Faculty

Kyong-Mi Chang, MD

faculty photo
Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
Corporal Michael J. Crescenz VA Medical Center
Medical Research Building A424
3900 Woodland Avenue
Philadelphia, PA 19104
Office: (215) 823-5893
Fax: (215) 823-4394
Lab: (215) 823-5800 ext 6730
Education:
A.B. (Chemistry, Mathematics, and Fine Arts)
Bryn Mawr College, 1983.
M.D.
The Medical College of Pennsylvania, 1987.
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Description of Research Expertise

Dr. Chang's research expertise is in immune mechanisms of viral persistence and disease pathogenesis with particularly focus in human hepatitis C and B viruses, +/- HIV confection--using high-dimensional single cell immune analysis via Flow and Mass Cytometry. As the Co-PI of a VA-funded genetic study of cardiometabolic diseases using the VA's Million Veterans Program (MVP), Dr. Chang is also examining the genetic basis of cardio metabolic disorders using big data involving clinical and genetic data. Since 2020, Dr. Chang has actively engaged in research involving COVID-19 given her expertise in clinical research as well as virology/immune pathogenesis.

Description of Clinical Expertise

Dr. Chang's clinical area of expertise is in the evaluation, treatment and study of patients with acute and chronic viral hepatitis B and C, with and without HIV coinfection. She established and directed the active GI/Liver clinic at the Philadelphia VA Medical Center in 1999-2012. She continues to supervise GI fellows and rotating students/residents in the GI/Liver clinic to date.

Description of Other Expertise

Dr. Chang is the Associate Chief of Research (ACOS/R&D) and Associate Dean for Research at the Philadelphia Corporal Michael J Crescenz VA Medical Center (CMCVAMC), which is academically affiliated with the University of Pennsylvania. As such, Dr. Chang has the administrative oversight in developing VA-based and/or VA-funded research (e.g. via VA Career Development Award, VA Merit Review, Cooperative Studies Program and MVP research). She is also committed to mentoring VA-based researchers both locally and nationally.

Selected Publications

Daghlas I, Karhunen V, Ray D, Zuber V, Burgess S, Tsao PS, Lynch JA, Lee KM, Voight BF, Chang KM, Baker EH, Damrauer SM, Howson JMM, Vujkovic M, Gill D: Genetic Evidence for Repurposing of GLP1R (Glucagon-Like Peptide-1 Receptor) Agonists to Prevent Heart Failure. J. Am. Heart Assoc. 10(13), July 2021.

R. Pazoki*, M. Vujkovic*, J. Elliott, E. Evangelou, D. Gill, M. Ghanbari, PJ van der Most, R. C. Pinto, M. Wielscher, M. Farlik, V. Zuber, R.J. de Knecht, H. Nieder, A. G. Uitterlinden, Lifelines Cohort Study, J. A. Lynch, X. Jiang, S. Said, D.E. Kaplan, K. M. Lee, M. Serper, R. M. Carr, P. S. Tsao, S. R. Atkinson, A. Dehghan, I. Tzoulaki, M A. Ikram, K-H. Herzig, M-R Jarvelin, B. Z. Alizadeh, C. J. O'Donnell, D. Saleheen, B. F. Voight*, K.M. Chang*, M. R. Thurz*, P. Elliott*, and the VA Million Veteran Program: Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzyme. Nature Communications 12(1), May 2021.

D. Traum, YJ Wang, KB Schwarz, J Schug, DKH Wong, HLA Janssen, NA Terrault, M Khalili, AS Wahed, KF Murray, P Rosenthal, SC Ling, N Rodriguez-Baez, RK Sterling, DTY Lau, TM Block, MD Feldman, EE Furth, WM Lee, DE Kleiner, AS Lok, KH Kaestner, KM Chang: Highly multiplexed 2-dimensional imaging mass cytometry analysis of HBV-infected liver. JCI Insight 6(7), April 2021.

MG Levin, D. Klarin, VM Walker, D Gill, J Lynch, JN Hellwege, JM Keaton, KM Lee, TL Assimes, P Natarajan, AM Hung, T Edwards, DJ Rader, JM Gaziano, NM Davies, PS Tsao, KM Chang, BF Voight, SD Damrauer: Association Between Genetic Variation in Blood Pressure and Increased Lifetime Risk of Peripheral Artery Disease. Arterioscler Thromb Vasc Biol April (in press) 2021.

WP Bone, KM Siewert, A Jha, D Klarin, SM Damrauer, VA Million Veteran Program, KM Chang, PS Tsao, TL Assimes, MD Ritchie, BF Voight: Multi-trait association studies discover pleiotropic loci between Alzheimer's disease and cardiometabolic traits. Alzheimer Res There 13(1), February 2021.

Fix OK*, Blumberg EA, Chang KM, Chu J, Chung RT, Goacher EK, Hameed B, Kaul DR, Kulik LM, Kwok RM, McGuire BM, Mulligan DC, Price JC, Reau NS, Reddy KR, Reynolds A, Rosen HR, Russo MW, Schilsky ML, Verna EC, Ward JW, Fontana RJ*, for the AALSD COVID-19 Vaccine Working Group.: AASLD Expert Panel Consensus Statement: Vaccines to Prevent COVID-19 Infection in Patients with Liver Disease. Hepatology February 2021.

MG Levin, D Klarin, TL Assimes, MS Freiberg, E Ingelsson, J Lynch, P Natarajan, C O'Donnell, DJ Rader, PS Tsao, KM Chang, BF Voight, SM Damrauer for the VA Million Veteran Program: Genetics of Smoking and Risk of Atherosclerotic Cardiovascular Diseases: A Mendelian Randomization Study. JAMA Netw Open 4(1), January 2021.

Small AM, Huffman JE, Klarin D, Sabater-Lleal M, Lynch JA, Assimes TL, Sun YV, Miller D, Freiberg MS, Morrison AC, Rader DJ, Wilson PWF, Cho K, Tsao PS, Chang KM, Smith NL, O'Donnell CJ, de Vries PS, Damrauer SM; Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Hemostasis Working Group and the VA Million Veteran Program.: Mendelian Randomization Analysis of Hemostatic Factors and Their Contribution to Peripheral Artery Disease-Brief Report. Arterioscler Thromb Vasc Biol 41 (1): 380-386, Jan 2021.

Thom CS, Ding Z, Levin MG, Damrauer SM, Lee KM, Lynch J, Chang KM, Tsao PS, Cho K, Wilson PWF, Assimes TL, Sun YV, O'Donnell CJ, VA Million Veteran Program, Vujkovic M, Voight BF: Genetic determinants of increased body mass index mediate the effect of smoking on increased risk for type 2 diabetes but not coronary artery disease. Hum Mol. Genet 29(19), November 2020.

Small A, Huffman J, Klarin D, Lynch JA, Assimes T, Duvall S, Sun Y, Shere L, Natarajan P, Gaziano M, Rader D, Wilson P, Tsao P, Chang KM, Cho K, O'Donnell C, Casas J, Damrauer S: PCSK9 loss of function is protective against extra-coronary atherosclerotic cardiovascular disease in a large multi-ethnic cohort. PLOS One November 2020.

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Last updated: 08/16/2021
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