Charles H Vite, DVM, PhD, ACVIM (Neurology)

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Graduate Group Affiliations

Contact information
Section of Neurology & Neurosurgery
Department of Clinical Sciences and Advanced Medicine
School of Veterinary Medicine
University of Pennsylvania
3900 Delancey Street
Philadelphia, PA 19104-6010
Office: 215-898-9473
Fax: 215-898-9937
Cornell University, 1986.
Purdue University, 1990.
University of Pennsylvania, 2003.
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Description of Research Expertise

The focus of my lab is to improve the characterization and treatment of neurological diseases by studying naturally-occurring feline and canine models of human diseases. Our lab develops and identifies ante mortem biochemical and nuclear magnetic resonance markers of disease severity and progression and uses these markers to evaluate the efficacy of gene therapy, cell-based therapy, and pharmacotherapy to treat disease.
We currently maintain breeding colonies that produce cats affected with Niemann-Pick type C disease and alpha-mannosidosis, and dogs affected with globoid cell leukodystrophy and mucopolysaccharidoses. We also maintain dogs with naturally occurring epilepsy for which we are evaluating neurophysiologically-based response pharmacotherapy using intracranially EEG. The goal of this work is to develop methods to predict seizure occurrence and to prevent them. We will implant devices and maintain epileptic dogs proposed for use in this study.

Selected Publications

Swain, G P. Prociuk, M. Bagel, J H. O'Donnell, P. Berger, K. Drobatz, K. Gurda, B L. Haskins, M E. Sands, M S. Vite, C H.: Adeno-associated virus serotypes 9 and rh10 mediate strong neuronal transduction of the dog brain. Gene Therapy 21(1): 28-36, Jan 2014.

Howbert, J Jeffry. Patterson, Edward E. Stead, S Matt. Brinkmann, Ben. Vasoli, Vincent. Crepeau, Daniel. Vite, Charles H. Sturges, Beverly. Ruedebusch, Vanessa. Mavoori, Jaideep. Leyde, Kent. Sheffield, W Douglas. Litt, Brian. Worrell, Gregory A.: Forecasting seizures in dogs with naturally occurring epilepsy. PLoS ONE [Electronic Resource] 9(1): e81920, 2014.

Coles, Lisa D. Patterson, Edward E. Sheffield, W Douglas. Mavoori, Jaideep. Higgins, Jason. Michael, Bland. Leyde, Kent. Cloyd, James C. Litt, Brian. Vite, Charles. Worrell, Gregory A.: Feasibility study of a caregiver seizure alert system in canine epilepsy. Epilepsy Research 106(3): 456-60, Oct 2013.

Fan, Martin. Sidhu, Rohini. Fujiwara, Hideji. Tortelli, Brett. Zhang, Jessie. Davidson, Cristin. Walkley, Steven U. Bagel, Jessica H. Vite, Charles. Yanjanin, Nicole M. Porter, Forbes D. Schaffer, Jean E. Ory, Daniel S.: Identification of Niemann-Pick C1 disease biomarkers through sphingolipid profiling. Journal of Lipid Research 54(10): 2800-14, Oct 2013.

Bagel, Jessica H. Sikora, Tracey U. Prociuk, Maria. Pesayco, Jill P. Mizisin, Andrew P. Shelton, G Diane. Vite, Charles H.: Electrodiagnostic testing and histopathologic changes confirm peripheral nervous system myelin abnormalities in the feline model of niemann-pick disease type C. Journal of Neuropathology & Experimental Neurology 72(3): 256-62, Mar 2013.

Roszell, Blair R. Tao, Jian-Qin. Yu, Kevin J. Gao, Ling. Huang, Shaohui. Ning, Yue. Feinstein, Sheldon I. Vite, Charles H. Bates, Sandra R.: Pulmonary abnormalities in animal models due to Niemann-Pick type C1 (NPC1) or C2 (NPC2) disease. PLoS ONE [Electronic Resource] 8(7): e67084, 2013.

Porter, Forbes D. Scherrer, David E. Lanier, Michael H. Langmade, S Joshua. Molugu, Vasumathi. Gale, Sarah E. Olzeski, Dana. Sidhu, Rohini. Dietzen, Dennis J. Fu, Rao. Wassif, Christopher A. Yanjanin, Nicole M. Marso, Steven P. House, John. Vite, Charles. Schaffer, Jean E. Ory, Daniel S.: Cholesterol oxidation products are sensitive and specific blood-based biomarkers for Niemann-Pick C1 disease. Science Translational Medicine 2(56): 56ra81, Nov 3 2010.

Ward, Sarah. O'Donnell, Patricia. Fernandez, Steven. Vite, Charles H.: 2-hydroxypropyl-beta-cyclodextrin raises hearing threshold in normal cats and in cats with Niemann-Pick type C disease. Pediatric Research 68(1): 52-6, Jul 2010.

Malik, Saafan Z. Lewis, Melissa. Isaacs, Alison. Haskins, Mark. Van Winkle, Thomas. Vite, Charles H. Watson, Deborah J.: Identification of the rostral migratory stream in the canine and feline brain. PLoS ONE [Electronic Resource] 7(5): e36016, 2012.

Stein, Veronika M. Crooks, Alexandra. Ding, Wenge. Prociuk, Maria. O'Donnell, Patricia. Bryan, Caroline. Sikora, Tracey. Dingemanse, Jasper. Vanier, Marie T. Walkley, Steven U. Vite, Charles H.: Miglustat improves purkinje cell survival and alters microglial phenotype in feline Niemann-Pick disease type C. Journal of Neuropathology & Experimental Neurology 71(5): 434-48, May 2012.

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Last updated: 06/10/2020
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