Alexander Proekt, M.D. Ph.D.

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Assistant Professor of Anesthesiology and Critical Care
Department: Anesthesiology and Critical Care
Graduate Group Affiliations

Contact information
Anesthesiology and Critical Care
University of Pennsylvania
331 John Morgan Building
Philadelphia, PA 19104
Lab: 215 746 2370
B.S. (Biological Sciences)
Carnegie Mellon University, 1998.
M.D. Ph.D. (Neuroscience/Medicine)
Mount Sinai School of Medicine, 2006.
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Description of Research Expertise

Neuroscience, Neurophysiology, Computational Neuroscience, Systems Neuroscience

Selected Publications

McKinstry-Wu AR, Wasilczuk AZ, Harrison BA, Bedell VM, Sridharan MJ, Breig JJ, Pack M, Kelz MB, Proekt A: Analysis of stochastic fluctuations in responsiveness is a critical step toward personalized anesthesia. eLife 8: e50143 DEC 2019 Notes: Electronic Journal; https://doi.org/10.7554/eLife.50143.

Proekt A, Hemmings H: Mechanisms of Drug Action. Pharmacology and Physiology for Anesthesia, 2nd Ed. Hemmings H, Egan T (eds.). Elsevier, Page: 2-18, NOV 2019.

Shortal BP, Hickman LB, Mak-McCully RA, Wang W, Brennan C, Ung H, Litt B, Tarnal V, Janke E, Picton P, Blain-Moraes S, Maybrier HR, Muench MR, Lin N, Avidan MS, Mashour GA, McKinstry-Wu AR, Kelz MB, Palanca BJ, Proekt A: Duration of EEG suppression does not predict recovery time or degree of cognitive impairment after general anaesthesia in human volunteers. British Journal of Anaesthesia 123(2): 206-218, AUG 2019.

Gao S, Proekt A, Renier N, Calderon D, Pfaff D : Activating an anterior nucleus gigantocellularis subpopulation triggers emergence from pharmacologically-induced coma in rodents. Nature Communications 10(1), JUL 2019.

Brennan C, Proekt A: A quantitative model of conserved macroscopic dynamics predicts future motor commands. eLife 8: e46814, JUL 2019 Notes: Electronic Journal; https://elifesciences.org/articles/46814.

Aggarwal A, Brennan C, Shortal B, Contreras D, Kelz MB, Proekt A: Coherence of Visual-Evoked Gamma Oscillations Is Disrupted by Propofol but Preserved Under Equipotent Doses of Isoflurane. Frontiers in Systems Neuroscience 13, MAY 2019 Notes: eCollection; https://doi.org/10.3389/fnsys.2019.00019.

Proekt A: Emergence Delirium: A New Hypothesis for an Old Problem. Perioperative Neurocognitive Disorders. Eckenhoff RG, Terrando N (eds.). Cambridge University Press, New York NY, Page: 1-8, MAR 2019 Notes: Chapter 1.

Alonso LM, Solovey G, Yanagawa T, Proekt A, Cecchi GA, Magnasco MO: Single-trial classification of awareness state during anesthesia by measuring critical dynamics of global brain activity. Scientific Reports 9(1), MAR 2019.

Proekt A, Hudson AE: A stochastic basis for neural inertia in emergence from general anaesthesia. British Journal of Anaesthesia 121(1): 86-94, JUL 2018.

Shortal BP, Reitz SL, Aggarwal A, Meng QC, McKinstry-Wu AR, Kelz MB, Proekt A: Development and validation of brain target controlled infusion of propofol in mice. PLOS One 13(4), APR 2018 Notes: eCollection; https://doi.org/10.1371/journal.pone.0194949.

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Last updated: 09/28/2020
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