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Faculty

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Amelia J. Eisch, Ph.D.

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Professor of Anesthesiology and Critical Care
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Department: Anesthesiology and Critical Care
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Abramson Research Center, Room 402D
3f 3615 Civic Center Drive
Philadelphia, PA 19104-4399
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40 Office: sites.google.com/view/eischlab
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Email: eischa@chop.edu
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18 Publications
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Links
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13 Education:
21 9 B.A. 1f (Psychology/Biology) c
28 Yale University, 1990.
 21 a Ph.D. 21 (Biological Sciences ) c
39 University of California, Irvine, 1997.
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Description of Other Expertise

3f9 In addition to my neuroscience expertise, I have extensive experience mentoring trainees. From 2000 until my move to PennMed/CHOP in 2016, I trained 11 postdoctoral, 13 predoctoral, 26 undergraduates, and 29 high school students in the laboratory. At UT Southwestern, I was Principal Investigator from 2008 until 2016 (when I moved to PennMed/CHOP) of a NIDA T32 training grant (DA T32007290) which provided training for 6 predoctoral and 5 postdoctoral trainees each year in basic translational research. Since having moved my group to PennMed/CHOP, I have hosted predoctoral trainees for rotation experiences, as well as undergraduate/high school students for summer research experiences. I have also been named co-Director of an NINDS T32 training grant on neurodevelopmental disorders (Director: Mike Robinson), and been appointed to the Executive Committee for the PennMed Neuroscience Graduate Group. These activities demonstrate my commitment to training the next generation of neuroscientists.
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Description of Research Expertise

307 I am neuroscientist with a broad interest in how molecular and cellular changes – such as the changes in the number of neurons generated in the hippocampus, a brain region important for learning/memory and regulation of anxiety and the stress response – influence both normal behavior and cognitive functioning. I am interested in how developmental and adult neurogenesis in particular and dentate gyrus plasticity in general contribute to abnormal functioning with relevance to developmental, psychiatric, and neurological disorders. Current Eisch Lab projects span genetic, molecular, cellular, circuit, and functional/behavioral levels, and are funded by NASA and NIH (both the National Institute on Drug Abuse and National Institute on Mental Health).
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Selected Publications

118 Wittenberg RE, Yun S, Yang K, Swanson OK, Wolfman SL, Colon LM, Dani JA*, Eisch AJ*: Paradoxical VTA GABA signaling drives enhanced morphine reward after adolescent nicotine. Biological Psychiatry June 2025.

 183 Bancroft GL, Mahajan A, Babiker NA, Yun S, Eisch AJ. : Isolating lateral entorhinal cortex (LEC)-dentate gyrus (DG) circuit function during memory retrieval of a behavioral pattern separation task. CHOP Poster Day and Scientific Symposium 2025. Philadelphia, PA. Notes: Poster Presentation, AWARD WINNER May 2025.

 1ae Leland SP, Bancroft GL, Haas HA, Shi R, Kumar PL, Kiffer F, Eisch AJ, Yun S. : Differential behavioral signatures between stress-susceptible from stress-resilient mice during social avoidance test in the chronic social defeat stress model. CHOP Poster Day and Scientific Symposium 2025. Philadelphia, PA. Notes: Poster Presentation, AWARD WINNER May 2025.

 16a Colon LM, Petrilli Fortuna R, Shroff S, Yun S, Eisch AJ. : Targeting Memory Systems to Combat Drug Addiction: Sex-Specific Approaches to Disrupting Reward-Context Memories. CHOP Poster Day and Scientific Symposium 2025. Philadelphia, PA. Notes: Poster Presentation, AWARD WINNER May 2025.

 15f Espina Vazquez L, Kiffer FC, Babiker NA, Bancroft GL, O’Connor S, Yun S, Eisch AJ. : Mars-Relevant Space Radiation Alters Social Conflict Processing Networks in Mice. Philadelphia Chapter of the Society for Neuroscience. Philadelphia, PA. Notes: Poster Presentation. May 2025.

 c3 Karamanides PG, Bancroft GL, Mahajan A, Yun S, Eisch AJ. : Behavioral Pattern Separation: Understanding How the Brain Creates Distinct Memories. 86 Philadelphia Chapter of the Society for Neuroscience. Philadelphia, PA. Notes: Poster Presentation. May 2025.

 143 Mahajan A, Bancroft GL, Babiker NA, Eisch AJ, Yun S. : Storing Similar Episodic Memories: Investigating LEC Fan Cells during Memory Consolidation. CHOP Poster Day and Scientific Symposium 2025. Philadelphia, PA. Notes: Poster Presentation. May 2025.

 140 Karamanides PG, Bancroft GL, Mahajan A, Yun S, Eisch AJ. : Behavioral Pattern Separation: Understanding How the Brain Creates Distinct Memories. CHOP Poster Day and Scientific Symposium 2025. Philadelphia, PA.Notes: Poster Presentation. May 2025.

 17a Leland SP, Bancroft GL, Haas HA, Shi R, Kumar PL, Kiffer F, Eisch AJ, Yun S. : Distinguishing Motor Behavioral Signatures Between Stress-Susceptible and Resilient Mice During Social Avoidance Test in a Chronic Social Defeat Stress Model. UPenn CURF Spring Research Expo 2025. Philadelphia, PA. May 2025.

 14a Colon LM, Petrilli Fortuna R, Shroff S, Yun S, Eisch AJ. : Targeting Memory Systems to Combat Drug Addiction: Sex-Specific Approaches to Disrupting Reward-Context Memories. International Meeting on Engrams in Learning and Memory. Dublin, Ireland. May 2025.

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