Faculty

Delia Maria Talos, MD

faculty photo
Research Assistant Professor of Neurology
Department: Neurology
Graduate Group Affiliations

Contact information
University of Pennsylvania
Perelman School of Medicine
263 Clinical Research Building
415 Curie Boulevard
Philadelphia, PA 19104
Office: 215-573-8328
Fax: 215-662-3362
Education:
MD (Medicine)
University of Cologne, Germany, 1992.
Permanent link
 

Description of Research Expertise

1) Key words: epilepsy, neurodevelopment, aging, neuroinflammation

2) Research interests: Neuronal and glial development, synaptic function, epilepsy, autism, cognition.

3) Research techniques: Quantitative protein and gene expression, immunohistochemistry, fluorescence microscopy, transgenic animals, EEG recordings, mouse behavior

4) Research summary: My research focuses on understanding the cellular and molecular mechanisms of epilepsy and its associated neuropsychiatric co-morbidities, with a particular emphasis on genetic, immunological and neurodegenerative processes. The laboratory uses both human brain samples and translational mouse models to study and treat genetic epilepsies such as Tuberous Sclerosis Complex and CDKL5 deficiency disorder, as well as more common forms of epilepsy, caused by status epilepticus, traumatic brain injury and neurodegenerative brain disorders.

Selected Publications

Isaacs D, Barbour A, Irwin DJ, Jensen FE, Talos, DM: Microglial dysfunction in comorbid Alzheimer's disease and seizures. American Neurological Association Annual Meeting (virtual conference) 2021.

Gourmaud S, Stewart DA, Irwin DJ, Roberts NS, Barbour AJ, Eberwine G, O'Brien WT, Vassar R, Talos DM, Jensen FJ.: The role of mTORC1 activation in seizure-induced exacerbation of Alzheimer's disease. Brain 2021 Notes: Online ahead of print.

Barbour, AJ, Isaacs D, jensen, FE, Talos, DM: Epilepsy contributes to Alzheimer's disease white matter pathology and dysregulates microglial function. American Epilepsy Society Meeting, Chicago, IL 2021.

Barbour AJ, Isaacs D, Li X, Irwin DJ, jensen, FE, Talos, DM: Alzheimer's disease risk factors are further dysregulated in patients with seizure history. Society for Neuroscience meeting, Chicago, IL 2021.

Gourmaud S, Shou H, Irwin DJ, Sansalone K, Jacobs LM, Lucas TH, Marsh ED, Davis KA, Jensen FE* Talos DM*. : Alzheimer-like amyloid and tau alterations associated with cognitive deficit in temporal lobe epilepsy Brain 143(1): 191–209, 2020 Notes: *Equal contribution.

Song Y, Jensen FE, Talos DM: Developmental expression of neuronal chloride transporters in different brain regions and sensory organs. Neuronal Chloride Transporters in Health and Disease. Xin Tang (eds.). UK: Academic Press, Page: 215-242, 2020.

Jones JE, Asato MR, Brown MG, Doss JL, Felton EA, Kearney JA, Talos DM, Dacks PA, Whittemore V*, Poduri A* : Epilepsy Benchmarks Area IV: Limit or Prevent Adverse Consequence of Seizures and Their Treatment Across the Lifespan Epilepsy Currents Vol. 20(1S): 31S-39S, 2020 Notes: *For the NINDS/AES Benchmarks Stewards Committee

Gourmaud S, Eberwine G, Vassar RJ, Talos DM, Jensen FE : Exacerbation of Alzheimer's Disease Neuropathology by Induced Seizures in the 5XFAD Mouse Model American Epilepsy Society Meeting, Baltimore, MA. Abstract Viewer Abst. 1.287 2019.

Massa S, Sansalone K, Gourmaud S, Lucas T, Jensen FE, Davis KA, Talos DM. : Dysregulation of Glutamate-Glutamine Cycle Transporters in Human Drug-Resistant Epilepsy American Epilepsy Society Meeting, Baltimore, MA. Abstract Viewer Abst. 1.087. 2019 Notes: Poster.

Roberts N, Ito Y, Talos DM, Jensen FE. : Effects of Perampanel on Hyperthermia-Induced Seizures in a Dravet Syndrome Mouse Model. American Epilepsy Society Meeting, Baltimore, MA. Abstract Viewer Abst. 2.198. 2019 Notes: Poster.

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Last updated: 08/11/2021
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