Faculty

Xuyu Qian, PhD

Assistant Professor of Pediatrics (Neurology)

Department: Pediatrics

Graduate Group Affiliations

Neuroscience

Contact information

3615 Civic Center Blvd, ARC502E
Philadelphia, PA 19104

Office: 5083733500

Email:
qianx@chop.edu

Publications

Search PubMed for articles

Education:
B.S. (Biomedical Engineering)
Worcester Polytechnic Institute, 2013.
Ph.D. (Biomedical Engineering)
Johns Hopkins University School of Medicine, 2020.

Links
Search PubMed for articles
Google scholar profile
Qian Lab at BRIDGE Center
Faculty Profile at CHOP

Permanent link

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Description of Research Expertise

Dr. Xuyu Qian's research focuses on understanding the development and diseases of the human cerebral cortex using human-centric approaches. Dr. Qian pioneered the development of human pluripotent stem cell-derived brain organoids and their application as disease models. Dr. Qian also utilizes single-cell spatial transcriptomics to analyze the developing human cortex, uncovering fundamental insights into the formation and specification of distinct cortical layers and areas. By integrating organoid models, spatial omics, and human genetics, Dr. Qian aims to decode healthy developmental programs and identify the genetic and cellular disruptions that lead to diseases, paving the way for advanced therapeutic strategies.

Selected Publications

Qian X, Coleman K, Jiang S, Kriz AJ, Marciano JH, Luo C, Cai C, Manam MD, Caglayan E, Lai A, Exposito-Alonso D, Otani A, Ghosh U, Shao DD, Andersen RE, Neil JE, Johnson R, LeFevre A, Hecht JL, Micali N, Sestan N, Rakic P, Miller MB, Sun L, Stringer C, Li M, Walsh CA.: Spatial transcriptomics reveals human cortical layer and area specification. Nature 2025.

Qian X, Nguyen HN, Song MM, Hadiono C, Ogden SC, Hammack C, Yao B, Hamersky GR, Jacob F, Zhong C, Yoon KJ, Jeang W, Lin L, Li Y, Thakor J, Berg DA, Zhang C, Kang E, Chickering M, Nauen D, Ho CY, Wen Z, Christian KM, Shi PY, Maher BJ, Wu H, Jin P, Tang H, Song H, Ming GL.: Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure. Cell 165(5): 1238-1254, May 2016.

Qian X, DeGennaro EM, Talukdar M, Akula SK, Lai A, Shao DD, Gonzalez D, Marciano JH, Smith RS, Hylton NK, Yang E, Bazan JF, Barrett L, Yeh RC, Hill RS, Beck SG, Otani A, Angad J, Mitani T, Posey JE, Pehlivan D, Calame D, Aydin H, Yesilbas O, Parks KC, Argilli E, England E, Im K, Taranath A, Scott HS, Barnett CP, Arts P, Sherr EH, Lupski JR, Walsh CA.: Loss of non-motor kinesin KIF26A causes congenital brain malformations via dysregulated neuronal migration and axonal growth as well as apoptosis. Dev Cell 57(20): 2381-2396, Oct 2022.

Qian X, Su Y, Adam CD, Deutschmann AU, Pather SR, Goldberg EM, Su K, Li S, Lu L, Jacob F, Nguyen PTT, Huh S, Hoke A, Swinford-Jackson SE, Wen Z, Gu X, Pierce RC, Wu H, Briand LA, Chen HI, Wolf JA, Song H, Ming GL.: Sliced Human Cortical Organoids for Modeling Distinct Cortical Layer Formation. Cell Stem Cell 26(5): 766-781, May 2020.

Qian X, Jacob F, Song MM, Nguyen HN, Song H, Ming GL.: Generation of human brain region-specific organoids using a miniaturized spinning bioreactor. Nat Protoc 13(3): 565-580, Mar 2018.

Tang H, Hammack C, Ogden SC, Wen Z, Qian X, Li Y, Yao B, Shin J, Zhang F, Lee EM, Christian KM, Didier RA, Jin P, Song H, Ming GL.: Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth. Cell Stem Cell 18(5): 587-90, May 2016.

Qian X, Song H, Ming GL.: Brain organoids: advances, applications and challenges. Development 146(8): dev166074, Apr 2019.

Girskis KM, Stergachis AB, DeGennaro EM, Doan RN, Qian X, Johnson MB, Wang PP, Sejourne GM, Nagy MA, Pollina EA, Sousa AMM, Shin T, Kenny CJ, Scotellaro JL, Debo BM, Gonzalez DM, Rento LM, Yeh RC, Song JHT, Beaudin M, Fan J, Kharchenko PV, Sestan N, Greenberg ME, Walsh CA.: Rewiring of human neurodevelopmental gene regulatory programs by human accelerated regions. Neuron 109(20): 3239-3251, Oct 2021.

Jacob F, Salinas RD, Zhang DY, Nguyen PTT, Schnoll JG, Wong SZH, Thokala R, Sheikh S, Saxena D, Prokop S, Liu DA, Qian X, Petrov D, Lucas T, Chen HI, Dorsey JF, Christian KM, Binder ZA, Nasrallah M, Brem S, O'Rourke DM, Ming GL, Song H.: A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity. Cell 180(1): 188-204, Jan 2020.

Coleman K, Schroeder A, Loth M, Zhang D, Park JH, Sung JY, Blank N, Cowan AJ, Qian X, Chen J, Jiang J, Yan H, Samarah LZ, Clemenceau JR, Jang I, Kim M, Barnfather I, Rabinowitz JD, Deng Y, Lee EB, Lazar A, Gao J, Furth EE, Hwang TH, Wang L, Thaiss CA, Hu J, Li M.: Resolving tissue complexity by multimodal spatial omics modeling with MISO. Nat Methods 22(3): 530-538, Mar 2025.