Corinde E. Wiers, Ph.D.

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Assistant Professor of Psychiatry
Department: Psychiatry
Graduate Group Affiliations

Contact information
3535 Market Street, Suite 500
Philadelphia, PA 19104
Office: (215)746-1898
Fax: (215)746-7363
B.Sc. (Psychobiology)
University of Amsterdam, 2008.
M.Sc. (Psychology)
University of Amsterdam, 2010.
Ph.D. (Psychology )
Freie Universität Berlin, 2014.
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Description of Research Expertise

The Wiers Lab at Penn focuses on cognitive and neurobiological processes involved in alcohol use disorder (AUD) using PET and MRI neuroimaging. We currently investigate the effects of metabolic ketosis on brain energetics and alcohol consumption in AUD (funded by an NIH K99/R00 Pathway to Independence and NARSAD Young investigator grant).

We are a newly formed group and are recruiting motivated students and postdocs. Please contact us if interested!

Selected Publications

Wiers CE*, Vendruscolo L*, van der Veen JW, Manza P, Shokri-Kojori E, Kroll D, Feldman D, McPherson K, Biesecker E, Zhang R, Herman K, Elvig SK, Vendruscolo JCM, Turner SA, Yang S, Schwandt M, Tomasi D, Cervenka MC, Fink-Jensen A, Benveniste H, Diazgranados N, Wang GJ, Koob GF, Volkow ND: Ketogenic diet reduces alcohol withdrawal symptoms in humans and alcohol intake in rodents. Science Advances 7(15): eabf6780, Apr 2021.

Wiers CE, Martins De Carvalho L, Hodgkinson CA, Schwandt M, Kim SW, Diazgranados N, Wang GJ, Goldman D, Volkow ND: TSPO polymorphism in individuals with alcohol use disorder: Association with cholesterol levels and withdrawal severity. Addiction Biology 26(1): e12838, Jan 2021.

Wiers CE, Cunningham SI, Tomasi DG, Ernst T, Chang L, Shokri-Kojori E, Wang GJ, Volkow ND.: Elevated thalamic glutamate levels and reduced water diffusivity in alcohol use disorder: Association with impulsivity. Psychiatry Res Neuroimaging 305: 111185, Nov 2020.

Kim SW*, Wiers CE*, Tyler R, Shokri-Kojori E, Park L, Zehra A, Freeman C, Ramirez V, Lindgren E, Miller G, Diazgranados N, Pike V, Innis R, Vendruscolo L, Koob G, Tomasi D, Wang GJ, Volkow ND: Influence of alcoholism and cholesterol on TSPO binding in brain: PET [11C]PBR28 studies in humans and rodents. Neuropsychopharmacology 43(9): 1832-39, 2018 Notes: Asterisks indicate shared first authorship.

Wiers CE, Towb PC, Hodgkinson CA, Shen PH, Freeman C, Miller G, Lindgren E, Shokri-Kojori E, Demiral S¸B, Kim SW, Tomasi D, Sun H, Wang GJ, Goldman D, Volkow ND: Association of genetic ancestry with striatal dopamine D2/D3 receptor availability. Molecular Psychiatry 23(8): 1711-16, 2018.

Shokri-Kojori E, Wang GJ, Wiers CE, Demiral S¸B, Guo M, Kim SW, Lindgren E, Ramirez V, Zehra A, Freeman C, Miller G, Manza P, Srivastava T, De Santi S, Tomasi D, Benveniste H, Volkow ND: β-Amyloid accumulation in the human brain after one night of sleep deprivation. PNAS 115(17): 4483-4488, Apr 2018 Notes: doi: 10.1073/pnas.1721694115.

Volkow ND, Wiers CE, Shokri-Kojori E, Tomasi D, Wang GJ, Baler R: Neurochemical and metabolic effects of acute and chronic alcohol in the human brain: studies with positron emission tomography. Neuropharmacology 122: 175-188, Aug 2017 Notes: doi: 10.1016/j.neuropharm.2017.01.012. IF: 5.1.

Wiers CE, Shokri-Kojori E, Wong CT, Abi-Dargham A, Demiral S¸B, Tomasi D, Wang GJ, Volkow ND: Cannabis Abusers show Hypofrontality and Blunted Brain Responses to a Stimulant Challenge in Females but not in Males. Neuropsychopharmacology 41(10): 2596-605, Sep 2016 Notes: doi: 10.1038/npp.2016.67. IF: 7.8.

Wiers CE, Stelzel C, Gladwin T, Park SQ, Pawelczack S, Gawron CK, Stuke H, Heinz A, Wiers RW, Rinck M, Lindenmeyer J, Walter H, Bermpohl F: Effects of cognitive bias modification training on neural alcohol cue reactivity in alcohol-dependence. American Journal of Psychiatry 172(4): 335-43, Apr 2015 Notes: doi: 10.1176/appi.ajp.2014.13111495. IF: 14.7.

Wiers CE, Stelzel C, Park SQ, Gawron CK, Ludwig VU, Gutwinski S, Heinz A, Lindenmeyer J, Wiers RW, Walter H, Bermpohl F: Neural correlates of alcohol-approach bias in alcohol addiction: the spirit is willing but the flesh is weak for spirits. Neuropsychopharmacology 39(3): 688-697, Feb 2014 Notes: doi: 10.1038/npp.2013.252. IF: 7.8.

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Last updated: 11/28/2023
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