Delia Maria Talos, MD

faculty photo
Research Associate Professor of Neurology
Department: Neurology
Graduate Group Affiliations

Contact information
University of Pennsylvania
Perelman School of Medicine
263 Clinical Research Building
415 Curie Boulevard
Philadelphia, PA 19104
Office: 215-573-8328
Fax: 215-662-3362
MD (Medicine)
University of Cologne, Germany, 1992.
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Description of Research Expertise

1) Key words: epilepsy, neurodevelopment, aging, neuroinflammation

2) Research interests: Neuronal and glial development, synaptic function, epilepsy, autism, cognition.

3) Research techniques: Quantitative protein and gene expression, immunohistochemistry, fluorescence microscopy, transgenic animals, EEG recordings, mouse behavior

4) Research summary: My research focuses on understanding the cellular and molecular mechanisms of epilepsy and its associated neuropsychiatric co-morbidities, with a particular emphasis on genetic, immunological and neurodegenerative processes. The laboratory uses both human brain samples and translational mouse models to study and treat genetic epilepsies such as Tuberous Sclerosis Complex and CDKL5 deficiency disorder, as well as more common forms of epilepsy, caused by status epilepticus, traumatic brain injury and neurodegenerative brain disorders.

Selected Publications

Roberts NS, Handy MJ, Ito Y, Hashimoto K, Jensen FE, Talos DM: Anti-seizure efficacy of perampanel in two established rodent models of early-life epilepsy. Epilepsy Behavior 143: 109194, Jun 2023.

Fukushima K, Higashiyama H, Kazuta Y, Hashimoto K, Watanabe N, Furuya Y, Ito Y, Wu T, Kosasa T, Talos DM, Song Y, Roberts NS, Jensen FE, Hanada T, Ido K: Discovery of E2730, a novel selective uncompetitive GAT1 inhibitor, as a candidate for anti-seizure medication. Epilepsia Open Online ahead of print, Apr 2023.

Barbour AJ, Gourmaud S, Li X, Stewart D, Irwin DJ, Talos DM, Jensen FE : Seizures exacerbate excitatory: inhibitory imbalance in Alzheimer’s disease with attenuation after rapamycin treatment. bioRxiv Mar 2023 Notes: doi: https://doi.org/10.1101/2023.03.02.530499.

Juul HM, Brooks-Kayal AR, Talos DM: Why do febrile seizures involve specifically the developing brain? Febrile Seizures, 2nd edition. Tallie Z. Baram, Shlomo Shinnar and Carl E. Stafstrom (eds.). UK: Academic Press, Page: 155-178, Sept 2022 Notes: Chapter 9.

Xu HN*, Gourmaud S, Podsednik A, Li X, Zhao H, Jensen FE, Talos DM*, Li LZ*: Optical Redox Imaging of Ex Vivo Hippocampal Tissue Reveals Age-Dependent Alterations in the 5XFAD Mouse Model of Alzheimer's Disease. Metabolites 12(9): 786, Aug 2022 Notes: *Equal contribution.

Gourmaud S, Stewart DA, Irwin DJ, Roberts NS, Barbour AJ, Eberwine G, O'Brien WT, Vassar R, Talos* DM, Jensen FJ*: The role of mTORC1 activation in seizure-induced exacerbation of Alzheimer's disease. Brain 145(1): 324-339, Mar 2022 Notes: *Equal contribution.

Xu HN, Gourmaud S, Podsednik A, Li X, Zhao H, Jensen FE, Talos DM, Li LZ: Optical redox imaging of ex vivo hippocampal slices differentiates normal from Alzheimer’s disease in mouse models World Molecular Imaging Congress, Miami Beach, FL 2022 Notes: Oral presentation.

Li X, Gourmaud S, Shrayer E, Barbour AJ, Irwin DJ, Jensen FE, Talos DM: Seizures in Alzheimer's disease are associated with increased microglial activation Society for Neuroscience, Chicago, IL. Neuroscience Meeting Planner. Program No.195.16. Online 2022 Notes: Poster.

Li LZ, Nath K, Arias-Mendoza F, Xu HN, Jensen FE, Talos DM: In vivo 31P-MRS reveals NAD deficiency in a mouse model of Alzheimer’s disease. The World Molecular Imaging Congress, Miami Beach, FL 2022 Notes: Oral presentation.

Rodemer W, Juul H, Mehta S, Farag M, Porta S, Talos DM, Lee VM-Y: Seizures in a doxycycline-regulatable mouse model of TDP-43 proteinopathy. Society for Neuroscience, Chicago, IL. Neuroscience Meeting Planner. Program No 537.03. Online 2022 Notes: Poster.

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Last updated: 07/17/2023
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