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  • Judith B. Grinspan
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Faculty

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Judith B. Grinspan, Ph.D.

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Research Professor of Neurology
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Department: Neurology
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1f Graduate Group Affiliations 8 a
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46 Contact information
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Children’s Hospital of Philadelphia
37 516D Abramson Center
Philadelphia, PA 19104
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30 Office: (215) 590-2094
34 Fax: (215) 590-3709
34 Lab: (215) 590-5179
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Email: GRINSPAN@EMAIL.CHOP.EDU
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18 Publications
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13 Education:
21 9 A.B. 14 (Biology) c
28 Vassar College , 1974.
 21 9 M.S. 16 (Pathology) c
45 Hahnemann University (now Drexel University), 1977.
 21 a Ph.D. 14 (Biology) c
33 University of Pennsylvania, 1984.
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Links
99 Search PubMed for articles
 42 Neuroscience graduate group faculty webpage.
46 Cell and Molecular Biology graduate group faculty webpage.
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Description of Research Expertise

2b Research Interests
ae Our lab studies factors that control the maturation of oligodendrocytes, the myelinating cells of the central nervous system, from stem cells through to myelination.
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71 Key words: oligodendrocytes, myelin, growth factors, oxidative stress, neuroinflammation, MS, HIV.
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26 Description of Research
56e In the central nervous system, oligodendrocytes synthesize myelin as an extension of their plasma membranes. This myelin wraps axons and facilitates rapid and efficient conduction of nervous impulses as well as axonal nourishment and protection. Destruction of myelin through injury, such as birth injury leading to cerebral palsy, or disease, such as multiple sclerosis or HIV, causes loss of motor and cognitive function. Oligodendrocyte precursors and stem cells remain in the CNS following the pathology and are potentially capable of forming mature oligodendrocytes and then myelin. However, their maturation is severely limited. Reasons for this include processes such as oxidative stress and inflammation which signal to inhibitors present in the area that impede maturation. Our goal is to identify factors in the CNS that inhibit the development of mature oligodendrocytes both during development and disease. We have identified several key signaling factors that regulate developmental myelination and are increased during demyelinating disease. On-going areas of investigation in the lab include: 1) The role of white matter loss and demyelination in HIV-associated neurocognitive deficits. 2) Factors which limit myelination in perinatal white matter injury. 3) The role of lipid signaling in developmental myelination and remyelination following demyelinating disease.
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1d Lab personnel:
26 Micah Romer research assistant
27 Bassam Zidane, graduate student
25 Lindsay Roth, graduate student
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Selected Publications

16e Monnerie, H., Romer, M., Jensen, B., Millar, J., Jordan-Sciutto, K., Kim, S.F., Grinspan, J.B.: Reduced Sterol Regulatory Element-Binding Protein (SREBP) Processing through Site-1 Protease (S1P) Inhibition Alters Oligodendrocyte differentiation In Vitro. J. Neurochem. 140(1): 53-67, Jan 2017.

 ee Jensen, B.K., Monnerie, H., Mannell, M.V., Gannon, P.J., Espinoza-Akay, C., Erickson, M.A., Bruce-Keller, A.J., Gelman, B.B., Briand, L.A., R. Pierce, R.C., Jordan-Sciutto, K.L., Grinspan, J.B. 2 f3 : Altered Oligodendrocyte Maturation and Myelin Maintenance: The Role of Anti-Retrovirals in HIV-Associated Neurocognitive Disorders. Journal of Neuropathology Experimental Neurology 74(11): 1093-1118, Nov 2015.

 147 Veasey, S.C., Lear, J., Zhu, Y.,Grinspan, J. B., Hare, D.J., Wang, S., Bunch,D., Lim, D.C., Doble, P.A., Robinson, S.R.: Long-term Intermittent Hypoxia Elevates Cobalt Levels in the Brain and Injures White Matter in Adult Mice. Sleep 36: 1471-1481, 2013.

 159 Reid, M.V., Murray, K. A., Marsh, E.D., Golden, J. A., Simmons, R.A., Grinspan, J. B.: Delayed myelination in an intrauterine growth retardation model is mediated by oxidative stress upregulating BMP4. Journal of Neuropathology Experimental Neurology 71(7): 640-653, 2012.

 71 Feigenson, K., Reid, M., See, J., Crenshaw, E.B. III, Grinspan, J. B. 94 : Canonical Wnt signaling requires the BMP pathway to inhibit oligodendrocyte maturation. ASN NEURO 3: 147-158, 2011.

 fc French, H. M., Reid, M., Mamontov, P., Simmons, R. A., Grinspan, J. B.: Oxidative stress disrupts oligodendrocyte maturation. Journal of Neuroscience Research 87: 3076-3087, 2009.

 108 Feigenson, K., Reid, M., See, J., Crenshaw E.B. III, Grinspan, J. B.: Wnt signaling is sufficient to perturb oligodendrocyte maturation. Molecular and Cellular Neuroscience 42: 255-265, 2009.

 150 Ara, J., See, J., Mamontov, P., Hahn, A., Bannerman, P. Pleasure, D., Grinspan, J.B.: Bone morphogenetic proteins 4, 6, and7 are upregulated in mouse spinal cord during experimental autoimmune encephalomyelitis. Journal of Neuroscience Research 86: 125-135, 2008.

 108 See, J., Mamontov, P., Ahn K., Wine-Lee, L., Crenshaw III, E.B., Grinspan, J. B.: BMP mutant mice exhibit glial cell maturation defects. Molecular and Cellular Neuroscience 35: 171-182, 2007.

 11a See, J., Zhang, X., Eraydin, N. Mun, S.B., Mamontov, P., Golden, J. Grinspan, J.B.: Oligodendrocyte maturation is inhibited by bone morphogenetic protein. Molecular and Cellular Neuroscience 26: 481-492, 2004.

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