Faculty

John B. Hogenesch, Ph.D.

Adjunct Professor of Pharmacology

Department: Pharmacology

Contact information

T5.478
240 Albert Sabin Way
Cincinnati, OH 45229

Office: 4848424232

Email:
hogenesc@mail.med.upenn.edu

Education:
B.A. (History)
University of Southern California, 1989.
B.S. (Biology)
University of Southern California, 1991.
Ph.D. (Neuroscience)
Northwestern University, 1999.

Links
Hogenesch Lab Homepage

Permanent link

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Description of Research Expertise

Our laboratory researches the mammalian circadian clock, which is responsible for regulating daily rhythms of physiology and behavior in mammals. We use systems biology approaches, leveraging genomic and computational tools to identify new clock genes and understand how the clock keeps time. These findings inform the development of new methods and techniques that can be applied to many other areas of biology. Additionally, we collaborate with clinicians to translate our research into practical applications for human health and disease. Overall, our goal is to gain a comprehensive understanding of the circadian clock and its impact on physiology and behavior, and to use this knowledge to improve human health and wellbeing.

Selected Publications

Wang YM, Taggart CB, Huber JF, Davies SM, Smith DF, Hogenesch JB, Dandoy CE.: Daytime-restricted parenteral feeding is associated with earlier oral intake in children following stem cell transplant. J Clin Invest 133: e167275, Feb 2023.

Lee YY, Endale M, Wu G, Ruben MD, Francey LJ, Morris AR, Choo NY, Anafi RC, Smith DF, Liu AC, Hogenesch JB.: Integration of genome-scale data identifies candidate sleep regulators. Sleep 46: zsac279, Feb 2023.

Swanson GR, Biglin M, Raff H, Chouhan V, Jochum S, Shaikh M, Francey L, Bishehsari F, Hogenesch J, Keshavarzian A.: Impact of Chronotherapy on 6-Mercaptopurine Metabolites in Inflammatory Bowel Disease: A Pilot Crossover Trial. Clin Transl Gastroenterol 14: e00549, Feb 2023.

Rosselot AE, Park M, Kim M, Matsu-Ura T, Wu G, Flores DE, Subramanian KR, Lee S, Sundaram N, Broda TR, McCauley HA, Hawkins JA, Chetal K, Salomonis N, Shroyer NF, Helmrath MA, Wells JM, Hogenesch JB, Moore SR, Hong CI.: Ontogeny and function of the circadian clock in intestinal organoids. EMBO J 41: e106973, Dec 2022.

Petito GT, Housekeeper J, Buroker J, Scholle C, Ervin B, Frink C, Greiner HM, Skoch J, Mangano FT, Dye TJ, Hogenesch JB, Glauser TA, Holland KD, Arya R.: Diurnal rhythms of spontaneous intracranial high-frequency oscillations. Seizure Dec 2022.

Lee YY, Cal-Kayitmazbatir S, Francey LJ, Bahiru MS, Hayer KE, Wu G, Zeller MJ, Roberts R, Speers J, Koshalek J, Berres ME, Bittman EL, Hogenesch JB.: duper is a null mutation of Cryptochrome 1 in Syrian hamsters. Proc Natl Acad Sci U S A 119: e2123560119, May 2022.

Zhang T, Du X, Gu Y, Dong Y, Zhang W, Yuan Z, Huang X, Zou C, Zhou Y, Liu Z, Tao H, Yang L, Wu G, Hogenesch JB, Zhou CJ, Zhou F, Xu Y.: Analysis of Diurnal Variations in Heart Rate: Potential Applications for Chronobiology and Cardiovascular Medicine. Front Physiol 13: 835198, Mar 2022.

Shen Y, Endale M, Wang W, Morris AR, Francey LJ, Harold RL, Hammers DW, Huo Z, Partch CL, Hogenesch JB, Wu ZH, Liu AC.: NF-κB modifies the mammalian circadian clock through interaction with the core clock protein BMAL1. PLoS Genet 17: e1009933, Nov 2021.

Wu G, Francey LJ, Ruben MD, Hogenesch JB.: Normalized coefficient of variation (nCV): a method to evaluate circadian clock robustness in population scale data. Bioinformatics 37: 4581-3, Nov 2021.

Lahens NF, Brooks TG, Sarantopoulou D, Nayak S, Lawrence C, Mrčela A, Srinivasan A, Schug J, Hogenesch JB, Barash Y, Grant GR.: CAMPAREE: a robust and configurable RNA expression simulator. BMC Genomics 22: 692, Sep 2021.