Faculty
Brian R White, MD, PhD
Assistant Professor of Pediatrics (Cardiology)
Department: Pediatrics
Graduate Group Affiliations
Contact information
Children's Hospital of Philadelphia
Abramson Research Center, 907C
3615 Civic Center Blvd.
Philadelphia, PA 19104
Abramson Research Center, 907C
3615 Civic Center Blvd.
Philadelphia, PA 19104
Office: 267-283-7835
Fax: 215-590-5825
Lab: 215-590-3548
Fax: 215-590-5825
Lab: 215-590-3548
Email:
brian.white@post.harvard.edu
brian.white@post.harvard.edu
Publications
Education:
BA (Physics)
Harvard University, 2004.
MD
Washington University School of Medicine in St. Louis, 2012.
PhD (Physics)
Washington University School of Medicine in St. Louis, 2012.
Permanent linkBA (Physics)
Harvard University, 2004.
MD
Washington University School of Medicine in St. Louis, 2012.
PhD (Physics)
Washington University School of Medicine in St. Louis, 2012.
Description of Research Expertise
My laboratory is interested in developing novel optical neuroimaging techniques to better understand pediatric neurodevelopment and its disruption by pediatric diseases (congenital heart disease, prematurity, stroke). Namely, we use widefield optical imaging (WOI) in mice and diffuse optical tomography (DOT) in large animals and humans to probe brain function. Our analysis methods focus on resting-state methods (e.g., functional connectivity) as a way to probe brain integrity at the bedside. We are also interesting in algorithm development, including new statistical methods to ensure rigor and reproducibility. We collaborate with many researchers at CHOP and Penn including biostatisticians, optical imagers, and labs that develop animal models of disease.Selected Publications
BR White, AT Subhash, D Derman, HB Fisher, SA Paladugu, A Crozier, TS Ko, SL Ferradal: First-in-Large-Animal Diffuse Optical Tomography: Hardware and Pipeline for Peri-Arrest Monitoring in Piglets. fNIRS 2026: Biennial Meeting of the Society for Functional Near-Infrared Spectroscopy Oct 2026 Notes: Macau, China.Y Hao, SN Vandekar, T Satterthwaite, BR White, RT Shinohara: Addressing Group Effects in the SPICE Test for Intermodal Correspondence. Joint Statistical Meeting Aug 2026 Notes: Boston, MA.
Y Hao, SN Vandekar, BR White, RT Shinohara: Interaction Between Subject and Group Effects in the SPICE Test for Intermodal Correspondence. Organization for Human Brain Mapping Annual Meeting Jun 2026 Notes: Bordeaux, France.
Y Hao, O Harel, SN Vandekar, RT Shinohara, BR White: Imputing Missing Neuroimaging Data While Maintaining Spatial Autocorrelation. Statistics in Medical Imaging Conference June 2026 Notes: Ann Arbor, MI.
S Kejriwal, Y Hao, BR White: Evaluating the Performance of the SPICE Test Under Heterogeneous Spatial Autocorrelation. Statistics in Medical Imaging Conference June 2026 Notes: Ann Arbor, MI.
J Zhang, A Palmucci, H Fisher, RM Forti, BR White: Subject-Specific Monte Carlo Modeling of Photon Transport for Optical Neuroimaging in Mice. Organization for Human Brain Mapping Annual Meeting Jun 2026 Notes: Bordeaux, France.
Y Hao, O Harel, SN Vandekar, RT Shinohara, BR White: Imputing Missing Neuroimaging Data while Maintaining Spatial Autocorrelation. Organization for Human Brain Mapping Annual Meeting Jun 2026 Notes: Bordeaux, France.
M Gautier, S Bhuyan, A Palmucci, MG Alameh, X Hong, X Wang, K Musunuru, BR White, and Rebecca Ahrens-Nicklas: In vivo adenine base editing of the liver rescues neurologic deficits in a mouse model of phenylketonuria (PKU). ASGCT Annual Meeting May 2026 Notes: Boston, MA.
J Zhang, A Palmucci, H Fisher, RM Forti, BR White: Subject-Specific Monte Carlo Modeling for Optical Neuromonitoring and Neuroimaging in Mice. Optica Biophotonics Congress Apr 2026 Notes: Ft. Lauderdal, FL.
Y Hao, O Harel, SN Vandekar, RT Shinohara, BR White: Maintaining Spatial Autocorrelation During Imputation of Missing Neuroimaging Data. Optica Biophotonics Congress Apr 2026 Notes: Ft. Lauderdale, FL.
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