Faculty

Norbert Pardi, PhD

Associate Professor of Microbiology

Department: Microbiology

Graduate Group Affiliations

Contact information

476A Stemmler Hall
Philadelphia, PA 19104

Office: 215 746 6552

Email:
pnorbert@pennmedicine.upenn.edu

Education
MSc (Biochemistry and Genetics)
University of Szeged, Hungary, 2004.
PhD (Biochemistry and Genetics)
University of Szeged, Hungary, 2011.

Links
Lab Website

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Research Expertise

mRNA therapeutics

Selected Publications

Nishida J, Seehawer M, Rojas Jimenez E, Yan P, Bui TM, Foidart P, Muramatsu H, Goyette MA, Cai X, Li Z, Beattie MB, Pardi N, Polyak K.: Breast cancer prevention by prophylactic Lalba mRNA-LNP vaccination Proc Natl Acad Sci 123(36): e2621855123, Sep 2026.

Braun RM, Ferretti MB, Lee JS, Miller J, Castellana L, Acuña J, Whig K, Dohnalová L, Descamps HC, Huber AS, Muramatsu H, Hewins P, Li Y, Bhutda S, Etwebi Z, Dittmar M, Cook T, Schultz DC, Blackshear PJ, Jurado KA, Thaiss CA, Pardi N, Lynch KW, Cherry S.: Selective decay of interferon mRNAs controls antiviral immunity and innate memory Mol Cell 86(17): 3565-3584, Sep 2026.

Vadovics M, Pampena MB, Lam K, Lundgreen KA, Muramatsu H, Sárközy A, Ábrahám E, Lipinszki Z, Bates P, Betts MR, Heyes J, Pardi N.*: Evaluation of lipid nanoparticle adjuvants with different PEG lipid ratios and phospholipid modifications in non-human primates Mol Ther Nucleic Acids 37(3): 102999, Jul 2026.

Cody EW, Ningoo M, Monga I, Tsankov AM, Muramatsu H, Pardi N, Fribourg M, Heeger PS, Dominguez-Sola D.: Complement-regulated homeostatic proliferation controls memory B cell longevity and repertoire composition. J Exp Med 223(77): e1014337, Jul 2026.

Hook LM, Cairns TM, Awasthi S, Egan KP, Gopalakrishnan M, Syeda Z, Pardi N, Bergstrom T, Cohen GH, Friedman HM.: HSV-2 gC2 mRNA immunization in mice protects by producing antibodies that bind immune evasion epitopes PLoS Pathog 222(6): e1014337, Jun 2026.

Sturtz AJ, Evavold BK, Heidari Rarani Z, Alsoussi WB, Zhou JQ, Matz HC, Muramatsu H, Simkins W, Kumar Malladi S, McIntire KM, Das J, Turner JS, Pardi N, Ellebedy AH.: BPTF is essential for vaccine-induced germinal center B cell responses J. Immunol 215(6): vkag126, Jun 2026.

Locci M, Pardi N*: Immunological mechanisms of mRNA vaccines for infectious diseases. Nature 8120(654): 892-901, Jun 2026.

Sweileh RBA, Pardi N*: Silencing the alarm: nucleoside modifications suppress innate immune sensing of RNA J Immunol 215(6): 345, Jun 2026.

Tálas A, Ioannidi EI, Weber Y, Haenggi T, Kulcsár PI, Zürcher N, Faccin E, Moon WJ, Kissling L, Villiger EA, Matsushita M, Rothgangl T, Janjuha S, Lin PJC, Poms M, Muramatsu H, Vadovics M, Reichmuth A, Kopf M, Pardi N, Tam YK, Häberle J, Schwank G.: RNA-LNP-mediated in vivo prime editing corrects disease phenotypes in a mouse model of citrullinemia type I Sci Transl Med 18(849): eaec7274, May 2026.

Janjuha S, Haenggi T, Chamberlain TC, Rothgangl T, Kissling L, Wilhelm M, Mathis N, Boeck D, Marquart K, Ioannidi E, Moon WJ, Muramatsu H, Vadovics M, Pardi N, Semple SC, Tam YK, Schwank G.: Spatial profiling of gene editing by in situ sequencing in mice and macaques. Nat Biomed Eng 10(5): 968-979, May 2026.