sci Rep 7: 46003, 2017.

Gessner, G., Sahoo, N., Swain, S. M., Hirth, G., Schonherr, R., Mede, R., Westerhausen, M., Brewitz, H. H., Heimer, P., Imhof, D., Hoshi, T., Heinemann, S. H.: CO-independent modification of K+ channels by tricarbonyldichlororuthenium(II) dimer (CORM-2). Eur J Pharmacol 815: 33-41, 2017.

Tian, Y., Aursnes, M., Hansen, T. V., Tungen, J. E., Galpin, J. D., Leisle, L., Ahern, C. A., Xu, R., Heinemann, S. H., Hoshi, T.: Atomic determinants of BK channel activation by polyunsaturated fatty acids. Proc Natl Acad Sci U S A 113(48): 13905-13910, 2016.

Han, B., He, K., Cai, C., Tang, Y., Yang, L., Heinemann, S. H., Hoshi, T., Hou, S.: Human EAG channels are directly modulated by PIP2 as revealed by electrophysiological and optical interference investigations. Sci Rep 6: 23417, 2016.

Schink, M., Leipold, E., Schirmeyer, J., Schonherr, R., Hoshi, T., Heinemann, S. H.: Reactive species modify NaV1.8 channels and affect action potentials in murine dorsal root ganglion neurons. Pflügers Arch 468(1): 99-110, 2016.

Hoshi, T., Heinemann, S. H.: Modulation of BK channels by small endogenous molecules and pharmaceutical channel openers. Int Rev Neurobiol. C. Contet (eds.). 128: 193-237, 2016.

Hoshi, T., Armstrong, C. M.: The Cole-Moore Effect: Still Unexplained? Biophys J 109(7): 1312-6, 2015.

Golder, F. J., Dax, S., Baby, S. M., Gruber, R., Hoshi, T., Ideo, C., Kennedy, A., Peng, S., Puskovic, V., Ritchie, D., Woodward, R., Wardle, R. L., Van Scott, M. R., Mannion, J. C., MacIntyre, D. E.: Identification and characterization of GAL-021 as a novel breathing control modulator. Anesthesiology 123(5): 1093-104, 2015.

Tian, Y., Ullrich, F., Xu, R., Heinemann, S. H., Hou, S., Hoshi, T.: Two distinct effects of PIP2 underlies auxiliary subunit-dependent modulation of Slo1 BK channels. J Gen Physiol 145(4): 331-43, 2015.

Horrigan, F. T., Hoshi, T.: Models of ion channel gating. Handbook of ion channels. Zheng, J. Trudeau, M. C. (eds.). CRC Press, Page: 81-99, 2015.

back to top
Last updated: 08/22/2018
The Trustees of the University of Pennsylvania