Akhilesh B. Reddy, MA MB BChir PhD FRCP

faculty photo
Associate Professor of Pharmacology
Department: Pharmacology

Contact information
10-125 Smilow Center for Translational Research
Philadelphia, PA 19104
BA (Medical Sciences Tripos)
University of Cambridge (Downing College), 1998.
PhD (Molecular Neurobiology)
MRC Laboratory of Molecular Biology, Cambridge, 2003.
MB BChir (MB/PhD Programme)
University of Cambridge, 2003.
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Description of Research Expertise

Circadian clocks, Sleep, Metabolism, Neural circuits, Deep Learning

Selected Publications

O'Neill, J. S. and A. B. Reddy*: Circadian clocks in human red blood cells. Nature 469(7331): 498-503, 2011.

O'Neill, J. S., G. van Ooijen, L. E. Dixon, C. Troein, F. Corellou, F. Y. Bouget, A. B. Reddy* and A. J. Millar*: Circadian rhythms persist without transcription in a eukaryote. Nature 469(7331): 554-558, 2011.

Olmedo M, O'Neill JS, Edgar RS, Valekunja UK, Reddy AB, Merrow M.: Circadian regulation of olfaction and an evolutionarily conserved, nontranscriptional marker in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 109(50): 20479-84, 2012.

Edgar RS, Green EW, Zhao Y, van Ooijen G, Olmedo M, Qin X, Xu Y, Pan M, Valekunja UK, Feeney KA, Maywood ES, Hastings MH, Baliga NS, Merrow M, Millar AJ, Johnson CH, Kyriacou CP, O’Neill JS, Reddy AB*.: Peroxiredoxins are conserved markers of circadian rhythms. Nature 485(7399): 459-64, 2012.

Rey G, Valekunja UK, Feeney KA, Wulund L, Milev NB, Stangherlin A, Ansel-Bollepalli L, Velagapudi V, O’Neill JS, Reddy AB*.: The pentose phosphate pathway regulates the circadian clock. Cell Metabolism 24(3): 462-73, 2016.

Edgar RS, Stangherlin A, Nagy AD, Nicoll MP, Efstathiou S, O'Neill JS, Reddy AB.: Cell autonomous regulation of herpes and influenza virus infection by the circadian clock. Proc Natl Acad Sci U S A. 113(36): 10085-90, 2016.

Henslee EA, Crosby P, Kitcatt SJ, Parry JSW, Bernardini A, Abdallat RG, Braun G, Fatoyinbo HO, Harrison EJ, Edgar RS, Hoettges KF, Reddy AB, Jabr RI, von Schantz M, O'Neill JS, Labeed FH.: Rhythmic potassium transport regulates the circadian clock in human red blood cells. Nat Commun. 8(1): 1978, 2017.

Rey G, Milev NB, Valekunja UK, Ch R, Ray S, Silva Dos Santos M, Nagy AD, Antrobus R, MacRae JI, Reddy AB: Metabolic oscillations on the circadian time scale in Drosophila cells lacking clock genes. Molecular Systems Biology 14: e8376, 2018.

Ray S, Lach R, Heesom KJ, Valekunja UK, Encheva V, Snijders AP, Reddy AB: Phenotypic proteomic profiling identifies a landscape of targets for circadian clock-modulating compounds. Life Science Alliance Page: Dec 2;2(6):e201900603, 2019.

Sandipan Ray*, Utham K. Valekunja*, Alessandra Stangherlin, Steven A. Howell, Ambrosius P. Snijders, Gopinath Damodaran, Akhilesh B. Reddy: Circadian rhythms in the absence of the clock gene Bmal1. Science 367(6479): 800-806, 2020.

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Last updated: 06/10/2021
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