Caroline R Bartman, PhD

faculty photo
Assistant Professor of Pharmacology
Department: Systems Pharmacology and Translational Therapeutics

Contact information
Room 9-136
Smilow Center for Translational Research
3400 Civic Center Blvd
University of Pennsylvania
Philadelphia, PA 19104
AB (Biology; Immunology Specialization)
University of Chicago, 2012.
PhD (Immunology)
University of Pennsylvania, 2018.
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Description of Research Expertise

Research Interests : The goal of the Bartman lab is to use isotope tracing and metabolomics to identify metabolic fluxes that are altered in tumors and immune cells, and to manipulate these fluxes to treat disease.

Keywords: metabolic flux, metabolomics, isotope tracing, cancer, immunology

Research Details: We develop novel experimental, mass spectrometry, and quantitative analysis approaches to measure metabolism in vivo in mice and humans. We will identify metabolic pathways dramatically altered in different tumor types or inflammatory conditions, then manipulate those pathways to halt cancer growth or lessen inflammation.

Rotation Projects: Key projects in the lab include 1) measuring the rate of the glycosylation pathway and how it changes in inflammation and cancer, 2) measuring the metabolism of different immune cell populations in tumors to determine whether they are distinct from tumor cells, 3) engineering the metabolism of CAR-T cells and testing whether this can improve therapeutic efficacy.

Lab Personnel: Tanay Parnaik (research specialist)

Selected Publications

Bartman CR, Weilandt DR, Shen Y, Lee WD, Han Y, TeSlaa T, Jankowski CSR, Samarah L, Park NR, da Silva-Diz V, Aleksandrova M, Gultekin Y, Marishta A, Wang L, Yang L, Roichman A, Bhatt V, Lan T, Hu Z, Xing X, Lu W, Davidson S, Wühr M, Vander Heiden MG, Herranz D, Guo JY, Kang Y, Rabinowitz JD.: Slow TCA flux and ATP production in primary solid tumours but not metastases. Nature February 2023.

Bartman CR, TeSlaa R, Rabinowitz JD: Quantitative flux analysis in mammals. Nature Metabolism 3(7): 896-908, July 2021.

TeSlaa T, Bartman CR, Jankowski C, Zhang Z, Xu X, Xing X, Wang L, Lu W, Hui S, Rabinowitz JD.: The source of glycolytic intermediates in mammalian tissues. Cell Metabolism 33(2): 367-378, January 2021.

Hui S, Cowan AJ, Zeng X, Yang L, TeSlaa T, Li X, Bartman C, Zhang Z, Jang C, Wang L, Lu W, Rojas J, Baur J, Rabinowitz JD.: Quantitative fluxomics of circulating metabolites. Cell Metabolism 32(4): 676-688, August 2020.

Berríos KN, Evitt NH, DeWeerd R, Ren D, Luo M, Barka A, Wang T, Bartman CR, Lan Y, Green AM, Shi J, Kohli RM.: Controllable genome editing with split-engineered base editors. Nature Chemical Biology 17(12): 1262-1270, October 2021.

Bartman CR, Hamagami N, Keller CA, Giardine B, Blobel GA*, Raj A*: Transcriptional burst initiation and polymerase pause release are key control points of transcriptional regulation. Molecular Cell 73(3): 519-532, February 2019.

Bartman CR, Hsu SC, Hsiung CCS, Raj A*, Blobel GA*: Enhancer regulation of transcriptional bursting parameters revealed by forced chromatin looping. Molecular Cell 62(2): 237-247, April 2016.

Lei YM, Chen L, Wang Y, Stefka A, Nair L, Molinero L, Theriault B, Aquino-Michaels K, Sivan A, Nagler C, Chong A, Bartman C*, Alegre ML*: The microbiota modulates skin graft rejection. Journal of Clinical Investigation 126(7): 2736-2744, July 2016.

Pauken KE, Sammons MA, Odorizzi PM, Manne S, Godec J, Khan O, Drake AM, Chen Z, Sen D, Kurachi M, Barnitz RA, Bartman C, Bengsch B, Huang AC, Schenkel JM, Vahedi G, Haining WN, Berger SL, Wherry EJ.: Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade. Science 354(6316): 1160-1165, October 2016.

Hsu SC, Gilgenast TG, Bartman CR, Edwards CR, Stonestrom AJ, Huang P, Emerson DJ, Evans P, Werner MT, Jahn KS, Keller CA, Giardine B, Hardison RC, Raj A, Phillips-Cremins J, Blobel GA.: The BET protein BRD2 cooperates with CTCF to enforce transcriptional and architectural boundaries. Molecular Cell 66(1): 102-116, May 2017.

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Last updated: 10/09/2023
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