Scott Michael Gordon, MD, PhD

faculty photo
Assistant Professor of Pediatrics (Neonatology & Newborn Services)
Department: Pediatrics
Graduate Group Affiliations

Contact information
Children's Hospital of Philadelphia
Abramson Pediatric Research Center
3615 Civic Center Blvd
11th Floor, Office 1107C
Philadelphia, PA 19104
Office: 503-807-7980
BS (Biology)
Haverford College, 2006.
Ph.D. (Immunology)
Perelman School of Medicine, University of Pennsylvania, 2011.
Perelman School of Medicine, University of Pennsylvania, 2013.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Description of Clinical Expertise

I am an attending physician in the Neonatal Intensive Care Unit of Children's Hospital of Philadelphia and the Hospital of the University of Pennsylvania.

Description of Research Expertise

The Gordon Lab wants to know how the maternal immune system and the developing placenta communicate with each other. Historically, the maternal-fetal interface has been viewed in the same light as other immune-privileged sites in the body, to explain why a mother’s immune system doesn’t view the fetus as a partially foreign organ and reject it. In truth, the maternal-fetal interface is loaded with immune cells that directly interact with fetal cells throughout pregnancy. Likewise, a growing list of inflammatory molecules released by immune cells play key roles to support a healthy pregnancy. If we can understand how these molecules send signals back and forth between mom and fetus, we may be able to change the course of such life-threatening conditions as preeclampsia, intrauterine growth restriction, congenital infections, and premature birth.

Selected Publications

Kanter J*, Gordon SM*, Mani S, Sokalska A, Park JY, Senapati S, Huh DD, Mainigi M.: Hormonal stimulation reduces numbers and impairs function of human uterine natural killer cells during implantation. Hum Reprod Apr 2023.

Burn TN, Miot C, Gordon SM, Culberson EJ, Diamond T, Kreiger PA, Hayer KE, Bhattacharyya A, Jones JM, Bassing CH, Behrens EM.: The RAG1 Ubiquitin Ligase Domain Stimulates Recombination of TCRβ and TCRα Genes and Influences Development of αβ T Cell Lineages. J Immunol 209: 938-949, Sep 2022.

Ju Young Park, Sneha Mani, Geremy Clair, Heather M. Olson, Vanessa L. Paurus, Charles K. Ansong, Cassidy Blundell, Rachel Young, Jessica Kanter, Scott M. Gordon, Alex Y. Yi, Monica Mainigi, and Dan Dongeun Huh: A microphysiological model of human trophoblast invasion during implantation. Nature Communications 3: 1252, March 2022.

Scott M. Gordon and Amy E. O’Connell: Inborn Errors of Immunity in the Premature Infant: Challenges in Recognition and Diagnosis. Frontiers in Immunology 12: 758373, Dec 2021.

Scott M. Gordon: Interleukin-15 in Outcomes of Pregnancy. International Journal of Molecular Sciences 22(20): 11094, Oct 2021.

Jessica Kanter,Sneha Mani, Scott M. Gordon, Monica Mainigi: Uterine Natural Killer Cell Biology and Role in Early Pregnancy Establishment and Outcomes. F&S Reviews 2(4): 265-286, Oct 2021.

Scott M. Gordon, Lakshmi Srinivasan, Mary C. Harris, and Laurie E. Kilpatrick: Cytokines and Inflammatory Response in the Fetus and Neonate. Polin: Fetal and Neonatal Physiology, 6th Edition. Richard Polin, Steven Abman, David Rowitch, William Benitz (eds.). Page: 1243, July 2021 Notes: ISBN: 9780323712842.

Scott M. Gordon, Shelley M. Lawrence, and James L. Wynn: Bacterial Meningitis. Remington and Klein's Infectious Diseases of the Fetus and Newborn Infant, 9th Edition 2021 Notes: Accepted.

Shelley M. Lawrence, James L. Wynn, and Scott M. Gordon: Bacterial Sepsis. Remington and Klein's Infectious Diseases of the Fetus and Newborn Infant, 9th Edition 2021 Notes: Accepted.

Liza Johannesson, Giuliano Testa, Rebecca Flyckt, Ruth Farrell, Cristiano Quintini, Anji Wall, Kathleen O'Neill, Andreas Tzakis, Elliott G. Richards, Scott M. Gordon, Paige M. Porrett: Guidelines for Standardized Nomenclature and Reporting in Uterus Transplantation: An Opinion From the United States Uterus Transplant Consortium. American Journal of Transplantation 20(12): 3319-3325, Dec 2020.

back to top
Last updated: 08/24/2023
The Trustees of the University of Pennsylvania