Faculty

Shaon Sengupta, MBBS, MPH, FAAP

Assistant Professor of Pediatrics (Neonatology & Newborn Services)

Department: Pediatrics

Graduate Group Affiliations

Contact information

Children's Hospital of Philadelphia
Abramson Research Center
3615 Curie Blvd
Office: 1102C
Lab 1103
Philadelphia, PA 19104

Office: 267-426-6628
Fax: 215-590-4267

Education:
MBBS
All India Institute of Medical Sciences, India (Medicine and Surgery) , 2006.
MPH
Johns Hopkins Bloomberg School of Public Health (Epidemiology and Statistics), 2008.

Links
Twitter website

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Clinical Expertise

Neonatology, ECMO, NRP

Description of Research Expertise

Circadian biology, Lung inflammation, Neonatal lung injury, Influenza, Lung regeneration, Lung organoids

Selected Publications

Paul O, Brooks TG, Assi L, Shetty A, Towers M, Forrest KM, Cameron A, Sehgal A, Grant GR, Sengupta S.: Effect of external cues on clock-driven protection from Influenza A infection. JCI Page: In press, Nov 2025 Notes: doi: 10.1101/2025.03.03.641279.

Sengupta S*, Lee Y, Tao JQ, Akolia I, Louneva N, Forrest K, Paul O, Brooks TG, Grant GR, Sehgal A, Chatterjee S*: Circadian Control of Pulmonary Endothelial Signaling occurs via NADPH oxidase 2-NLRP3 pathway. J Biol Rhythms 40(6): doi: 10.1177, September 2025 Notes: epub ahead of print *- co-corresponding author.

Stevens J, Culberson E, Kinder J, Ramiriqui A, Gray J, Bonfield M, Shao TY, Al Gharaibeh F, Peterson L, Steinmeyer S, Eshleman EM, Negi S, Zacharias W, Pryhuber G, Paul O, Sengupta S, Alenghat T, Way SS, Deshmukh H.: Microbiota-derived inosine programs protective CD8+ T cell responses against influenza in newborns. Cell 188(16): 4239-4256, August 2025.

KM Forrest, M Towers, O Paul, H Cho, M.V. Padmini, A Naik, HK Lim, Y Issah, H.S Deshmukh, M.C. Abt, KM Hudock, GR. Grant, TG. Brooks, S Sengupta: Role of IL10 signaling in the circadian control of host response to Influenza infection bioRxiv. in revision at Mucosal Immunology (eds.). March 2025 Notes: https://doi.org/10.1101/2025.03.03.641134.

Sengupta S, Smith DF, Koritala BSC: Circadian Rhythms, Immune Regulation, and the Risk for Sepsis: Circadian Rhythms and Neonatal Care. Clin Perinatol 52(1): 185-197, March 2025.

Brooks TG, Lahens NF, Mrčela A, Yang J, Purohit S, Naik A, Ricciotti E, Sengupta S, Choi PS, Grant GR: Sources of non-uniform coverage in short-read RNA-Seq data. bioRxiv Feb 2025 Notes: doi: 10.1101/2025.01.30.634337.

Musa AO, Faber SR, Forrest K, Smith KP, Sengupta S, López CB: Identification of distinct genotypes in circulating RSV A strains based on variants in the virus replication-associated genes. J Virol 98(8): e0099024, Aug 2024.

Thomas Brooks , Nicholas Lahens , Antonijo Mrčela , Dimitra Sarantopoulou , Soumyashant Nayak , Amruta Naik , Shaon Sengupta , Peter Choi, G.R. Grant: BEERS2: RNA-Seq simulation through high fidelity in silico modeling. bioRxiv April 2024 Notes: doi: 10.1101/2023.04.21.537847.

Naik A, Forrest K, Paul O, Issah Y, Valekunja UK, Tang SY, Reddy AB, Hennessy E, Brooks TS, Chaudhry F, Babu A, Morley M, Zepp JA, Grant GR, FitzGerald GA, Sehgal A, Worthen GS, Frank DB, Morrisey EE, Sengupta S.: Circadian regulation of lung repair and regeneration. JCI Insight 8(16): e164720, August 2023.

Cox SL, O’Siorain JR, He Y, Lordan R, Naik A, Tang SY, Sengupta S, FitzGerald GA, Carroll RG, Curtis AM: Circadian disruption in lung fibroblasts enhances NF-κB activity to exacerbate neutrophil recruitment. FASEB J 37(2): e22753, February 2023.