John B. Hogenesch, Ph.D.

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Adjunct Professor of Pharmacology
Department: Pharmacology

Contact information
240 Albert Sabin Way
Cincinnati, OH 45229
Office: 4848424232
B.A. (History)
University of Southern California, 1989.
B.S. (Biology)
University of Southern California, 1991.
Ph.D. (Neuroscience)
Northwestern University, 1999.
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Description of Research Expertise

Our laboratory studies the mammalian circadian clock using genomic and computational tools. We use these tools to discover new clock genes, learn how the clock keeps time, and how it coordinates rhythms in physiology and behavior. This clock research drives development of genomic and computational methods that we apply to other areas of biology. Finally, we recognize biological complexity and conduct this research at the network, rather than single gene, level.

Selected Publications

Rosselot AE, Park M, Kim M, Matsu-Ura T, Wu G, Flores DE, Subramanian KR, Lee S, Sundaram N, Broda TR, McCauley HA, Hawkins JA, Chetal K, Salomonis N, Shroyer NF, Helmrath MA, Wells JM, Hogenesch JB, Moore SR, Hong CI.: Ontogeny and function of the circadian clock in intestinal organoids. EMBO J 41: e106973, Dec 2022.

Lee YY, Cal-Kayitmazbatir S, Francey LJ, Bahiru MS, Hayer KE, Wu G, Zeller MJ, Roberts R, Speers J, Koshalek J, Berres ME, Bittman EL, Hogenesch JB.: duper is a null mutation of Cryptochrome 1 in Syrian hamsters. Proc Natl Acad Sci U S A 119: e2123560119, May 2022.

Zhang T, Du X, Gu Y, Dong Y, Zhang W, Yuan Z, Huang X, Zou C, Zhou Y, Liu Z, Tao H, Yang L, Wu G, Hogenesch JB, Zhou CJ, Zhou F, Xu Y.: Analysis of Diurnal Variations in Heart Rate: Potential Applications for Chronobiology and Cardiovascular Medicine. Front Physiol 13: 835198, Mar 2022.

Shen Y, Endale M, Wang W, Morris AR, Francey LJ, Harold RL, Hammers DW, Huo Z, Partch CL, Hogenesch JB, Wu ZH, Liu AC.: NF-κB modifies the mammalian circadian clock through interaction with the core clock protein BMAL1. PLoS Genet 17: e1009933, Nov 2021.

Wu G, Francey LJ, Ruben MD, Hogenesch JB.: Normalized coefficient of variation (nCV): a method to evaluate circadian clock robustness in population scale data. Bioinformatics 37: 4581-3, Nov 2021.

Lahens NF, Brooks TG, Sarantopoulou D, Nayak S, Lawrence C, Mrčela A, Srinivasan A, Schug J, Hogenesch JB, Barash Y, Grant GR.: CAMPAREE: a robust and configurable RNA expression simulator. BMC Genomics 22: 692, Sep 2021.

Stokes K, Nunes M, Trombley C, Flôres DEFL, Wu G, Taleb Z, Alkhateeb A, Banskota S, Harris C, Love OP, Khan WI, Rueda L, Hogenesch JB, Karpowicz P.: The Circadian Clock Gene, Bmal1, Regulates Intestinal Stem Cell Signaling and Represses Tumor Initiation. Cell Mol Gastroenterol Hepatol Sep 2021.

Turgeon R, Althouse A, Cohen JB, Enache B, Hogenesch JB, Johansen M, Mehta R, Meyerowitz-Katz G, Ziaeian B, Hiremath S.: Response to Lowering Nighttime Blood Pressure with Bedtime Dosing of Antihypertensive Medications: Controversies in Hypertension - Pro Side of the Argument. Hypertension Sep 2021.

Turgeon RD, Althouse AD, Cohen JB, Enache B, Hogenesch JB, Johansen ME, Mehta R, Meyerowitz-Katz G, Ziaeian B, Hiremath S.: Lowering Nighttime Blood Pressure With Bedtime Dosing of Antihypertensive Medications: Controversies in Hypertension - Con Side of the Argument. Hypertension Sep 2021.

Wu G, Lee YY, Gulla EM, Potter A, Kitzmiller J, Ruben MD, Salomonis N, Whitsett JA, Francey LJ, Hogenesch JB, Smith DF.: Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary disease. Elife 10: e63003, Feb 2021.

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Last updated: 08/29/2022
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