Faculty

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Kenneth S. Shindler, M.D., Ph.D.

F.M. Kirby Professor of Ophthalmology

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Department: Ophthalmology

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1f Graduate Group Affiliations 8

Neuroscience

46 Contact information
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Scheie Eye Institute
37 51 North 39th Street
Philadelphia, PA 19104

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18 Publications
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13 Education:
21 8 ScB 19 (Biochemistry) c
35 Brown University, Providence, 1991.
21 c MD, PhD 22 (Medicine/Neuroscience) c
39 Washington University, St. Louis, 1999.
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Links
115 Search PubMed for articles
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Description of Research Expertise

232 Dr. Shindler's research is examining potential mechanisms to provide neuroprotection of retinal ganglion cells in optic neuritis. Optic neuritis is an inflammatory disease of the optic nerve that often occurs as part of the neurodegenerative disease multiple sclerosis. Damage to nerve cells can lead to permanent vision loss in these patients. Dr. Shindler's studies are helping to identify new therapies to prevent nerve damage in this disease, and such therapies will also likely have benefits for other neurodegenerative diseases as well.
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17 Keywords
6e Neuro-ophthalmologic conditions, including optic neuropathies, papilledema, and binocular double vision
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Selected Publications

151 McDougald DS, Dine KE, Zezulin AU, Bennett J, Shindler KS: SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function in Experimental Optic Neuritis. Invest. Ophthalmol. Vis. Sci. 59: 1212-1220, Mar 2018.

129 Grinblat GA, Khan RS, Dine K, Wessel H, Brown L, Shindler KS: RGC Neuroprotection Following Optic Nerve Trauma Mediated By Intranasal Delivery of Amnion Cell Secretome. Invest. Ophthalmol. Vis. Sci. 59: 2470-2477, May 2018.

15e Khan RS, Dine K, Bauman B, Lorentsen M, Lin L, Brown H, Hanson LR, Svitak AL, Wessel H, Brown L, Shindler KS: Intranasal Delivery of A Novel Amnion Cell Secretome Prevents Neuronal Damage and Preserves Function In A Mouse Multiple Sclerosis Model. Sci. Rep. 7: 41768, Jan 2017.

56 Khan RS, Dine K, Das Sarma J, Shindler KS 7f : SIRT1 activating compounds reduce oxidative stress mediated neuronal loss in viral induced CNS demyelinating disease 45 Acta Neuropathol. Commun. 2(1): 3, Jan 2014.

108 Zuo L, Khan RS, Lee V, Dine K, Wu W, Shindler KS: SIRT1 promotes RGC survival and delays loss of function following optic nerve crush. Invest. Ophthalmol. Vis. Sci. 54(7): 5097-102, Jul 2013.

e6 Chen Y, Khan RS, Cwanger A, Song Y, Steenstra C, Bang S, Cheah JH, Dunaief J, Shindler KS, Snyder SH, Kim SF: Dexras1, a small GTPase, is required for glutamate-NMDA neurotoxicity 2 3e J. Neurosci. 33(8): 3582-7, Feb 2013.

102 Fonseca-Kelly Z, Nassrallah M, Uribe J, Khan RS, Dine K, Dutt M, Shindler KS: Resveratrol neuroprotection in a chronic mouse model of multiple sclerosis. Front. Neurol. 3: 84, May 2012.

154 Shindler KS, Chatterjee D, Biswas K, Goyal A, Dutt M, Nassrallah M, Khan RS, Das Sarma J: Macrophage-mediated optic neuritis induced by retrograde axonal transport of spike gene recombinant mouse hepatitis virus. J. Neuropathol. Exp. Neurol. 70(6): 470-80, June 2011.

109 Shindler KS, Ventura E, Dutt M, Elliott P, Fitzgerald DC, Rostami A: Oral resveratrol reduces neuronal damage in a model of multiple sclerosis. J. of Neuro-Ophthalmol. 30(4): 328-39, Dec 2010.

f1 Das Sarma J, Kenyon LC, Hingley ST, Shindler KS: Mechanisms of primary axonal damage in a viral model of multiple sclerosis J. Neurosci. 29(33): 10272-10280, Aug 2009.

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