Melanie Ruffner, MD, PhD

faculty photo
Assistant Professor of Pediatrics (Allergy/Immunology )
Department: Pediatrics
Graduate Group Affiliations

Contact information
Children’s Hospital of Philadelphia
Division of Allergy and Immunology
3615 Civic Center Blvd.
Philadelphia, PA 19104
Office: 2155902549
Fax: 2155906849
Lab: 2155904685
B.S. (Biomedical Engineering)
Johns Hopkins University, 2003.
Ph.D. (Bioengineering)
University of Pittsburgh, 2009.
M.D. (Medicine)
University of Pittsburgh, 2011.
M.S. (Translational Research)
University of Pennsylvania, 2020.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Selected Publications

Spergel BL, Ruffner MA, Godwin BC, Liacouras CA, Cianferoni A, Gober L, Hill DA, Brown-Whitehorn TF, Chaiboonma K, Aceves SA, Muir AM, Spergel JM: Improvement in eosinophilic esophagitis when using dupilumab for other indications or compassionate use. Ann Allergy Asthma Immunol 128(5): 589-593, May 2022.

Ruffner MA, Zhang Z, Maurer K, Muir AB, Cianferoni C, Sullivan KE, Spergel JS: RNA sequencing identifies global transcriptional changes in peripheral CD4 + cells during active oesophagitis and following epicutaneous immunotherapy in eosinophilic oesophagitis. Clin Transl Immunology 10(7): e1314, July 2021.

Benitez AJ, Bittinger K, Tanes C, Hofstaedter CE, Kim DK, Gross J, Ruffner MA, Albenberg L, Spergel JM, Muir AB. : Effect of topical swallowed steroids on the bacterial and fungal esophageal microbiota in eosinophilic esophagitis. Allergy 76(5): 1549-1552, May 2021.

Ruffner MA*, Hu A*, Dilollo J, Benocek K, Shows D, Gluck M, Spergel JM, Ziegler SF, Hill DA, Cerosaletti K. *contributed equally: Conserved interferon signature in adult and pediatric eosinophilic esophagitis. Journal of Immunology 206(6): 1361-1371, Mar 2021.

Chiang AWT, Duong LD, Shoda T, Nhu QM, Ruffner M, Hara T, Aaron B, Joplin E, Manresa M, Abonia JP, Dellon E, Hirano I, Gonsalves N, Gupta S, Furuta G, Rothenberg ME, Lewis NE, Muir AB, Aceves SS; CEGIR Investigator Group.: Type 2 immunity and age modify gene expression of COVID19 receptors in eosinophilic GI disorders. J Pediatr Gastrerol Nutr 72(5): 718-722, May 2021.

Ruffner MA, Song L, Mauer K, Shi L, Wang JX, Muir AB, Spergel JM, Sullivan KE: Toll‐like receptor 2 stimulation augments esophageal barrier integrity Allergy 74(12): 2449-2460, Dec 2019.

Ruffner MA, Wang KY, Dudley JW, Cianferoni A, Grundemeier R, Spergel JM, Brown-Whitehorn TF, Hill DA. : Elevated Allergic Comorbidity in Patients with Food Protein-Induced Enterocolitis. J Allergy Clin Immunol Pract. 8(3): 1039-1046, Mar 2020.

Kennedy K, Muir AB, Grossman A, Brown-Whitehorn T, Cianferoni A, Spergel JM, Furuta GT, Wilkins BJ, Shuker M, Ruffner MA. : Modified oral enteric-coated budesonide regimens to treat pediatric eosinophilic gastroenteritis, a single center experience. J Allergy Clin Immunol Pract. 7(6): 2059-2061, Jul 2019.

Ruffner MA, Brown-Whitehorn TF, Verma R, Cianferoni A, Gober L, Shuker M, Muir AB, Liacouras CA, Spergel JM: Clinical tolerance in eosinophilic esophagitis. J Allergy Clin Immunol Pract. 6(2): 661-3, Mar 2017.

Cianferoni A, Ruffner MA, Guzek R, Guan S, Brown-Whitehorn T, Spergel JM: Activated Th2 cells and milk-specific Th2 cells are increased in milk-induced eosinophilic esophagitis. Annals of Allergy, Asthma & Immunology 120(2): 177–183, Feb 2018.

Fahey LM, Guzek R, Ruffner MA, Sullivan KE, Spergel J, Cianferoni A: EMSY is Increased and Activates TSLP & CCL5 Expression in Eosinophilic Esophagitis. Pediatric Allergy and Immunology 29(5): 565-568, Apr 2018.

Wang KY, Lee J, Cianferoni A, Ruffner MA, Dean A, Molleston JM, Pawlowski NA, Heimall J, Saltzman RW, Ram GS, Fiedler J, Gober LM, Spergel JM, Brown-Whitehorn TF: Food Protein-Induced Enterocolitis Syndrome Food Challenges: Experience from a Large Referral Center. J Allergy Clin Immunol Pract. 7(2): 444-450, Sept 2018.

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Last updated: 08/04/2023
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