Faculty

Allan I. Pack, M.B.Ch.B., Ph.D., FRCP

John Miclot Professor

Department: Medicine

Graduate Group Affiliations

Contact information

Translational Research Laboratories
125 South 31st Street, Suite 2100
Philadelphia, PA 19104-3403

Office: 215-746-4806
Fax: 215-746-4814

Email:
PACK@PENNMEDICINE.UPENN.EDU

Publications

Search PubMed for articles

Education:
M.B.Ch.B
University of Glasgow, Scotland, 1967.
Ph.D. (Mathematical models of lung function)
University of Glasgow, Scotland, 1976.

Links
Search PubMed for articles
Primary Work Website
Neuroscience graduate group faculty webpage.

Permanent link

SOM Home » BGS Home » NGG Home » Faculty

Description of Research Expertise

Dr. Pack is pursuing research on genetics/genomics of sleep and its disorders. His laboratory is conducting studies in Drosophila and mice and translating these findings to humans. A particular focus of Dr. Pack’s work is to evaluate the genetic determinants of sleep homeostasis. Studies are ongoing to evaluate molecular mechanisms of sleepiness and sleep promotion using both hypothesis-driven and discovery science. The latter involves analysis of the changes in the transcription with sleep/wake and sleep deprivation in identified neuronal populations. Techniques being used include behavioral/sleep studies in Drosophila and mice, RT-PCR, Western analysis of protein, expression profiling, laser microcapture dissection, RNA seq and immunohistochemistry. Dr. Pack is committed to research training and directs three training grants from the National Institutes of Health.

Selected Publications

Goldschmied, J.R., Kuna, S.T., Maislin, G., Tanayapong, P., Pack, A.I., Younes, M.: The sleep homeostatic response to sleep deprivation in humans is heritable. Sleep 46(3): zsac314, Mar 2023.

Pak, V.M., Maislin, D.G., Keenan, B.T., Townsend, R., Benediktsdottir, B., Guo, X., Pack, A.I., Gislason, T., and Kuna, S.T.: Obesity does not modify the effect of 4 months of CPAP on leptin or adiponectin. ERJ Open Res. 9(2), Mar 2023.

Thorarinsdottir, E.H., Gislason, T., Pack, A.I., Kuna, S.T., Penzel, T., Han, F., Li, Q.Y., cistulli, P.A., Magalang, U.J., McArdle, N., Singh, B., and Keenan, B.T.: Evaluation of excessive daytime sleepiness in obstructive sleep apnea across international sleep centers. Sleep Page: zsac271, Nov 16 2022.

Matura, L.A., Fargo, J.D., Boyle, K., Fritz, J.S., Smith, K.A., Mazurek, J.A., Archer-Chicko, C.L., Palevsky, H.I., Pack, A.I., Somers, M.S., and Kawut, S.M.: Symptom phenotypes in pulmonary arterial hypertension: The PAH “symptome” Pulmonary Circulation 12(3): e12135, Jul 1 2022.

Thorarinsdottir, E.H., Janson, C., Aspelund, T., Benediktsdottir, B., Juliusson, S., Gislason, T., Kuna, S.T., Pack, A.I., and Keenan, B.T.: Different components of excessive daytime sleepiness and the change with positive airway pressure in obstructive sleep apnea patients – results from the Icelandic Sleep Apnea Cohort (ISAC). Journal of Sleep Research 31(3): e13528, Jun 2022.

Reynor, A., McArdle, N., Shenoy, B., Dhaliwal, S.S., Rea, S.C., Walsh, J., Eastwood, P.R., Maddison, K., Hillman, D.R., Ling, I., Keenan, B.T., Maislin, G., Magalang, U., Pack, A.I., Mazzotti, D.R., Lee, C.H., and Singh, B.: Continuous positive airway pressure and adverse cardiovascular events in obstructive sleep apnea: Are participants of randomized trials representative of sleep clinic patients? Sleep 45(4): zsab264, Apr 2022.

Holfinger, S.J., Lyons, M.M., Keenen, B.T., Mazzotti, D.R., Mindel, J., Maislin, G., Cistulli, P.A., Sutherland, K., McArdle, N., Singh, B., Chen, N.H., Gislason, T., Penzel, T., Han, F., Li, Q.Y., Schwab, R., Pack, A.I., and Magalang, U.J.: Diagnostic performance of machine learning-derived OSA prediction tools in large clinical and community-based samples. Chest 161(3): 807-817, Mar 2022.

Keenan, B.T., Magalang, U.J., Mazzotti, D.R., McArdle, N., Gislason, T., Singh, B., Maislin, G., and Pack, A.I.: Obstructive sleep apnea symptom subtypes and cardiovascular risk: conflicting evidence to an important question. American Journal of Respiratory and Critical Care Medicine 205(6): 729-730, Mar 2022.

Geuther, B., Chen, M., Galante, R.J., Han, O., Lian, J., George, J., Pack, A.I., and Kumar, V.: High-throughput visual assessment of sleep stages in mice using machine learning. Sleep 45(2): zsab260, Feb 2022.

Mazzotti, D.R., Keenan, B.T., Thorarinsdottir, E.H., Gislason, T., Pack, A.I., and Sleep Apnea Global Interdisciplinary Consortium: Is the Epworth Sleepiness Scale sufficient to identify the excessively sleepy subtype of OSA? Chest 161(2): 557-561, Feb 2022.