John B. Hogenesch, Ph.D.

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Adjunct Professor of Pharmacology
Department: Systems Pharmacology and Translational Therapeutics

Contact information
240 Albert Sabin Way
Cincinnati, OH 45229
Office: 4848424232
B.A. (History)
University of Southern California, 1989.
B.S. (Biology)
University of Southern California, 1991.
Ph.D. (Neuroscience)
Northwestern University, 1999.
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Description of Research Expertise

Our laboratory researches the mammalian circadian clock, which is responsible for regulating daily rhythms of physiology and behavior in mammals. We use systems biology approaches, leveraging genomic and computational tools to identify new clock genes and understand how the clock keeps time. These findings inform the development of new methods and techniques that can be applied to many other areas of biology. Additionally, we collaborate with clinicians to translate our research into practical applications for human health and disease. Overall, our goal is to gain a comprehensive understanding of the circadian clock and its impact on physiology and behavior, and to use this knowledge to improve human health and wellbeing.

Selected Publications

Schwartz PB, Nukaya M, Berres ME, Rubinstein CD, Wu G, Hogenesch JB, Bradfield CA, Ronnekleiv-Kelly SM.: The circadian clock is disrupted in pancreatic cancer. PLoS Genet 19: e1010770, Jun 2023.

Koritala BSC, Lee YY, Gaspar LS, Bhadri SS, Su W, Wu G, Francey LJ, Ruben MD, Gong MC, Hogenesch JB, Smith DF.: Obstructive sleep apnea in a mouse model is associated with tissue-specific transcriptomic changes in circadian rhythmicity and mean 24-hour gene expression. PLoS Biol 21: e3002139, May 2023.

Cal-Kayitmazbatir S, Francey LJ, Lee Y, Liu AC, Hogenesch JB.: PSMD11 modulates circadian clock function through PER and CRY nuclear translocation. PLoS One 18: e0283463, Mar 2023.

Wang YM, Taggart CB, Huber JF, Davies SM, Smith DF, Hogenesch JB, Dandoy CE.: Daytime-restricted parenteral feeding is associated with earlier oral intake in children following stem cell transplant. J Clin Invest 133: e167275, Feb 2023.

Lee YY, Endale M, Wu G, Ruben MD, Francey LJ, Morris AR, Choo NY, Anafi RC, Smith DF, Liu AC, Hogenesch JB.: Integration of genome-scale data identifies candidate sleep regulators. Sleep 46: zsac279, Feb 2023.

Swanson GR, Biglin M, Raff H, Chouhan V, Jochum S, Shaikh M, Francey L, Bishehsari F, Hogenesch J, Keshavarzian A.: Impact of Chronotherapy on 6-Mercaptopurine Metabolites in Inflammatory Bowel Disease: A Pilot Crossover Trial. Clin Transl Gastroenterol 14: e00549, Feb 2023.

Rosselot AE, Park M, Kim M, Matsu-Ura T, Wu G, Flores DE, Subramanian KR, Lee S, Sundaram N, Broda TR, McCauley HA, Hawkins JA, Chetal K, Salomonis N, Shroyer NF, Helmrath MA, Wells JM, Hogenesch JB, Moore SR, Hong CI.: Ontogeny and function of the circadian clock in intestinal organoids. EMBO J 41: e106973, Dec 2022.

Petito GT, Housekeeper J, Buroker J, Scholle C, Ervin B, Frink C, Greiner HM, Skoch J, Mangano FT, Dye TJ, Hogenesch JB, Glauser TA, Holland KD, Arya R.: Diurnal rhythms of spontaneous intracranial high-frequency oscillations. Seizure Dec 2022.

Wu G, Ruben MD, Francey LJ, Lee YY, Anafi RC, Hogenesch JB.: An in silico genome-wide screen for circadian clock strength in human samples. Bioinformatics 38: 5375-5382, Dec 2022.

Lee YY, Cal-Kayitmazbatir S, Francey LJ, Bahiru MS, Hayer KE, Wu G, Zeller MJ, Roberts R, Speers J, Koshalek J, Berres ME, Bittman EL, Hogenesch JB.: duper is a null mutation of Cryptochrome 1 in Syrian hamsters. Proc Natl Acad Sci U S A 119: e2123560119, May 2022.

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Last updated: 03/01/2024
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