Faculty

Huafeng Wei, MD, PhD

Professor of Anesthesiology and Critical Care

Department: Anesthesiology and Critical Care

Graduate Group Affiliations

Pharmacology

Contact information

Department of Anesthesiology and Critical Care Medicine
University of Pennsylvania
305 John Morgan Building
3620 Hamilton Walk
Email: huafeng.wei@pennmedicine.upenn.edu
Philadelphia, PA 19104-6112

Office: 215-260-9840
Fax: 215-349-5078
Lab: 215-5738230

Email:
huafeng.wei@pennmedicine.upenn.edu

Publications

Search PubMed for articles

Education:
Diploma (Medicine)
Jining Medical School, Jining, China, 1982.
MD (Medicine)
Tongji Medical University, Wuhan, China, 1988.
PhD (Pharmacology and Toxicology)
George Washington University, Washington, DC, 1996.

Links
Search PubMed for articles
Huafeng Wei Website

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Research Expertise

Basic science: Role of intracellular calcium dysregulation on neuronal apoptosis and neurodegeneration, autophagy, synapse, cognitive dysfunction, depression and anxiety psychiatric disorders, in neurodegenerative diseases, especially in Alzheimer's Disease, stroke, and amyotrophic lateral sclerosis. Treatment of Alzheimer's disease. Mechanisms of anesthesia mediated dual effects of neuroprotection and neurotoxicity, especially in the developing brains and in Alzheimer's disease.

Clinical science: Clinical use of Supraglottic Jet Oxygenation and Ventilation (SJOV) to maintain oxygenation/ventilation in patients with respiratory depression or apnea, especially during difficult airway management, emergent airway management rescue.

Description of Clinical Expertise

General practice of anesthesia, Difficult airway management, Clinical use of Supraglottic Jet Oxygenation and Ventilation (SJOV)

Description of Other Expertise

Taichi (one type of Chinese Kungfu Master. Total six gold medals, five silver medals and two brown model on various international Wushu (Kungfu) competitions.

Selected Publications

Piplu Bhuiyan, Wenjia Zhang, Rebecca Chae, Kyulee Kim, Lauren St. Louis, Ying Wang, Ge Liang, Huafeng Wei: Intranasal dantrolene nanoparticles inhibit inflammatory pyroptosis in 5xFAD mice brains. British Journal of Anaesthesia 134(5): 1574-1577, April 2025 Notes: DOI: 10.1016/j.bja.2025.02.018

Piplu Bhuiyan, Wenjia Zhang, Ge Liang, Bailin Jiang, Robert Vera, Rebecca Chae, Kyulee Kim, Lauren St. Louis, Ying Wang, Jia Liu, De-Maw Chuang, Huafeng Wei: Intranasal Delivery of Lithium Salt Suppresses Inflammatory Pyroptosis in the brain and Ameliorates Memory Loss and Depression-like Behavior in 5xFAD mice. Journal of Neuroimmune Pharmacology 20: 26, Mar 2025 Notes: 2025 Mar 17;20(1):26. PMID: 40095208, PMCID: PMC11914297. doi: 10.1007/s11481-025-10185-7.

Yang M, Li H, Zhou Y, Wei H, Cheng Q.: Type and morphology affect the success rate of bronchoscopy for postintubation tracheal stenosis. Laryngoscope Investig Otolaryngol 9: e70002, Aug 2024.

Xu R, Li Z, Jiang X, Zhang W, Xu Y, Zhang Y, Zhu L, Wei H, Shi H, Wang X.: Effect of supraglottic jet oxygenation and ventilation on hypoxemia in patients undergoing endoscopic surgery with sedation: A meta-analysis of randomized controlled trials. J Clin Anesth 97: 111559, Jul 2024.

Frank R. Chen, Kara R. Yao, Joshua Atkins, Huafeng Wei: Supraglottic Jet Oxygenation and Ventilation (SJOV) to Assist Emergent Resection of a Large Vocal Cord Tumor Using Suspension Laryngoscopy. Annals of Otolaryngology Head and Neck Surgery (AOHNS) 3: 1-3, 2024.

Vera R, Hong N, Jiang B, Liang G, Eckenhoff MF, Kincaid HJ, Browne V, Chellaraj V, Gisewhite D, Greenberg M, Ranjan S, Zhu G, Wei H.: Effects of Intranasal Dantrolene Nanoparticles on Brain Concentration and Behavior in PS19 Tau Transgenic Mice. J Alzheimers Dis 2024.

Yang M, Li H, Zhou Y, Li H, Wei H, Cheng Q.: Airway collapse hinders recovery in bronchoscopy therapy for postintubation tracheal stenosis patients. Eur Arch Otorhinolaryngol 2024.

Ping Xie, Zhiyun Wu, Benjun Zha1, Li Xu, Shanyi Shen, Haibin Zhuang, Huafeng Wei: Risk factors for pharyngalgia and xerostomia undergoing supraglottic jet oxygenation and ventilation in gastrointestinal endoscopy: A retrospective study Scientific Report. Accepted Manuscript, Dec 2023.

Mingyuan Yang, Yunzhi Zhou, Hong Li, Huafeng Wei, Qinghao Cheng: Lung isolation—a personalized and clinically adapted approach to control bronchoscopy-associated acute massive airway hemorrhage. BMC Pulmonary Medicine. PMID: 38037018 PMCID: PMC10691002 DOI: 10.1186/s12890-023-02780-2, 23: 1-9, Nov 2023.

Yang M, Wei H, Hou Q, Wang B, Cheng Q: Evaluation of Supraglottic Jet Oxygenation and Ventilation in 105 Patients During Bronchoscopy Using the Twinstream® Microprocessor-Controlled Jet Ventilator and the Wei Nasal Jet® Tube. Medical Science Monitor. doi: 10.12659/MSM.938602, 29: e938602, Jan 2023.