Faculty

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Nishant Sinha, Ph.D.

Assistant Professor of Informatics in Biostatistics and Epidemiology at the Hospital of the University of Pennsylvania

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Department: Biostatistics and Epidemiology

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1f Graduate Group Affiliations 8

Neuroscience

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University of Pennsylvania
1f 3600 Civic Center Blvd,
29 5E 309
Philadelphia, PA 19104

Email:
nishant.sinha@pennmedicine.upenn.edu

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18 Publications
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13 Education:
21 b B.Tech 34 ( Electrical and Electronics Engineering) c
39 Sikkim Manipal University, India, 2010.
21 7 MS 2c (Computer Control and Automation) c
44 Nanyang Technological University, Singapore, 2013.
21 8 PhD 3e (Neuroscience, Translational and Clinical Research) c
31 Newcastle University, UK, 2021.
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Links
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Description of Research Expertise

18e I am a neuroscientist with expertise in engineering, informatics, biostatistics, and neurology, specializing in translational and clinical research. The mission of my research program is to develop translational methods that quantify disease severity, progression, and outcomes; remove barriers to clinical translation; and guide personalized treatments for neurological disorders.
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11c My research focuses on three core areas: (1) discover novel methods to integrate multimodal data, (2) develop scalable tools that generalize across multiple sites, and (3) deploy translational products for rigorous retrospective and prospective validation in clinical trials.
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292 To achieve these goals, I develop methods and analytical approaches to process multimodal neural data at scale with four objectives: (a) to develop better therapies through quantitative biomarkers; (b) to understand the natural history of human disease for patient classification, outcome prediction, and treatment selection; (c) to advance understanding of brain networks by integrating multimodal data to bring new insights into both basic and translational neuroscience; and (d) to build a neural-data ecosystem at Penn and expand this initiative nationally and internationally to foster collaboration, data sharing, and innovation in neuroscience.
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Selected Publications

116 Sinha N, Lucas A, Adamiak Davis K.: From data to decision: Scaling artificial intelligence with informatics for epilepsy management. Clin Transl Med 14(12): e70108, Dec 2024 Notes: doi: 10.1002/ctm2.70108.

206 *Gallagher RS, *Sinha N, Pattnaik AR, Ojemann WKS, Lucas A, LaRocque JJ, Bernabei JM, Greenblatt AS, Sweeney EM, Cajigas I, Chen HI, Davis KA, Conrad EC, Litt B.: The sixth sense: how much does interictal intracranial EEG add to determining the focality of epileptic networks? Brain Commun 6(5): fcae320, Sept 2024 Notes: *Co-first and corresponding author: This work was featured in: Quantifying epileptic networks: every data point brings us a step closer to an 4c optimized surgery, Brain Communications, PMID: 39440298.

199 Lucas A, Scheid BH, Pattnaik AR, Gallagher R, Mojena M, Tranquille A, Prager B, Gleichgerrcht E, Gong R, Litt B, Davis KA, Das S, Stein JM, Sinha N.: iEEG-recon: A fast and scalable pipeline for accurate reconstruction of intracranial electrodes and implantable devices. Epilepsia 65(3): 817-829, Mar 2024 Notes: doi: 10.1111/epi.17863.

18d Sinha N, Duncan JS, Diehl B, Chowdhury FA, de Tisi J, Miserocchi A, McEvoy AW, Davis KA, Vos SB, Winston GP, Wang Y, Taylor PN.: Intracranial EEG Structure-Function Coupling and Seizure Outcomes After Epilepsy Surgery. Neurology 101(13): e1293-e1306, Sept 2023 Notes: Editor’s pick, featured as the cover art in Neurology.

17f *Gugger JJ, *Sinha N, Huang Y, Walter AE, Lynch C, Kalyani P, Smyk N, Sandsmark D, Diaz-Arrastia R, Davis KA.: Structural brain network deviations predict recovery after traumatic brain injury. Neuroimage Clinical 38: 103392, Mar 2023 Notes: *Co-first and corresponding author; doi: 10.1016/j.nicl.2023.103392

f4 Sinha N, Johnson GW, Davis KA, Englot DJ.: Integrating Network Neuroscience Into Epilepsy Care: Progress, Barriers, and Next Steps. Epilepsy Curr 22(5): 272-278, May 2022.

17d *Bernabei JM, *Sinha N, Arnold TC, Conrad E, Ong I, Pattnaik AR, Stein JM, Shinohara RT, Lucas TH, Bassett DS, Davis KA, Litt B.: Normative intracranial EEG maps epileptogenic tissues in focal epilepsy. Brain 145(6): 1949-1961, June 2022 Notes: *Co-first and corresponding author; doi: 10.1093/brain/awab480.

1ac Sinha N, Peternell N, Schroeder GM, de Tisi J, Vos SB, Winston GP, Duncan JS, Wang Y, Taylor PN.: Focal to bilateral tonic-clonic seizures are associated with widespread network abnormality in temporal lobe epilepsy. Epilepsia 62(3): 729-741, Mar 2021 Notes: Highlighted by: Editor’s pick, featured as the cover art in Epilepsia; doi: 10.1111/epi.16819.

256 Sinha N, Wang Y, Moreira da Silva N, Miserocchi A, McEvoy AW, de Tisi J, Vos SB, Winston GP, Duncan JS, Taylor PN.: Structural Brain Network Abnormalities and the Probability of Seizure Recurrence After Epilepsy Surgery. Neurology 96(5): e758-e771, Feb 2021 Notes: Featured in: (1) Disentangling the Gordian Knot of Drug-Resistant Epilepsy, Epilepsy Currents, PMID: 34924823 and (2) Network Analyses in Epilepsy Are Nodes and Edges Ready for Clinical Translation?, Neurology PMID: 33361264; doi: 10.1212/WNL.0000000000011315

1ea Sinha N, Dauwels J, Kaiser M, Cash SS, Brandon Westover M, Wang Y, Taylor PN.: Predicting neurosurgical outcomes in focal epilepsy patients using computational modelling. Brain 140: 319-332, Dec 2016 Notes: Featured in: (1) Epileptic Networks & Surgery—Epilepsy Curr. PMID 28684949; (2) Virtual Resections & Outcomes—Neurosurgery. PMID 28859458; (3) Computational Modelling in Localization—Brain. PMID 28137953.

183 Goldblum, Z., Xu, Z., Shi, H., Orzechowski, P., Spence, J., Davis, K.A., Litt, B., Sinha, N. and Wagenaar, J: Pennsieve: a collaborative platform for translational neuroscience and beyond. Scientific Data. Nature Publishing Group (Springer Nature), Page: 1834, November 2025 Notes: doi: 10.1038/s41597-025-06075-5.

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