Ellen Puré, Ph.D

faculty photo
Professor of Pharmacology
Department: Pharmacology
Graduate Group Affiliations

Contact information
Department of Biomedical Sciences
3800 Spruce Street
216E Vet
Philadelphia, PA 19104
Office: (215) 573-9406
Fax: (215) 573-6810
Lab: (215) 573-9405
Education:
A.B. (Biology)
Washington University, 1977.
Ph.D. (Immunology)
UT Southwestern Medical School, 1981.
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Description of Research Expertise

Tumor Microenvironment
Cellular and molecular basis of inflammation and fibrosis

Key words: inflammation, fibrosis, extracellular matrix, mouse genetics, ageing, dynamic macromolecular complexes, cell polarity, alternative splicing

This laboratory is studying the cellular and molecular basis of inflammation and fibrosis, with a particular focus on the role of stromal cells and extracellular matrix (ECM), in the context of chronic inflammatory diseases and cancer. The molecular pathways currently being studied include the adhesion receptor CD44 and its principle ligand, hyaluronan, and fibroblast activation protein (FAP), a stromal cell surface protease. Studies of CD44 and FAP are being conducted in mouse models of cancer, cardiovascular disease and pulmonary fibrosis using conditional CD44 knockout mice and FAP-null mice generated in the lab. Also the FAP promoter has been exploited to generate mice that can be used to non-invasively image reactive stromal cells in fibrotic lesions and epithelial-derived tumors, to conditionally ablate reactive stromal cells, and to manipulate gene expression specifically in fibrotic lesions and tumor stromal cells. We are studying the impact of matrix modification on cell behavior directly through regulation of receptor mediated signal transduction as well as through modulation of tissue stiffness. We are also exploring the function of CD44 and FAP in human disease.

Selected Publications

Bell Brett I, Koduri Sravya, Salas Salinas Carlo, Monslow James, Puré Ellen, Ben-Josef Edgar, Koumenis Constantinos, Verginadis Ioannis I: Interleukin 6 Signaling Blockade Exacerbates Acute and Late Injury From Focal Intestinal Irradiation. International journal of radiation oncology, biology, physics 103(3): 719-727, Mar 2019.

Liu Shu-Lin, Bajpai Anamika, Hawthorne Elizabeth A, Bae Yongho, Castagnino Paola, Monslow James, Puré Ellen, Spiller Kara L, Assoian Richard K: Cardiovascular protection in females linked to estrogen-dependent inhibition of arterial stiffening and macrophage MMP12. JCI insight 4(1), Jan 2019.

Govindaraju Priya, Todd Leslie, Shetye Snehal, Monslow James, Puré Ellen: CD44-dependent inflammation, fibrogenesis, and collagenolysis regulates extracellular matrix remodeling and tensile strength during cutaneous wound healing. Matrix biology : journal of the International Society for Matrix Biology 75-76: 314-330, 01 2019.

Puré Ellen: Seeking Synergy of Checkpoint Blockade through TGFβ Inhibition. Cancer immunology research 6(12): 1444, Dec 2018.

Cremasco Viviana, Astarita Jillian L, Grauel Angelo L, Keerthivasan Shilpa, MacIsaac Kenzie, Woodruff Matthew C, Wu Michael, Spel Lotte, Santoro Stephen, Amoozgar Zohreh, Laszewski Tyler, Migoni Sara Cruz, Knoblich Konstantin, Fletcher Anne L, LaFleur Martin, Wucherpfennig Kai W, Pure Ellen, Dranoff Glenn, Carroll Michael C, Turley Shannon J: FAP Delineates Heterogeneous and Functionally Divergent Stromal Cells in Immune-Excluded Breast Tumors. Cancer immunology research 6(12): 1472-1485, Dec 2018.

Krolikoski Mia, Monslow James, Puré Ellen: The CD44-HA axis and inflammation in atherosclerosis: A temporal perspective. Matrix biology : journal of the International Society for Matrix Biology May 2018.

Raposo-Ferreira Talita M M, Brisson Becky K, Durham Amy C, Laufer-Amorim Renee, Kristiansen Veronica, Puré Ellen, Volk Susan W, Sorenmo Karin: Characteristics of the Epithelial-Mesenchymal Transition in Primary and Paired Metastatic Canine Mammary Carcinomas. Veterinary pathology 55(5): 622-633, 09 2018.

Avery Diana, Govindaraju Priya, Jacob Michele, Todd Leslie, Monslow James, Puré Ellen: Extracellular matrix directs phenotypic heterogeneity of activated fibroblasts. Matrix biology : journal of the International Society for Matrix Biology 67: 90-106, 04 2018.

Puré Ellen, Hingorani Sunil R: Mesenchymal Cell Plasticity and Perfidy in Epithelial Malignancy. Trends in cancer 4(4): 273-277, 04 2018.

Puré Ellen, Blomberg Rachel: Pro-tumorigenic roles of fibroblast activation protein in cancer: back to the basics. Oncogene 37(32): 4343-4357, 08 2018.

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Last updated: 01/08/2018
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