Faculty

Jeffrey Scott Phillips, PhD

Research Assistant Professor of Neurology

Department: Neurology

Graduate Group Affiliations

Neuroscience

Contact information

B602 Richards
Penn Frontotemporal Degeneration Center
3700 Hamilton Walk
Philadelphia, PA 19104

Email:
jefphi@pennmedicine.upenn.edu

Publications

Search PubMed for articles

Education:
BA (English & Honors)
Villanova University, 1997.
MS (Cognitive psychology)
University of Pittsburgh, 2009.
PhD (Cognitive psychology)
University of Pittsburgh, 2012.

Links
Search PubMed for articles
Github site for academic research projects
Penn Frontotemporal Degeneration Center profile

Permanent link

SOM Home » BGS Home » NGG Home » Faculty

Description of Research Expertise

Atypical Alzheimer's disease
Frontotemporal dementia

Magnetic resonance imaging (MRI)
Positron emission tomography (PET): amyloid and tau
Computational neuroimaging
Statistical programming (R, Python)

Selected Publications

Jeffrey S. Phillips, Dahlia Kamel, Sevila Temirova, Marianthi Hareras, Chigozie Ibe, Quinn Hlava, Emily Xie, Katheryn A. Q. Cousins, Leslie M. Shaw, Sandhitsu R. Das, Jeffrey Maneval, Sara Manning, Christopher Brown, Katherine Lopez, Richard Keegan, Andrew Stephens, Corey T. McMillan, David J. Irwin, Liz Li, Ilya M. Nasrallah, and David A. Wolk: [18F]-PI-2620 uptake in the medial temporal lobes discriminates Alzheimer's disease from normal cognition and non-Alzheimer's dementias. Human Amyloid Imaging 2025.

Shen, T., Vogel, J. W., Van Deerlin, V. M., Suh, E., Dratch, L., Phillips, J. S., Massimo, L., Lee, E. B., Irwin, D. J., & McMillan, C. T.: Disparate and shared transcriptomic signatures associated with cortical atrophy in genetic behavioral variant frontotemporal degeneration. Molecular Degeneration 20(1): 17, 2025.

Kim, B. J., Aleman, T. S., Cousins, K. A. Q., Daniel, E., Smith, E., Iacobucci, E., Kolomeyer, A., Hwang, C. K., McMillan, C. T., Van Deerlin, V. M., Phillips, J. S., Yu, Y., Ying, G.-S., & Irwin, D. J.: Choroidal evaluation of FTLD-Tau and biomarker-determined Alzheimer’s disease. Scientific Reports 15(1): 22290, 2025.

Watanabe, R., Papatriantafyllou, J. D., Maeda, K., Aguirre, G. K., Ando, M., Benoit, B., Grossman, M., Irwin, D. J., Kim, B., Massimo, L., McMillan, C. T., Papageorgiou, S. G., Phillips, J. S., Shiraishi, T., Sugihara, Y., Suh, E., Takashima, H., Toro, C., Van Deerlin, V. M., Nasrallah, I. M., and Lee, E. B.: Clinicopathological characterization of vacuolar tauopathy associated with VCP D395G. Alzheimer’s & Dementia 21(7): e70427, 2025.

Jesse S Cohen, Jeffrey Phillips, Sandhitsu R Das, Christopher A Olm, Hamsanandini Radhakrishnan, Emma Rhodes, Katheryn AQ Cousins, Sharon X Xie, Ilya M Nasrallah, Paul A Yushkevich, David A Wolk, Edward B Lee, Daniel Weintraub, David J Irwin, and Corey T McMillan: Posterior hippocampal sparing in Lewy body disorders with Alzheimer’s copathology: An in vivo MRI study. NeuroImage: Clinical 45(103714), 2025.

Katheryn Alexandra Quilico Cousins, David J Irwin, Thomas F Tropea, Emma Rhodes, Jeffrey S Phillips, Alice Chen-Plotkin, Michael C Brumm, Christopher S Coffey, Ju Hee Kang, Tanya Simuni, Tatiana Foroud, Arthur W Toga, Caroline M Tanner, Karl Kieburtz, Brit M Mollenhauer, Douglas R Galasko, Samantha Hutten, Daniel Weintraub, Andrew Siderowf, Kenneth Marek, Kathleen L Poston, Leslie M Shaw, Parkinson's Progression Marker Initiative: Evaluation of ATN-PD framework and biofluid markers to predict cognitive decline in early Parkinson's disease. Neurology 102(4): e208033, Feb 2024 Notes: doi: 10.1212/WNL.0000000000208033.

Jeffrey S. Phillips, John L. Robinson, Katheryn A. Q. Cousins, David A. Wolk, Edward B. Lee, Corey T. McMillan, John Q. Trojanowski, Murray Grossman, and David J. Irwin: Polypathologic associations with grey matter atrophy in neurodegenerative disease. Journal of Neuroscience 44(6): e0808232023, Feb 2024

Rhodes E, Mechanic-Hamilton D, Phillips JS, Bahena A, Vitali N, Hlava Q, Cook P, Gee J, Grossman M, McMillan C, Massimo L: Discrepancies in patient and caregiver ratings of personality change in Alzheimer’s disease and related dementias. Archives of Clinical Neuropsychology 39(4): 399-408, May 2024.

Cousins, K.A., Phillips, J.S., Das, S.R., O'Brien, K., Tropea, T.F., Chen‐Plotkin, A., Shaw, L.M., Nasrallah, I.M., Mechanic‐Hamilton, D., McMillan, C.T. and Irwin, D.J.: Pathologic and cognitive correlates of plasma biomarkers in neurodegenerative disease. Alzheimer's & Dementia 20(6): 3889-3905, Apr 2024 Notes: https://doi.org/10.1002/alz.13777.

Arezoumandan S, Cousins KAQ, Ohm DT, Lowe M, Chen M, Gee J, Phillips JS, McMillan CT, Luk KC, Deik A, Spindler MA, Tropea TF, Weintraub D, Wolk DA, Grossman M, Lee V, Chen-Plotkin AS, Lee EB, Irwin DJ.: Tau maturation in the clinicopathological spectrum of Lewy body and Alzheimer's disease. Annals of Clinical and Translational Neurology 11(3): 673-685, Mar 2024.