Faculty

Kyong-Mi Chang, MD

Professor of Medicine (Gastroenterology)

Department: Medicine

Graduate Group Affiliations

Contact information

Corporal Michael J. Crescenz VAMC &
University of Pennsylvania Perelman School of Medicine
3900 Woodland Avenue
Philadelphia, PA 19104

Office: (215) 823-5893
Lab: (215) 823-5800 ext 6730

Email:
kmchang@pennmedicine.upenn.edu

Publications

Search PubMed for articles

Education:
A.B. (Chemistry, Mathematics, and Fine Arts)
Bryn Mawr College, 1983.
M.D.
The Medical College of Pennsylvania, 1987.

Links
Search PubMed for articles
Penn Medicine Liver Diseases Program
Cell and Molecular Biology graduate group faculty webpage.
Corporal Michael J. Crescenz VA Medical Center
Primary Work Website

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Research Expertise

Dr. Chang's research expertise is in immune mechanisms of viral persistence and disease pathogenesis with a focus on human hepatitis C and B viruses, +/- HIV confection. As the Co-PI of a VA Merit award using the VA's Million Veterans Program (MVP), Dr. Chang is also conducting population-based genomic analyses of cardiometabolic disorders including MASLD/NAFLD and liver disease progression to cirrhosis and HCC--in collaboration with other large national and international genomic cohorts.

Description of Clinical Expertise

Dr. Chang's clinical area of expertise is in the evaluation, treatment and study of patients with acute and chronic liver disease (e.g. HBV, HCV, NAFLD). She established and directed the active GI/Liver clinic at the Philadelphia VA Medical Center in 1999-2012. She continues to supervise GI fellows and rotating students/residents in the GI/Liver clinic to date.

Description of Other Expertise

As the Associate Chief of Staff for Research (ACOS/R&D) and Associate Dean for Research at the Philadelphia Corporal Michael J Crescenz VA Medical Center (CMCVAMC), Dr. Chang leads the VA research program and has the administrative oversight in developing VA-based and/or VA-funded research (e.g. via VA Career Development Award, Merit Review, Cooperative Studies Program and MVP research) at the CMCVAMC. She is committed to mentoring VA-based researchers both locally and nationally.

Selected Publications

Yang G, Alarcon C, Chanfreau C, Lee NH, Friedman P, Nutescu E, Tuck M, O'Brien T, Gong L, Klein TE, Chang KM, Tsao PS, Meltzer DO, Lynch JA; Million Veteran Program; Tuteja S, Perera MA.: Investigation of Genomic and Transcriptomic Risk Factors of Clopidogrel Response in African Americans. Clin Pharmacol Ther January 2025.

Zhang X, Chang KM, Yu J, Loomba R.: Unraveling Mechanisms of Genetic Risks in Metabolic Dysfunction-Associated Steatotic Liver Diseases: A Pathway to Precision Medicine. Annu Rev Pathol 20(1): 375-403, Jan 2025.

SJ Jurgens, JT Rämö, DR Kramarenko, LFJM Wijdeveld, J Haas, MD Chaffin, S Garnier, L Gaziano, LC Weng, A Lipov, SL Zheng, Al Henry, JE Huffman, S Challa, F Rühle, CD Verdugo, CK Juárez, S Kany, CA van Orsouw, K Biddinger, E Poel, AL Elliott, X Wang, C Francis, R Ruan, S Koyama, L Beekman, DS Zimmerman, JF Deleuze, E Villard, DA Trégouët, R Isnard, FinnGen, VA Million Veteran Program, HERMES Consortium, DI Boomsma, EJC de Geus, R Tadros, YM Pinto, AAM Wilde, JJ Hottenga, J Sinisalo, T Niiranen, R Walsh, AF Schmidt, SH Choi, KM Chang, PS Tsao, PM Matthews, JS Ware, RT Lumbers, S van der Crabben, J Laukkanen, A Palotie, AS Amin, P Charron, B Meder, PT Ellinor, M Daly, KG Aragam, CR Bezzina: Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience. Nature Genetics 56(12): 1-10, December 2024.

Yu YH, Pridgen KM, Nelson TJ, Miller DR, Wells JM, Assimes TL, O'Donnell CJ, Tsao PS, Chang KM, Lynch JA.: Oral Health, Inflammation, and Cardiometabolic Factors in the VA Million Veteran Program. JDR Clin Trans Res Dec 2024.

Kaplan DE, Teerlink CC, Schwantes-An TH, Norden-Krichmar TM, DuVall SL, Morgan TR, Tsao PS, Voight BF, Lynch JA, Vujković M, Chang KM: Clinical and genetic risk factors for progressive fibrosis in metabolic dysfunction-associated steatotic liver disease. Hepatol Commun July 2024.

Ghouse J, Sveinbjörnsson G, Vujkovic M, Seidelin AS, Gellert-Kristensen H, Ahlberg G, Tragante V, Rand SA, Brancale J, Vilarinho S, Lundegaard PR, Sørensen E, Erikstrup C, Bruun MT, Jensen BA, Brunak S, Banasik K, Ullum H; DBDS Genomic Consortium; Verweij N, Lotta L, Baras A; Regeneron Genetics Center; Mirshahi T, Carey DJ; Geisinger-Regeneron DiscovEHR Collaboration; VA Million Veteran Program; Kaplan DE, Lynch J, Morgan T, Schwantes-An TH, Dochtermann DR, Pyarajan S, Tsao PS; Estonian Biobank Research Team; Laisk T, Mägi R, Kozlitina J, Tybjærg-Hansen A, Jones D, Knowlton KU, Nadauld L, Ferkingstad E, Björnsson ES, Ulfarsson MO, Sturluson Á, Sulem P, Pedersen OB, Ostrowski SR, Gudbjartsson DF, Stefansson K, Olesen MS, Chang KM, Holm H, Bundgaard H, Stender S.: Integrative common and rare variant analyses provide insights into the genetic architecture of liver cirrhosis. Nat Genet May 2024.

Suzuki K, Hatzikotoulas K, Southam L, Taylor HJ, Yin X, Lorenz KM, Mandla R, Huerta-Chagoya A, Melloni GEM, Kanoni S, Rayner NW, Bocher O, Arruda AL, Sonehara K, Namba S, Lee SSK, Preuss MH, Petty LE, Schroeder P, Vanderwerff B, Kals M, Bragg F, Lin K, Guo X, Zhang W, Yao J, Kim YJ, Graff M, Takeuchi F, Nano J, Lamri A, Nakatochi M, Moon S, Scott RA, Cook JP, Lee JJ, Pan I, Taliun D, Parra EJ, Chai JF, Bielak LF, Tabara Y, Hai Y, Thorleifsson G, Grarup N, Sofer T, Wuttke M, Sarnowski C, Gieger C, Nousome D, Trompet S, Kwak SH, Long J, Sun M, Tong L, Chen WM, Nongmaithem SS, Noordam R, Lim VJY, Tam CHT, Joo YY, Chen CH, Raffield LM, Prins BP, Nicolas A, Yanek LR, Chen G, Brody JA, Kabagambe E, An P, Xiang AH, Choi HS, Cade BE, Tan J, Broadaway KA, Williamson A, Kamali Z, Cui J, Thangam M, Adair LS, Adeyemo A, Aguilar-Salinas CA, Ahluwalia TS, Anand SS, Bertoni A, Bork-Jensen J, Brandslund I, Buchanan TA, Burant CF, Butterworth AS, Canouil M, Chan JCN, Chang LC, Chee ML, Chen J, Chen SH, Chen YT, Chen Z, Chuang LM, Cushman M…….. Chang KM, MI McCarthy, JB Meigs, A Mahajan, CN Spracklen, JM Mercader, M Boehnke, JI Rotter, M Vujkovic, BF Voight, AP Morris and E Zeggini: Genetic drivers of heterogeneity in type 2 diabetes pathophysiology. Nature March 2024.

Smith JL, Tcheandjieu C, Dikilitas O, Iyer K, Miyazawa K, Hilliard A, Lynch J, Rotter JI, Chen YI, Sheu WH, Chang KM, Kanoni S, Tsao P, Ito K, Kosel M, Clarke SL, Schaid DJ, Assimes TL, Kullo IJ.: Multi-Ancestry Polygenic Risk Score for Coronary Heart Disease Based on an Ancestrally Diverse Genome-Wide Association Study and Population-Specific Optimization. Circ Genom Precis Med Feb 2024.

Scorletti E, Saiman Y, Jeon S, Schneider CV, Buyco DG, Lin C, Himes BE, Mesaros CA, Vujkovic M, Creasy KT, Furth EE, Billheimer JT, Hand NJ, Kaplan DE, Chang KM, Tsao PS, Lynch JA, Dempsey JL, Harkin J, Bayen S, Conlon D, Guerraty M, Phillips MC, Rader DJ, Carr RM.: A missense variant in human perilipin 2 (PLIN2 Ser251Pro) reduces hepatic steatosis in mice. JHEP Rep 6: 100902, Oct 2023.

Manning A, Sevilla-González M, Smith K, Wang N, Jensen A, Litkowski E, Kim H, DiCorpo D, Westerman K, Cui J, Liu CT, Yu C, McNeil J, Lacaze P, Chang KM, Tsao P, Phillips L, Goodarzi M, Sladek R, Rotter J, Dupuis J, Florez J, Merino J, Meigs J, Zhou J, Raghavan S, Udler M.: Heterogeneous effects on type 2 diabetes and cardiovascular outcomes of genetic variants and traits associated with fasting insulin. Res Sq 19: rs.3.rs-3317661, Sept 2023.