Faculty

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Frances Elizabeth Jensen, MD, FACP, FANA, FAAN, FAES

Arthur Knight Asbury, M.D. Professor in Neurology

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Department: Neurology

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1f Graduate Group Affiliations 8

Pharmacology
Neuroscience

46 Contact information
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Hospital of the University of Pennsylvania
23 Perelman School of Medicine
20 Department of Neurology
1e 3 West Gates Building
35 3400 Spruce Street
Philadelphia, PA 19104

2e Office: 215-662-3360
32 Fax: 215-662-3362
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Links
33 Jensen Lab
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13 Education:
21 9 A.B. 1c (Neuropsychology) c
26 Smith College, 1978.
21 9 M.D. 15 (Medicine) c
3b Cornell University Medical College, 1983.
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3 3 3 3 92 Permanent link
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dc SOM Home » BGS Home » NGG Home » Neurobiology of Disease a

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Description of Clinical Expertise

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Description of Research Expertise

22a Dr. Jensen is Professor of Neurology and Chairman of Neurology at the Perelman School of Medicine, University of Pennsylvania, and Co-Director of Penn Translational Neuroscience Center. She was formerly Professor of Neurology, Harvard Medical School, Director of Translational Neuroscience and senior neurologist at Boston Children’s Hospital and Brigham and Women’s Hospital. She is a graduate of Cornell Medical College and obtained her neurology residency training at the Harvard Longwood Neurology Residency Program. Her research
239 focuses on mechanisms of epilepsy and stroke, and the mechanistic interaction of epilepsy with other disorders such as autism and dementia, with specific emphasis on elucidating new therapies for clinical trials development. Dr. Jensen received the 2007 Director’s Pioneer Award from the NIH to explore the interaction between epileptogenesis and cognitive dysfunction, and was elected as a member of the National Academy of Medicine in 2015. Dr. Jensen was President of the American Epilepsy Society in 2012, has served on a number of other leadership boards
2f1 including Society for Neuroscience, NIH, and is currently President-Elect for the American Neurological Association. She has authored over 150 manuscripts on subjects related to her research and has been continuously funded by NIH since 1987 and received a NIH-NINDS Javits Award in 2020. Dr. Jensen has trained numerous clinical and basic research fellows who now hold independent faculty positions nationally and internationally. Dr. Jensen is a Trustee of the Franklin Institute in Philadelphia and is involved in community outreach for brain research and education. In addition, Dr. Jensen is an advocate for awareness of the adolescent brain development, its unique strengths and vulnerabilities, as well as their impact on medical, social,
d3 and educational issues unique to teenagers and young adults, and author of the book “The Teenage Brain”, released by Harper Collins in 2015/16, translated and published in over 25 languages worldwide.
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Selected Publications

136 Gourmaud, S*, Shou, H, Irwin, D, Sansalone, K, Jacobs, L, Lucas, T, Davis, K, Jensen FE, Talos, D. : Alzheimer-like amyloid and tau pathology associated with cognitive deficit in temporal lobe epilepsy. Brain 143((1)): 191-209, Jan 2020.

133 Sun, H, Takesian, AE, Wang, TT, Lippman-Bell, JJ, Hensch, TK, and Jensen, FE. : Early seizures prematurely unsilence auditory synapses to disrupt thalamocortical critical period plasticity. Cell Reports 23(9): 2533-2540, May 2018.

82 Talos DM, Jacobs LM, Gourmaud S, Coto CA, Sun H, Lim KC, Lucas TH, Davis KA, Martinez ac Lage M, Jensen FE: Mechanistic target of rapamycin complex 1 and 2 in human temporal lobe epilepsy. Ann Neurol. 83(2): 311-327, January 2018.

116 Dzhala, VL, Talos, DM, Sdrulla, DA, Brumback, AC, Mathews, GC, Benk, TA, Delpire, EJ, Jensen, FE, Staley, KJ: NKCC1 transporter facilitates seizures in the developing brain. Nat Med 11: 1207-1213, 2005.

c5 Rakhade, S, Jensen, FE: Epileptogenesis in the Immature Brain: Emerging Mechanisms. Nature Rev Neurol 5(7): 380-91, 2009.

161 Sun, H*, Kosaras, B, Klein, P, Jensen, FE: Mammalian target of rapamycin complex 1 activation negatively regulates Polo-like kinase 2-mediated homeostatic compensation following neonatal seizures. Proc Natl Acad Sci U S A. Proc Nat Acad Sci (PNAS) 110(13): 5199-204, Mar 26 2013.

252 Sengupta Soma, Weeraratne Shyamal Dilhan, Sun Hongyu, Phallen Jillian, Rallapalli Sundari K, Teider Natalia, Kosaras Bela, Amani Vladimir, Pierre-Francois Jessica, Tang Yujie, Nguyen Brian, Yu Furong, Schubert Simone, Balansay Brianna, Mathios Dimitris, Lechpammer Mirna, Archer Tenley C, Tran Phuoc, Reimer Richard J, Cook James M, Lim Michael, Jensen Frances E, Pomeroy Scott L, Cho Yoon-Jae: α5-GABAA receptors negatively regulate MYC-amplified medulloblastoma growth. Acta neuropathologica 127(4): 593-603, Nov 2013.

f3 Frances E. Jensen with Amy Ellis Nutt: The Teenage Brain: A Neuroscientist's Survival Guide to Raising Adolescents and Young Adults. Harper Collins. Harper, January 2015.

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