Michael Silverman, MD, PhD

faculty photo
Assistant Professor of Pediatrics (Infectious Diseases)
Department: Pediatrics
Graduate Group Affiliations

Contact information
Children's Hospital of Philadelphia
Division of Infectious Diseases
3615 Civic Center Blvd
Philadelphia, PA 19104
BS (Biology)
Cornell University, 1998.
MD, PhD (Medicine and Immunology)
University of Pennsylvania School of Medicine, 2007.
Permanent link
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Description of Clinical Expertise

Immunocompromised patients

Description of Research Expertise

Microbiome, Immunology, HLA, MHC, antibiotics, intestinal immune system, autoimmune (type I) diabetes, IgA deficiency, Early life immune system development

Selected Publications

Conrey PE, Denu L, O'Boyle KC, Rozich I, Green J, Maslanka J, Lubin JB, Duranova T,Haltzman BL, Gianchett L, Oldridge DA, De Luna N, Vella LA, Allman D, Spergel J, Tanes C, Bittinger K, Henrickson SE, Silverman MA: IgA deficiency destabilizes homeostasis toward intestinal microbes and increases systemic immune dysregulation. Science Immunology May 2023

Jean-Bernard Lubin, Jamal Green, Sarah Maddux, Lidiya Denu, Tereza Duranova, Matthew Lanza, Meghan Wynosky-Dolfi, Igor E. Brodsky, Paul J. Planet, Michael A. Silverman: Arresting microbiome development limits immune system maturation and resistance to infection. Cell Host and Microbe March 2023 Notes: https://doi.org/10.1016/j.chom.2023.03.006.

Alexander B. Smith, Matthew L. Jenior, Orlaith Keenan, Jessica L. Hart, Jonathan Specker, Arwa Abbas, Paula C. Rangel, Chao Di, Jamal Green, Jennifer A. Gaddy, Maribeth R. Nicholson, Clare Laut, Jason A. Papin, Frederic D. Bushman, Jessi Erlichman, Robert Baldassano, Michael A. Silverman, Gary M. Dunny1, Boone M. Prentice, Eric P. Skaar, Joseph P. Zackular: Microbial Cooperation Enhances Clostridioides difficile Pathogenesis. Nature Sep 2022.

Sarah Maddux, Jamal Green, Jean-Bernard Lubin, Julia Flores, Isaiah Rozich, Tereza Duranova, Paul J. PlanetMichael A. Silverman: Akkermansia muciniphila modulates adaptive immunity to commensal microbes in young NOD mice bioRxiv Page: https://doi.org/10.1101/2022.08.16.504185, August 2022.

Silverman MA and Green JL. : Insight into host-microbe interactions using microbial flow cytometry coupled to next generation sequencing. Journal of the Pediatric Infectious Diseases Society 10: S106-S111, December 2021.

Robert B Lindell, Michael S Wolf, Alicia M Alcamo, Michael A Silverman, Daniel E Dulek, William R Otto, Timothy S Olson, Carrie L Kitko, Paisit Paueksakon and Kathleen Chiotos: Immune dysregulation due to Toxoplasma gondii reactivation after allogeneic hematopoietic cell transplant: a case series and review of the literature. Frontiers in Pediatrics 10(9): 719679, August 2021.

Conrey P, Denu L, O’Boyle K, Green J, Maslanska J, Lubin J, Duranova T, Haltzman B, Gianchetti L, Oldridge D, Vella L, Allman D, Spergel J, Tanes C, Bittinger K, Hernrickson S, Silverman M.: IgA deficiency destabilizes immunological homeostasis towards intestinal microbiota and increases the risk of systemic immune dysregulation. medRxiv Page: doi.org/10.1101/2021.08.20.21261620, August 2021.

Stephanie Si , Kelley Erickson , Nicholas Evageliou , Michael Silverman , Leslie Kersun : An Usual Presentation of Pneumocystis jirovecii Pneumonia in a Woman Treated With Immune Checkpoint Inhibitor. J Pediatric Hematol Oncol 43(1): 163-164, March 2021.

Alam Z, Devalaraja S, Li M, To TKJ, Folkert IW, Mitchell-Velasquez E, Dang MT, Young P, Wilbur CJ, Silverman MA, Li X, Chen YH, Hernandez PT, Bhattacharyya A, Bhattacharya M, Levine MH, Haldar M.: Counter Regulation of Spic by NF-κB and STAT Signaling Controls Inflammation and Iron Metabolism in Macrophages. Cell Rep. 31(13): 107825, June 2020.

Mathew S. Kelly and Michael A. Silverman: Microbiome Implications in Transplantation and Oncology. Pediatric Transplant and Oncology Infectious Diseases 37(1): 1632-1640, April 2020.

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Last updated: 12/07/2023
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