Faculty

Jeffrey David Roizen, M.D., Ph.D.

faculty photo
Assistant Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations

Contact information
The Children's Hospital of Philadelphia
3401 Civic Center Blvd.
Division of Endocrinology and Diabetes
11th Floor/NWT/Suite 30
Philadelphia, PA 19104
Office: 215-590-3174
Fax: 215-590-3053
Lab: 267 678 3597
Education:
BA (Chemistry and Biology (double major))
Williams College, Williamstown, MA, 2000.
MD
Washington university School of Medicine, St. Louis, MO, 2008.
PhD (Molecular and Cell Biology)
Washington University School of Medicine, St. Louis, MO, 2008.
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Description of Clinical Expertise

Dr. Roizen is a clinician scientist at the Children’s Hospital of Philadelphia.

His clinical interests include metabolic bone diseases with a focus on vitamin D metabolism, hyperparathyroidism and pseudohypoparathyroidism as well as obesity, type 2 diabetes and type 1 diabetes.

Dr. Roizen collaborates with Dr. Levine and Dr. Hakonarson. Each of whom has an active laboratory research program that complements and extends his clinical studies.

Dr. Roizen has more than 30 papers, patents and chapters.

He is a member of numerous professional societies, including the American Society for Bone and Mineral Research, the Endocrine Society, the Pediatric Endocrine Society and the American Diabetes Association. He is on the Editorial Board of the journal of Clinical Endocrinology and Metabolism (JCEM). He is a Fellow of the American Academy of Pediatrics.

Description of Other Expertise

Dr. Roizen is a 5.0-5.5 level competitive squash player and is a past champion of the St. Louis Open Amateur Draw and past runner up in the Windy City Open Amateur Draw. He is currently ranked in the top 500 nationally in the 5.0 skill group.

Description of Research Expertise

The goal of our laboratory is to understand non-calciometabolic effects of vitamin D and to use this understanding to design new therapeutic approaches to common diseases such as sarcopenia and obesity. Towards this goal we employ a uniquely diverse toolbox of methods using large human data sets and mouse physiology combined with high throughput sequencing to drive questions in cell culture and results from unbiased screening in cell culture to drive test-of-principle experiments and trials in mice and humans. Additionally, we rely on core principles of improv (“LISTEN” (to your collagues and to the data), say “yes, and…” (if you encounter a fact that doesn’t fit your theory, follow the fact), “find the game” (what is interesting, can you set up your Qs so that any answer is interesting), “If this is true, then what else is true…” (if you find something interesting, does it imply other interesting things), “there are no mistakes” (for well designed experiments, there are no failures)) to drive our science.

Selected Publications

Qu J, Qu HQ, Bradfield JP, Glessner JT, Chang X, Tian L, March ME, Roizen JD, Sleiman PM, Hakonarson H.: Association of DLL1 with type 1 diabetes in patients characterized by low polygenic risk score. Metabolism 114: 154418, Jan 2021.

Casella A, Long C, Zhou J, Lai M, O'Lear L, Caplan I, Levine MA, Roizen JD.: Differential Frequency of CYP2R1 Variants Across Populations Reveals Pathway Selection for Vitamin D Homeostasis. J Clin Endocrinol Metab 105: 1302-15, May 2020.

Roizen JD, Asada M, Tong M, Tai HH, Muglia LJ.: Early pregnancy loss in 15-hydroxyprostaglandin dehydrogenase knockout (15-HPGD(-/-)) mice due to requirement for embryo 15-HPGD activity. Sci Rep 9: 17612, Nov 2019.

Roizen JD, Levine MA: Response to: Obesity and Vitamin D Metabolism Modifications. Journal of bone and mineral research 34(7): 1384, Jul 2019.

Roizen JD, Long C, Casella A, O'Lear L, Caplan I, Lai M, Sasson I, Singh R, Makowski AJ, Simmons R, Levine M: Obesity Decreases Hepatic 25-Hydroxylase Activity Causing Low Serum 25-Hydroxyvitamin D. Journal of bone and mineral research 34(6): 1068-1073, Jun 2019.

Pandey Rahul, Bakay Marina, Hain Heather S, Strenkowski Bryan, Elsaqa Barakat Z B, Roizen Jeffrey D, Kushner Jake A, Orange Jordan S, Hakonarson Hakon: CLEC16A regulates splenocyte and NK cell function in part through MEK signaling. PloS one 13(9): e0203952, September 2018.

Roizen Jeffrey D, Casella Alex, Lai Meizan, Long Caela, Tara Zahra, Caplan Ilana, O'Lear Lauren, Levine Michael A: Decreased Serum 25-Hydroxyvitamin D in Aging Male Mice Is Associated With Reduced Hepatic Cyp2r1 Abundance. Endocrinology 159(8): 3083-3089, Aug 2018.

Roizen JD, Li D, O'Lear L, Javaid MK, Shaw NJ, Ebeling PR, Nguyen HH, Rodda CP, Thummel KE, Thacher TD, Hakonarson H, Levine MA.: CYP3A4 mutation causes vitamin D-dependent rickets type 3. Journal of Clinical Investigation 128(5): 1913-1918, May 2018.

Hong J, Hatchell KE, Bradfield JP, Andrew B, Alessandra C, Chao-Qiang L, Langefeld CD, Lu L, Lu Y, Lutsey PL, Musani SK, Nalls MA, Robinson-Cohen C, Roizen JD, Saxena R, Tucker KL, Ziegler JT, Arking DE, Bis JC, Boerwinkle E, Bottinger EP, Bowden DW, Gilsanz V, Houston DK, Kalkwarf HJ, Kelly A, Lappe JM, Liu Y, Michos ED, Oberfield SE, Palmer ND, Rotter JI, Sapkota B, Shepherd JA, Wilson JG, Basu S, de Boer IH, Divers J, Freedman BI, Grant SFA, Hakanarson H, Harris TB, Kestenbaum BR, Kritchevsky SB, Loos RJF, Norris JM, Norwood AF, Ordovas JM, Pankow JS, Psaty BM, Sanhgera DK, Wagenknecht LE, Zemel BS, Meigs J, Dupuis J, Florez JC, Wang T, Liu CT, Engelman CD, Billings LK.: Trans-ethnic Evaluation Identifies Novel Low Frequency Loci Associated with 25-Hydroxyvitamin D Concentrations. J Clin Endocrinol Metab. 103(4): 1380-1392, Apr 2018.

Roizen JD, Palladino A.: Chapter 72: Disorders of the Adrenal Gland. Comprehensive Pediatric Hospital Medicine, Second Edition. Zaoutis L, Chiang VW. (eds.). Page: 336-41, Dec 2017.

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Last updated: 03/01/2021
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