Faculty

Brian R White, MD, PhD

Assistant Professor of Pediatrics (Cardiovascular Medicine)

Department: Pediatrics

Graduate Group Affiliations

Neuroscience

Contact information

Children's Hospital of Philadelphia
Abramson Research Center, 907C
3615 Civic Center Blvd.
Philadelphia, PA 19104

Office: 267-283-7835
Fax: 215-590-5825
Lab: 215-590-3548

Email:
brian.white@post.harvard.edu

Publications

Search PubMed for articles

Education:
BA (Physics)
Harvard University, 2004.
MD
Washington University School of Medicine in St. Louis, 2012.
PhD (Physics)
Washington University School of Medicine in St. Louis, 2012.

Links
Search PubMed for articles
ORCID Profile
NCBI bibliography
Lab Webpage
Google Scholar Profile

Permanent link

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Description of Research Expertise

My laboratory is interested in developing novel optical neuroimaging techniques to better understand pediatric neurodevelopment and its disruption by pediatric diseases (congenital heart disease, prematurity, stroke). Namely, we use optical intrinsic signal (OIS) imaging and diffuse optical tomography (DOT) along with resting-state methods such as functional connectivity. This combination of methods allows true bench-to-bedside neuroimaging. Specifically, my laboratory is interested in analytical technique development, animal models of pediatric disease, and translational studies in humans.

Selected Publications

Arjun Yodh, Emilie Benson, Danielle Aronowitz, Rodrigo Forti, Alec Lafontant, Nicolina Ranieri, Jonathan Starr, Richard Melchior, Alistair Lewis, Jharna Jahnavi, Jake Breimann, Bohyun Yun, Gerard Laurent, Jennifer Lynch, Brian White, J. Gaynor, Daniel Licht, Todd Kilbaugh, Constantine Mavroudis, Wesley Baker, Tiffany Ko,: Hematocrit Correction for Diffuse Optical Monitoring of Cerebral Blood Flow and Oxygen Metabolism during Cardiopulmonary Bypass. Optica Biophotonics Congress 2024.

H.M. Stanley, B.R. White, C.J. LaRosa, M.W. Cocalis, J.W. Gaynor, A. Strong, B. Gangaram: Patent Ductus Arteriosus and Coarctation of the Aorta in Association with PRDM6 Variants. American Journal of Medical Genetics Part A in press, 2024.

Hayden Fisher, Aurora Yuan, Brian White: A Multi-Atlas Machine Learning Approach for Automated Segmentation of Widefield Optical Imaging in Mice. Optica Biophotonics Congress 2024.

Wesley Baker, Rodrigo Forti, Brian White, Jennifer Lynch, Arjun Yodh, Todd Kilbaugh, Tiffany Ko: Modified Beer-Lambert Algorithm to Improve the Pulsatile Diffuse Correlation Spectroscopy Blood Flow Signal. Optica Biophotonics Congress 2024.

Sarah Lavery, Temilola Adepoju, Hayden Fisher, Claudia Chan, Aurora Yuan, Amanda Kuhs, Rebecca Ahrens-Nicklas, Brian White: Functional Connectivity Changes in Mouse Models of Maple Syrup Urine Disease. Optica Biophotonics Congress 2024.

Temilola Adepoju, Hayden Fisher, Chloe Winston, Brian White: Intact-Skull Cranial Windows for Widefield Imaging in Juvenile Mice: Complications and Impact on Skull Growth. Optica Biophotonics Congress 2024.

Aurora Yuan, Hayden Fisher, Jonah Padawer-Curry, Adam Bauer, Brian White: An independent replicability study of MesoNet for automated segmentation and landmark identification in functional widefield optical imaging in mice. Optica Biophotonics Congress 2024.

B.R. White, T.E. Adepoju, H.B. Fisher, R.T. Shinohara, S.Vandekar: Spatial Nonstationarity of Image Noise in Widefield Optical Imaging and Its Effects on Cluster-Based Inference for Resting-State Functional Connectivity. Journal of Neuroscience Methods 404: 110076, 2024.

B.R. White, C. Chan, T. Adepoju, S. Da Silva, E.K. Shih: Evolution of ischemic stroke assessed with resting-state hemodynamics in mice. SPIE Photonics West 2023.

W.B. Baker, R. Forti, P. Heye, K. Heye, N.R. Ranieri, E. Benson, Y. Lin, K.N. Andersen, J. Jahnavi, J. Breimann, H. Gaudio, J.M. Lynch, A.G. Yodh, D.J. Licht, B.R. White, M. Hwang, T.J. Kilbaugh, T.S. Ko: Diffuse optical metrics of intracranial hypertension in a pig model of hydrocephalus. European Conferences on Biomedical Optics 2023.