Stewart A Anderson, MD

faculty photo
Professor of Psychiatry
Department: Psychiatry
Graduate Group Affiliations

Contact information
3615 Civic Center Blvd.
Abramson Research Center
Room 517
Philadelphia, PA 19147
Office: 215-590-6527
Fax: 215-590-3709
BA (Neuroscience and Psychology)
Amherst College, Amherst, MA, 1984.
MD (Medicine)
University of Connecticut, Storrs, CT, 1989.
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Description of Research Expertise

I am a Children's Hospital of Philadelphia-based faculty in the Department of Psychiatry at UPenn.
The focus of my laboratory concerns the molecular and cellular mechanisms that govern the development of the mammalian forebrain. We use mouse genetics, forebrain slice and dissociated culture techniques, as well as mouse and human pluripotent stem cells in cell culture and transplantation experiments to study the fate determination of interneurons of the cerebral cortex. We are particularly interested in understanding the molecular underpinnings behind the fate determination of subclasses of GABAergic interneurons implicated in the neuropathology of autism and schizophrenia. In addition, we are using mouse and human stem cell-derived interneurons in animal models of cell-based therapies for seizures, psychosis, and as tools for the study of gene-gene and gene-environment interactions in neuropsychiatric disease. Additional projects include the study of mitochondria in stem cell derived neurons derived from people with the 22q11.2 deletion syndrome and schizophrenia, and the study of human stem cell derived microglia infected with HIV.
For more information, please visit the Anderson lab website at:

Selected Publications

Crockett AM, Kebir. H, Benallegue, Adelman P, Gur RE, Sullivan S, Anderson SA, Alvarez JI : Immune status of the murine 22q11.2 deletion syndrome model European Journal of Immunology 53(1): https://doi.org/10.1002/eji.202249840, January 2023.

Cristancho AG, Gadra EC, Samba IM, Zhao C, Ouyang M, Magnitsky S, Huang H, Viaene AN, Anderson SA, Marsh ED.: Deficits in seizure threshold and other behaviors in adult mice without gross neuroanatomic injury after late gestation transient prenatal hypoxia. Dev Neurosci Mar 2022.

Cook K, Anderson SA: Genesis and migration of cerebral cortical inhibitory interneurons: an overview. Chapter 186 in; Chapter 186 in Neuroscience in the 21st Century. D. Pfaff (eds.). Springer Nature, in press 2022.

Singh LN, Ennis B, Loneragan B, Tsao NL, Lopez Sanchez MIG, Li J, Acheampong P, Tran O, Trounce IA, Zhu Y, Potluri P; Regeneron Genetics Center, Emanuel BS, Rader DJ, Arany Z, Damrauer SM, Resnick AC, Anderson SA, Wallace DC.: MitoScape: A big-data, machine-learning platform for obtaining mitochondrial DNA from next-generation sequencing data. PLoS Comput Biol 17: e1009594, Nov 2021.

Li J, Tran OT, Crowley TB, Moore TM, Zackai EH, Emanuel BS, McDonald-McGinn DM, Gur RE, Wallace DC, Anderson SA.: Association of Mitochondrial Biogenesis With Variable Penetrance of Schizophrenia. JAMA Psychiatry 78: 911-921, Aug 2021.

Crockett AM, Ryan SK, Vásquez AH, Canning C, Kanyuch N, Kebir H, Ceja G, Gesualdi J, Zackai E, McDonald-McGinn D, Viaene A, Kapoor R, Benallegue N, Gur R, Anderson SA, Alvarez JI.: Disruption of the blood-brain barrier in 22q11.2 deletion syndrome. Brain 144: 1351-1360, Jun 2021.

Ryan SK, Jordan-Sciutto KL, Anderson SA.: Protocol for Tri-culture of hiPSC-Derived Neurons, Astrocytes, and Microglia. STAR Protoc 1: 100190, Dec 2020.

Kahn JB, Port RG, Anderson SA, Coulter DA.: Modular, Circuit-Based Interventions Rescue Hippocampal-Dependent Social and Spatial Memory in a 22q11.2 Deletion Syndrome Mouse Model. Biol Psychiatry 88: 710-718, Nov 2020.

Ryan SK, Gonzalez MV, Garifallou JP, Bennett FC, Williams KS, Sotuyo NP, Mironets E, Cook K, Hakonarson H, Anderson SA, Jordan-Sciutto KL.: Neuroinflammation and EIF2 Signaling Persist despite Antiretroviral Treatment in an hiPSC Tri-culture Model of HIV Infection. Stem Cell Reports 14: 703-716, Apr 2020.

Fitzgerald M, Sotuyo N, Tischfield DJ, Anderson SA.: Generation of cerebral cortical GABAergic interneurons from pluripotent stem cells. Stem Cells 2020.

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Last updated: 08/14/2023
The Trustees of the University of Pennsylvania