Brian D. Keith

faculty photo
Adjunct Professor of Cancer Biology
Department: Cancer Biology

Contact information
Abramson Family Cancer Research Institute
University of Pennsylvania
421 Curie Blvd.
Philadelphia, PA 19104
Office: 215 746-5533
Fax: 215 746-5511
Graduate Group Affiliations
Sc B (Biology)
Brown University, 1980.
Ph.D. (Plant Molecular Biology)
The Rockefeller University, 1987.
Post-Graduate Training
Research Assistant (Dr. Sidney Strickland), Rockfeller University, 1980-1981.
Postdoctoral Fellow (Dr. Nam-Hai Chua), Rockefeller University, 1987-1988.
Postdoctoral Fellow (Dr. Gerald R. Fink) , Whitehead Institute for Biomedical Research , 1988-1992.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Description of Research Expertise

Research Interests
How cells and tissues adapt to oxygen deprivation (hypoxia) by modifying gene expression.

Key words: mouse, development, transcription, hypoxia, cancer.

Description of Research
As part of a long-standing collaboration with Dr. Celeste Simon, I generate mouse models in which genes encoding critical components of the hypoxic response pathway are mutated. These and related genetic and cell biological tools offer insights into physiological and metabolic responses to hypoxia and other tumor microenvironmental stresses. Previously, I also collaborated with Dr. Carl June on adapting CAR-T cell therapy to solid tumors, focusing on the effects of the tumor microenvironment on CAR-T cell metabolism and function.

Rotation Projects
Students interested in rotation projects should refer to Dr. Celeste Simon's lab page.

Lab personnel:
Please refer to Dr. Celeste Simon's lab

Selected Publications

Li, B., Qiu, B., Lee, D.S.M., Walton, Z., Ochocki, J., Mathew, L.K., Mancuso, A., Gade, T.P.F., Keith, B., Nissim, I., and Simon, M.C.: Fructose-1,6-bisphosphatase opposes renal carcinoma progression. Nature 513: 251-255, Sept 2014.

Mathew, L.K., Skuli, N., Mucaj, V., Lee, S.S., Zinn, P.O., Sathyan, P., Imtiyaz, H.Z., Zhang, Z., Davuluri, R.V., Rao, S., Venneti, S., Lal, P., Lathia, J.D., Rich, J.N., Keith, B., Minn, A.J., Simon, M.C. : miR-218 opposes a critical RTK-HIF pathway in mesenchymal glioblastoma. Proc. Nat. Acad. Sci. USA 111: 291-296., Jan 2014.

Mathew L.K., Lee, S.S., Skuli, N., Rao, S., Keith, B., Nathanson, K.L., Lal, P., Simon, M.C. : Restricted expression of miR-30c-2-3p and miR-30a-3p in clear cell renal cell carcinoma enhances HIF-2 activity. Cancer Discovery 4: 53-60, Jan 2014.

Arsenault Patrick R, Pei Fei, Lee Rebecca, Kerestes Heddy, Percy Melanie J, Keith Brian, Simon M Celeste, Lappin Terence R J, Khurana Tejvir S, Lee Frank S: A Knockin Mouse Model of Human PHD2-Associated Erythrocytosis Establishes a Haploinsufficiency Mechanism. The Journal of biological chemistry Oct 2013.

Young Regina M, Ackerman Daniel, Quinn Zachary L, Mancuso Anthony, Gruber Michaela, Liu Liping, Giannoukos Dionysios N, Bobrovnikova-Marjon Ekaterina, Diehl J Alan, Keith Brian, Simon M Celeste: Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress. Genes & development 27(10): 1115-31, May 2013.

Skuli N, Majmundar AJ, Krock BL, Mesquita RC, Mathew LK, Quinn ZL, Runge A, Liu L, Kim MN, Liang J, Schenkel S, Yodh AG, Keith B, Simon MC: Endothelial HIF-2α regulates murine pathological angiogenesis and revascularization processes. J. Clin. Invest. 122(4): 1427-43, Apr 2012.

Keith B, Johnson RS, Simon MC: HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression. Nature Reviews Cancer 12(1): 9-22, Jan 2012.

Skuli, N., Majmundar, A., Mesquita, R., Quinn, Z., Runge, A., Liu, L., Gruber, M., Kim, M., Liang, J., Schenkel, S., Yodh, A., Keith, B., and Simon, M.C: Endothelial hypoxia inducible factor-2 (HIF-2) regulates murine pathological angiogenesis and revascularizaiton. J. Clin. Invest. 122 : 1427-1443, 2012.

Imtiyaz HZ, Williams EP, Hickey MM, Patel SA, Durham AC, Yuan L-J, Hammond R, Gimotty PA, Keith B, and Simon MC.: Hypoxia factor 2-alpha regulates macrophage function in mouse models of acute and tumor inflammation. J. Clin. Invest. 120(8): 2699-714, July 2010.

Kapitsinou PP, Liu Q, Unger TL, Rha J, Davidoff O, Keith B, Epstein JA, Moores SL, Erickson-Miller CL, and Haase VH: Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia. Blood July 2010.

back to top
Last updated: 06/11/2021
The Trustees of the University of Pennsylvania
© The Trustees of the University of Pennsylvania | Site best viewed in a supported browser. | Site Design: PMACS Web Team.