Faculty

Beverly L. Davidson, Ph.D.

faculty photo
Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
The Children's Hospital of Philadelphia
3501 Civic Center Boulevard, 5060 CTRB
Philadelphia, PA 19104
Office: 267-426-0929
Fax: 215-590-3660
Education:
B.S. (Biology Major/Chemistry Minor; High Distinction)
Nebraska Wesleyan University, 1981.
Ph.D. (Biological Chemistry)
University of Michigan, 1987.
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Description of Research Expertise

Keywords:
Neurodegenerative Disease
RNA biology
Gene therapy
Animal models
Human treatment

Our lab is focused on genetic diseases that affect the brain. We study the mechanisms by which mutant gene products contribute to disease, and why certain brain regions are more susceptible. The team employs advanced molecular methods, sequencing and imaging modalities in animal models. The lab is also engaged in the development of next generation therapeutics for inherited disorders, including the engineering of novel gene therapy vector capsids and cargo to approach tissue and cell type specific treatments.

Selected Publications

Tecedor L, Chen Y, Leib DE, Ranum PT, Simpson BP, Keiser MG, McFadden M, Mackiewicz A, Lewandowski B, Lysenko E, Cha J-H, Davidson BL: AAV-EP+ in Preclinical Studies for Late Infantile Neuronal Ceroid Lipofuscinosis. Presented at the 27th Annual Meeting of the American Society for Gene and Cell Therapy, Baltimore, MD May 2024.

Robbins A, Chen Y, Lewandowski B, Houserova D, Ranum PT, Tecedor L, Davidson BL: AAV Capsid Selection at Spatial and Single-Cell Resoloution in Non-Human Primate Retina. Presented at the 27th Annual Meeting of the American Society for Gene and Cell Therapy, Baltimore, MD May 2024.

Ranum PT, Carrell E, Devare J, Tecedor L, Chen Y, Giovenco R, Monteys AM, Chorney SR, O'Reilly RC, Davidson BL : Cochlear Gene Therapy Innovations: AAV Capsid Variants and Cell Type-Specific Regulatory Elements to Facilitate CSF-Mediated Administration. Presented at the 27th Annual Meeting of the American Society for Gene and Cell Therapy, Baltimore, MD May 2024.

Leib DE, Chen YH, Tecedor L, Ranum PT, Keiser MS, Lewandowski BC, Carrell EM, Arora S, Huerta-Ocampo I, Liu X, Davidson BL: Optimized AAV capsids for diseases of the basal ganglia show robust potency and distribution in adult nonhuman primates. bioRxiv Page: 05.02.592211, May 2024 Notes: doi: https://doi.org/10.1101/2024.05.02.592211.

Jackson RJ, Keiser MS, Meltzer JC, Fykstra DP, Dierksmeier SE, Hajizadeh S, Kreuer J, Morris R, Melloni A, Nakamima T, Tecedor L, Ranum PT, Carrell E, Chen Y, Nishtar MA, Holtzman DM, Haas W, Davidson BL, Hyman BT: APOE2 gene therapy reduces amyloid deposition, and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease. Mol Ther 32(5): 1373-1386, May 2024.

Arora S, O'Driscoll E, Lang J, Davidson BL, Shalem O: CRISPR Screen for rAAV Production Implicates Genes Associated with Infection Presented at the 27th Annual Meeting of the American Society for Gene and Cell Therapy, Baltimore, MD May 2024.

Arora S, Waxman EA, Dungan LV, French DL, Prosser BL, Davidson BL: Rescuing STXBP1 Haploinsuffiency in Patient Derived iPSCs using AAV Mediated Gene Replacement. Presented at the 27th Annual Meeting of the American Society for Gene and Cell Therapy, Baltimore, MD May 2024.

Cooney AL, Chen Y, Lewandowski B, Newase PK, Davidson BL, McCray PB: Enhancing Airway Transduction Using AAV Equipped with Advanced Barcoding Methods for CF Gene Therapy. Presented at the 27th Annual Meeting of the American Society for Gene and Cell Therapy, Baltimore, MD May 2024.

Giovenco RC, Montes AM, Carrell E, Davidson BL: miXon, a System for Tunable Control of miRNA Expressio by Drug-Induced Splicing. Presented at the 27th Annual Meeting of the American Society for Gene and Cell Therapy, Baltimore, MED May 2024.

Romano LEL, Preston C, Ortiz T, Ajeridini R, Golliher H, Carrell E, Keiser M, Ames A, Davidson BL, Ranum LPW: AAV-Based anti-RAN Antibody Therapy for C9orf72 ALSFTD. Presented at the 27th Annual Meeting of the American Society for Gene and Cell Therapy, Baltimore, MD May 2024.

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Last updated: 06/18/2024
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