Faculty

Ethan M. Goldberg, M.D., Ph.D.

faculty photo
Assistant Professor of Neurology
Department: Neurology
Graduate Group Affiliations

Contact information
The Children's Hospital of Philadelphia
Division of Neurology
Abramson Research Center, Room 502A
3615 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-590-6894
Fax: 215-590-1771
Lab: 215-590-5671
Education:
B.A. (Neurobiology)
Harvard University, 1999.
Ph.D. (Physiology & Neuroscience)
New York University School of Medicine, 2006.
M.D. (Medicine)
New York University School of Medicine, 2008.
Permanent link
 

Description of Research Expertise

Epilepsy; Neurobiology of Disease; Physiology; Ion channels; Two-photon imaging.

Selected Publications

Goldberg, E.M.: Getting a foot IN the door: GABAergic INterneuron-specific enhancers. Epilepsy Currents doi: 10.1177/1535759720985841, Online ahead of print 2021.

Helbig, I., Goldberg, E.M.: The dose makes the poison – novel insights into Dravet Syndrome and SCN1A regulation through non-productive splicing. PLOS Genetics doi.org/10.1371/journal.pgen.1009214 2021.

Zaman, T., Helbig, K.L., Clatot, J., Thompson, C.H., Kang, S.K., Stouffs, K., Jansen, A.E., Verstraete, L., Jacquinet, A., Parrini, E., Guerrini, R., Fujiwara, Y., Miyatake, S., Ben-Zeev, B., Bassan, H., Reish, O., Marom, D., Hauser, N., Vu, T.A., Ackermann, S., Spencer, C.E., Lippa, N., Srinivasan, S., Charzewska, A., Hoffman-Zacharska, D., Fitzpatrick, D., Harrison, V., Vasudevan, P., Joss, S., Pilz, D.T., Fawcett, K.A., Helbig, I., Matsumoto, N., Kearney, J.A., Fry, A.E., Goldberg, E.M. : SCN3A-related neurodevelopmental disorder: A spectrum of epilepsy and brain malformation. Ann Neurol 88(2): 348-362, August 2020.

Goldberg EM: Gene Therapy in Models of Severe Epilepsy due to Sodium Channelopathy. Epilepsy Currents 20(4): 214-217, June 2020.

Tran, C.H., Vaiana, M., Nakuci, J., Somarowthu, A., Goff, K.M., Goldstein, N., Murthy, P., Muldoon, S.F., Goldberg, E.M.: Interneuron desynchronization precedes seizures in a mouse model of Dravet syndrome. Journal of Neuroscience 40(13): 2764-2775, May 2020.

Qian X, Su Y, Adam CD, Deutschmann AU, Pather SR, Goldberg EM, Su K, Li S, Lu L, Jacob F, Nguyen PTT, Huh S, Hoke A, Swinford-Jackson SE, Wen Z, Gu X, Pierce RC, Wu H, Briand LA, Chen HI, Wolf JA, Song H, Ming GL: Sliced Human Cortical Organoids for Modeling Distinct Cortical Layer Formation. Cell Stem Cell 26(5): 766-781, May 2020.

Somarowthu, A, Goldberg, EM: 2P or not 2P: The Question of Seizure Initiation. Epilepsy Currents Online ahead of print 2020.

Kang, S.K., Vanoye, C.G., Misra, S.N., Echevarria, D.M., Calhoun, J.D., O’Connor, J.B., Fabre, K., McKnight, D., Demmer, L., Goldenberg, P., Grote, L.E., Strauss, K., Torkmani, A., can de Smagt, J., Carson, R., Diaz, J., Jacker, J. Litwin, J., Friedman, N., Schreiber, A., Poduri, A., Marsh, E., Goldberg, E.M., Millichap, J.J., George, A.L., Kearney, J.A. : Dysfunction in KCNB1-Associated Neurodevelopmental Disorders. Ann Neurol 86(6): 899-912, December 2019.

Li, J., Ryan, S., Deboer, E., Cook, K., Fitzgerald, S., Lachman, H., Wallace, D., Goldberg, E.M., Anderson, S.A. : Mitochondrial deficits in human iPSC-derived neurons from patients with 22q11.2 deletion syndrome and schizophrenia. Transl Psych 9(1): 302, November 2019.

Chu, J., Fitzgerald, M.L., Sehgal, N., Manley, W., Fitzgerald, S., Naung, H., Goldberg, E.M., Anderson, S.A. : Enhanced maturation of human stem cell derived interneurons by mTOR activation. bioRxiv Page: https://doi.org/10.1101/777714, November 2019.

back to top
Last updated: 01/11/2021
The Trustees of the University of Pennsylvania