Faculty

Mark Anthony Sellmyer, MD, PhD

Assistant Professor of Radiology

Department: Radiology

Graduate Group Affiliations

Contact information

University of Pennsylvania
Perelman School of Medicine
Department of Radiology
3400 Spruce St., 1 Silverstein, Ste. 130
Philadelphia, PA 19104

Office: 617-543-6546
Lab: 215-573-3212

Publications

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Education:
BS (Chemistry)
Massachusetts Institute of Technology , 2004.
MD
Stanford Medical School, 2012.
PhD (Chemical and Systems Biology)
Stanford Medical School, 2012.

Links
Search PubMed for articles
Sellmyer Lab Webpage
Sellmyer Lab Twitter Feed
Codirector of the Center for Translational Chemical Biology

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Clinical Expertise

Nuclear Radiology
Cancer Imaging and Therapy
Infection and Inflammation

Description of Research Expertise

Molecular Imaging
Chemical Biology
Synthetic Biology
Radiology
Nuclear Imaging and Therapy

Selected Publications

Lee, I. K., Sharma, N., Noguera-Ortega, E., Liousia, M., Baroja, M. L., Etersque, J. M., Pham, J., Sarkar, S., Carreno, B. M., Linette, G. P., Pure, E., Albelda, S. M., Sellmyer, M. A.: A genetically encoded protein tag for control and quantitative imaging of CAR T cell therapy. Mol Ther 31(12): 3564-3578, Nov 2023.

Etersque, J. M., Lee, I. K., Sharma, N., Xu, K., Ruff, A., Northrup, J. D., Sarkar, S., Nguyen, T., Lauman, R., Burslem, G. M., Sellmyer, M. A.: Regulation of eDHFR-tagged proteins with trimethoprim PROTACs. Nat Commun 14(1): 7071, Nov 2023.

Lee IK, Noguera-Ortega E, Xiao Z, Todd L, Scholler J, Song D, Liousia M, Lohith K, Xu K, Edwards KJ, Farwell MD, June CH, Albelda SM, Puré E, Sellmyer MA: Monitoring Therapeutic Response to Anti-FAP CAR T Cells Using [18F]AlF-FAPI-74. Clin Cancer Res 28(24): 5330-5342, Dec 2022.

Edwards KJ, Chang B, Babazada H, Lohith K, Park DH, Farwell MD, Sellmyer MA: Using CD69 PET Imaging to Monitor Immunotherapy-Induced Immune Activation. Cancer Immunol Res 10(9): 1084-1094, Sept 2022.

Iris K Lee, Daniel A Jacome, Joshua K Cho, Vincent Tu, Anthony J Young, Tiffany Dominguez, Justin D Northrup, Jean M Etersque, Hsiaoju S Lee, Andrew Ruff, Ouniol Aklilu, Kyle Bittinger, Laurel J Glaser, Daniel Dorgan, Denis Hadjiliadis, Rahul M Kohli, Robert H Mach, David A Mankoff, Robert K Doot, Mark A Sellmyer: Imaging sensitive and drug-resistant bacterial infection with [11C]-trimethoprim. The Journal of Clinical Investigation 132(18): e156679, Mar 2023 Notes: doi: 10.1172/JCI156679.

Mankoff DA, Sellmyer MA: PET of Fibroblast-Activation Protein for Breast Cancer Diagnosis and Staging. Radiology 302(1): 48-49, Jan 2022.

Mark A Sellmyer, Iris K Lee, David A Mankoff: Building the bridge: molecular imaging biomarkers for 21st century cancer therapies. Journal of Nuclear Medicine 62(12): 1672–6, Dec 2021.

Jacome, D. A., Northrup, J. D., Ruff, A. J., Reilly, S. W., Lee, I. K., Blizard, G. S., Sellmyer, M. A.: A Chemical Approach for Programmable Protein Outputs Based on Engineered Cell Interactions. ACS Chem Biol 16(1): 52-57, Jan 2021.

Sellmyer Mark A, Richman Sarah A, Lohith Katheryn, Hou Catherine, Weng Chi-Chang, Mach Robert H, O'Connor Roddy S, Milone Michael C, Farwell Michael D: Imaging CAR T Cell Trafficking with eDHFR as a PET Reporter Gene. Molecular therapy : the journal of the American Society of Gene Therapy 28(1): 42-51, Jan 2020.