Faculty

Akhilesh Basi Reddy, MA MB BChir PhD

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Associate Professor of Pharmacology
Department: Systems Pharmacology and Translational Therapeutics

Contact information
10-125 Smilow Center for Translational Research
Philadelphia, PA 19104
Education:
BA (Medical Sciences Tripos)
University of Cambridge, UK, 1998.
MB BChir
University of Cambridge, UK, 2003.
PhD
MRC Laboratory of Molecular Biology, Cambridge, UK, 2003.
MA
University of Cambridge, UK, 2012.
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Description of Research Expertise

Circadian clocks, Sleep, Metabolism, Neural circuits, Deep Learning, Machine Intelligence, Large language models (LLMs), AI safety

Selected Publications

O'Neill, J. S. and A. B. Reddy*: Circadian clocks in human red blood cells. Nature 469(7331): 498-503, 2011 Notes: *Senior author. Also covered by News & Views editorial by Bass & Takehashi in the same issue, Nature 469:476–478 (2011).

O'Neill, J. S., G. van Ooijen, L. E. Dixon, C. Troein, F. Corellou, F. Y. Bouget, A. B. Reddy* and A. J. Millar*: Circadian rhythms persist without transcription in a eukaryote. Nature 469(7331): 554-558, 2011 Notes: *Joint senior author. My lab performed the molecular biology aspects.

Edgar RS, Green EW, Zhao Y, van Ooijen G, Olmedo M, Qin X, Xu Y, Pan M, Valekunja UK, Feeney KA, Maywood ES, Hastings MH, Baliga NS, Merrow M, Millar AJ, Johnson CH, Kyriacou CP, O’Neill JS, Reddy AB*.: Peroxiredoxins are conserved markers of circadian rhythms. Nature 485(7399): 459-64, 2012 Notes: *Senior author.

Edgar RS, Stangherlin A, Nagy AD, Nicoll MP, Efstathiou S, O'Neill JS, Reddy AB.: Cell autonomous regulation of herpes and influenza virus infection by the circadian clock. Proc Natl Acad Sci USA 113(36): 10085-90, 2016.

Rey G, Valekunja UK, Feeney KA, Wulund L, Milev NB, Stangherlin A, Ansel-Bollepalli L, Velagapudi V, O’Neill JS, Reddy AB*.: The pentose phosphate pathway regulates the circadian clock. Cell Metabolism 24(3): 462-73, 2016.

Henslee EA, Crosby P, Kitcatt SJ, Parry JSW, Bernardini A, Abdallat RG, Braun G, Fatoyinbo HO, Harrison EJ, Edgar RS, Hoettges KF, Reddy AB, Jabr RI, von Schantz M, O'Neill JS, Labeed FH.: Rhythmic potassium transport regulates the circadian clock in human red blood cells. Nature Communications 8(1): 1978, 2017 Notes: Provided funding, experimental design input and reagents.

Sandipan Ray*, Utham K. Valekunja*, Alessandra Stangherlin, Steven A. Howell, Ambrosius P. Snijders, Gopinath Damodaran, Akhilesh B. Reddy: Circadian rhythms in the absence of the clock gene Bmal1. Science 367(6479): 800-806, 2020.

Ratnasekhar Ch, Guillaume Rey, Sandipan Ray, Pawan K. Jha, Paul C. Driscoll, Mariana Silva Dos Santos, Dania M. Malik, Radoslaw Lach, Aalim M. Weljie, James I. MacRae, Utham K. Valekunja, and Akhilesh B. Reddy: Rhythmic glucose metabolism regulates the redox circadian clockwork in human red blood cells Nature Communications 12(1), 2021.

Pawan K Jha, Utham K Valekunja, Sandipan Ray, Mathieu Nollet, Akhilesh B Reddy : Single-cell transcriptomics and cell-specific proteomics reveals molecular signatures of sleep. Communications Biology 5(1): 846, 2022.

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Last updated: 07/16/2024
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