Faculty

32 1a 2a

61 16

Charles H Vite, DVM, PhD, ACVIM (Neurology)

7 4 1 23

1f Graduate Group Affiliations 8

Neuroscience

46 Contact information
51

Section of Neurology & Neurosurgery
3e Department of Clinical Sciences and Advanced Medicine
25 School of Veterinary Medicine
22 University of Pennsylvania
3c 3900 Delancey Street
Philadelphia, PA 19104-6010

2e Office: 215-898-9473
32 Fax: 215-898-9937
24

Email:
vite@vet.upenn.edu

4 3 3 3 2 4 b 1f

13 Education:
21 9 B.S. c
2b Cornell University, 1986.
21 8 DVM c
2a Purdue University, 1990.
21 8 PhD c
33 University of Pennsylvania, 2003.
c

3 27

Links
67 Gene therapy for NPC disease
59 National MPS Society
5b Fight NPC
d6 Information on the National Referral Center for Animal Models of Human Genetic Diseases b
8b International Society for Mannosidosis and Related Diseases
9c On-line textbook, Clinical Neurology in Small Animals - Localization, Diagnosis, and Treatment
66 Support of Accelerated Research for NPC
a1 Profile in Penn Vet Research newsletter
80 Ara Parseghian Medical Research Foundation
c

5 3 3 90 Permanent link
2 29

d1 SOM Home » BGS Home » NGG Home » Faculty a

1e 1d

Description of Research Expertise

1ba The focus of my lab is to improve the characterization and treatment of neurological diseases by studying naturally-occurring feline and canine models of human diseases. Our lab develops and identifies ante mortem biochemical and nuclear magnetic resonance markers of disease severity and progression and uses these markers to evaluate the efficacy of gene therapy, cell-based therapy, and pharmacotherapy to treat disease.
228 We currently maintain breeding colonies that produce cats affected with Niemann-Pick type C disease and alpha-mannosidosis, and dogs affected with globoid cell leukodystrophy and mucopolysaccharidoses. We also maintain dogs with naturally occurring epilepsy for which we are evaluating neurophysiologically-based response pharmacotherapy using intracranially EEG. The goal of this work is to develop methods to predict seizure occurrence and to prevent them. We will implant devices and maintain epileptic dogs proposed for use in this study.
e 29

Selected Publications

154 Swain, G P. Prociuk, M. Bagel, J H. O'Donnell, P. Berger, K. Drobatz, K. Gurda, B L. Haskins, M E. Sands, M S. Vite, C H.: Adeno-associated virus serotypes 9 and rh10 mediate strong neuronal transduction of the dog brain. Gene Therapy 21(1): 28-36, Jan 2014.

1c0 Howbert, J Jeffry. Patterson, Edward E. Stead, S Matt. Brinkmann, Ben. Vasoli, Vincent. Crepeau, Daniel. Vite, Charles H. Sturges, Beverly. Ruedebusch, Vanessa. Mavoori, Jaideep. Leyde, Kent. Sheffield, W Douglas. Litt, Brian. Worrell, Gregory A.: Forecasting seizures in dogs with naturally occurring epilepsy. PLoS ONE [Electronic Resource] 9(1): e81920, 2014.

182 Coles, Lisa D. Patterson, Edward E. Sheffield, W Douglas. Mavoori, Jaideep. Higgins, Jason. Michael, Bland. Leyde, Kent. Cloyd, James C. Litt, Brian. Vite, Charles. Worrell, Gregory A.: Feasibility study of a caregiver seizure alert system in canine epilepsy. Epilepsy Research 106(3): 456-60, Oct 2013.

1bb Fan, Martin. Sidhu, Rohini. Fujiwara, Hideji. Tortelli, Brett. Zhang, Jessie. Davidson, Cristin. Walkley, Steven U. Bagel, Jessica H. Vite, Charles. Yanjanin, Nicole M. Porter, Forbes D. Schaffer, Jean E. Ory, Daniel S.: Identification of Niemann-Pick C1 disease biomarkers through sphingolipid profiling. Journal of Lipid Research 54(10): 2800-14, Oct 2013.

1b7 Bagel, Jessica H. Sikora, Tracey U. Prociuk, Maria. Pesayco, Jill P. Mizisin, Andrew P. Shelton, G Diane. Vite, Charles H.: Electrodiagnostic testing and histopathologic changes confirm peripheral nervous system myelin abnormalities in the feline model of niemann-pick disease type C. Journal of Neuropathology & Experimental Neurology 72(3): 256-62, Mar 2013.

172 Roszell, Blair R. Tao, Jian-Qin. Yu, Kevin J. Gao, Ling. Huang, Shaohui. Ning, Yue. Feinstein, Sheldon I. Vite, Charles H. Bates, Sandra R.: Pulmonary abnormalities in animal models due to Niemann-Pick type C1 (NPC1) or C2 (NPC2) disease. PLoS ONE [Electronic Resource] 8(7): e67084, 2013.

222 Porter, Forbes D. Scherrer, David E. Lanier, Michael H. Langmade, S Joshua. Molugu, Vasumathi. Gale, Sarah E. Olzeski, Dana. Sidhu, Rohini. Dietzen, Dennis J. Fu, Rao. Wassif, Christopher A. Yanjanin, Nicole M. Marso, Steven P. House, John. Vite, Charles. Schaffer, Jean E. Ory, Daniel S.: Cholesterol oxidation products are sensitive and specific blood-based biomarkers for Niemann-Pick C1 disease. Science Translational Medicine 2(56): 56ra81, Nov 3 2010.

134 Ward, Sarah. O'Donnell, Patricia. Fernandez, Steven. Vite, Charles H.: 2-hydroxypropyl-beta-cyclodextrin raises hearing threshold in normal cats and in cats with Niemann-Pick type C disease. Pediatric Research 68(1): 52-6, Jul 2010.

149 Malik, Saafan Z. Lewis, Melissa. Isaacs, Alison. Haskins, Mark. Van Winkle, Thomas. Vite, Charles H. Watson, Deborah J.: Identification of the rostral migratory stream in the canine and feline brain. PLoS ONE [Electronic Resource] 7(5): e36016, 2012.

1d2 Stein, Veronika M. Crooks, Alexandra. Ding, Wenge. Prociuk, Maria. O'Donnell, Patricia. Bryan, Caroline. Sikora, Tracey. Dingemanse, Jasper. Vanier, Marie T. Walkley, Steven U. Vite, Charles H.: Miglustat improves purkinje cell survival and alters microglial phenotype in feline Niemann-Pick disease type C. Journal of Neuropathology & Experimental Neurology 71(5): 434-48, May 2012.

2c

7 1d

2c back to top
26 Last updated: 06/10/2020
34 The Trustees of the University of Pennsylvania c

1 49 2 2 1a 32 34