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Richard Edmund Phillips, MD PhD
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Presidential Assistant Professor of Neurology
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Department: Neurology
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Contact information
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Hospital of the University of Pennsylvania
1f Department of Neurology
43 3400 Spruce Street, 3 West Gates
Philadelphia, PA 19104
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1f Department of Neurology
43 3400 Spruce Street, 3 West Gates
Philadelphia, PA 19104
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Education:
21 8 BSc 15 (Genetics) c
32 University College London, 2001.
21 8 PhD 17 (Immunology) c
2e King's College London, 2009.
21 7 MD 15 (Medicine) c
2e Kings' College London, 2009.
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Permanent link21 8 BSc 15 (Genetics) c
32 University College London, 2001.
21 8 PhD 17 (Immunology) c
2e King's College London, 2009.
21 7 MD 15 (Medicine) c
2e Kings' College London, 2009.
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273 Dáire Gannon, Eimear Lagan, Ademar Jesus Silva, Peter Bibawi, Anthony M. Doherty, Darragh Nimmo, Rachel McCole, Craig Monger, Giovani Genesi, Aurelie Vanderlinden Dibekeme, James A. Innes, Lu Yang, Bryan Chen, Guido van Mierlo, Pascal W.T.C Jansen, Keiran Wynne, Fran-cisco J. Sánchez-Rivera, Yadira M. Soto-Feliciano, Michiel Vermeulen, Giorgio Oliverio, Chun-Wei Chen, Richard E. Phillips, Adrian P. Bracken, Gerard L. Brien: Specific cPRC1 complexes are co-opted to mediate oncogenic gene repression in diffuse midline glioma. Biorxiv December 2023.
f1 Liang R., Tomita D. Sasaki Y., Ginn J,, Michino M., Huggins D., Baxt L., Kargman S., Shahid M., Kazuyoshi A., Duggan M., Stamford A., DeStanchina E., Liverton N., Meinke P., Foley M., Phillips R.E. 94 : A chemical strategy toward brain penetrant EZH2 inhibitors. ACS Medicinal Chemistry Letters 13(3): 377–387, 2022.
4e Phillips RE, Soshnev AA, Allis CD. 44 : Epigenomic Reprogramming as a Driver of Malignant Glioma. 3a Cancer Cell 38(5): 647-660, 2020.
164 Phillips, R. E., Yang, Y., Smith, R. C., Thompson, B. M., Yamasaki, T., SotoFeliciano, Y. M., Funato, K., Liang, Y., Garcia-Bermudez, J., Wang, X., Garcia, B. A., Yamasaki, K., McDonald, J. G., Birsoy, K., Tabar, V., & Allis, C. D. : Target identification reveals lanosterol synthase as a vulnerability in 55 glioma. Proceedings of the National Academy of Sciences of the United States of 38 America 116(16): 7957–7962, 2019.
bd Phillips, R. E., Curran, K. J., & Khakoo, Y : Management of late extraneural recurrence of medulloblastoma without high-dose chemotherapy. 4b Journal of Neuro-Oncology 124(3): 523–524, 2015.
cf Awosika, O. O., Lyons, J. L., Ciarlini, P., Phillips, R. E., Alfson, E. D., Johnson, E. L., Koo, S., Marty, F., Drew, C., Zaki, S., Folkerth, R. D., & Klein, J. P. 54 : Fatal adenovirus encephalomyeloradiculitis in an umbilical cord stem cell 55 transplant recipient. Neurology 80(18): 1715–1717, 2013.
7d Bartel, G., Brown, K., Phillips, R., Peng, Q., Zhou, W., Sacks, S. H., & Wong, W. 49 : Donor specific transplant tolerance is dependent on complement 51 receptors. Transplant International 26(1): 99-108, 2013.
c3 Wood, B. R., Klein, J. P., Lyons, J. L., Milner, D. A., Phillips, R. E., Schutten, M., Folkerth, R. D., Ciarlini, P., Henrich, T. J., & Johnson, J. A. 60 : HIV-2 encephalitis: Case report and literature review. AIDS Patient Care and STDs 2d 26 (7): 383–387 2012.
e4 Brown, K., Phillips, R. E., & Wong, W : What have we learnt from experimental renal transplantation? Nephron Experimental Nephrology 115(1): e9-e14, 2010.
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Selected Publications
2cb Eimear Lagan, Dáire Gannon, Ademar Jesus Silva, Peter Bibawi, Anthony M Doherty, Darragh Nimmo, Rachel McCole, Craig Monger, Giovani Luiz Genesi, Aurelie Vanderlinden, James A Innes, Charlotte L E Jones, Lu Yang, Bryan Chen, Guido van Mierlo, Pascal W T C Jansen, Chinmayi Pednekar, Alexander Von Kriegsheim, Kieran Wynne, Francisco J Sánchez-Rivera, Yadira M Soto-Feliciano , Angel M Carcaboso, Michiel Vermeulen, Giorgio Oliviero, Chun-Wei Chen, Richard E Phillips*, Adrian P Bracken*, Gerard L Brien*. *=co-corresponding: A specific form of cPRC1 containing CBX4 is co-opted to mediate oncogenic gene repression in diffuse midline glioma. Molecular Cell 31 85(11): 2110-2127, Jun 2025.273 Dáire Gannon, Eimear Lagan, Ademar Jesus Silva, Peter Bibawi, Anthony M. Doherty, Darragh Nimmo, Rachel McCole, Craig Monger, Giovani Genesi, Aurelie Vanderlinden Dibekeme, James A. Innes, Lu Yang, Bryan Chen, Guido van Mierlo, Pascal W.T.C Jansen, Keiran Wynne, Fran-cisco J. Sánchez-Rivera, Yadira M. Soto-Feliciano, Michiel Vermeulen, Giorgio Oliverio, Chun-Wei Chen, Richard E. Phillips, Adrian P. Bracken, Gerard L. Brien: Specific cPRC1 complexes are co-opted to mediate oncogenic gene repression in diffuse midline glioma. Biorxiv December 2023.
f1 Liang R., Tomita D. Sasaki Y., Ginn J,, Michino M., Huggins D., Baxt L., Kargman S., Shahid M., Kazuyoshi A., Duggan M., Stamford A., DeStanchina E., Liverton N., Meinke P., Foley M., Phillips R.E. 94 : A chemical strategy toward brain penetrant EZH2 inhibitors. ACS Medicinal Chemistry Letters 13(3): 377–387, 2022.
4e Phillips RE, Soshnev AA, Allis CD. 44 : Epigenomic Reprogramming as a Driver of Malignant Glioma. 3a Cancer Cell 38(5): 647-660, 2020.
164 Phillips, R. E., Yang, Y., Smith, R. C., Thompson, B. M., Yamasaki, T., SotoFeliciano, Y. M., Funato, K., Liang, Y., Garcia-Bermudez, J., Wang, X., Garcia, B. A., Yamasaki, K., McDonald, J. G., Birsoy, K., Tabar, V., & Allis, C. D. : Target identification reveals lanosterol synthase as a vulnerability in 55 glioma. Proceedings of the National Academy of Sciences of the United States of 38 America 116(16): 7957–7962, 2019.
bd Phillips, R. E., Curran, K. J., & Khakoo, Y : Management of late extraneural recurrence of medulloblastoma without high-dose chemotherapy. 4b Journal of Neuro-Oncology 124(3): 523–524, 2015.
cf Awosika, O. O., Lyons, J. L., Ciarlini, P., Phillips, R. E., Alfson, E. D., Johnson, E. L., Koo, S., Marty, F., Drew, C., Zaki, S., Folkerth, R. D., & Klein, J. P. 54 : Fatal adenovirus encephalomyeloradiculitis in an umbilical cord stem cell 55 transplant recipient. Neurology 80(18): 1715–1717, 2013.
7d Bartel, G., Brown, K., Phillips, R., Peng, Q., Zhou, W., Sacks, S. H., & Wong, W. 49 : Donor specific transplant tolerance is dependent on complement 51 receptors. Transplant International 26(1): 99-108, 2013.
c3 Wood, B. R., Klein, J. P., Lyons, J. L., Milner, D. A., Phillips, R. E., Schutten, M., Folkerth, R. D., Ciarlini, P., Henrich, T. J., & Johnson, J. A. 60 : HIV-2 encephalitis: Case report and literature review. AIDS Patient Care and STDs 2d 26 (7): 383–387 2012.
e4 Brown, K., Phillips, R. E., & Wong, W : What have we learnt from experimental renal transplantation? Nephron Experimental Nephrology 115(1): e9-e14, 2010.
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