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Faculty

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Max B. Kelz, MD PhD

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Lee A. Fleisher, MD Professor of Anesthesiology and Critical Care
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Department: Anesthesiology and Critical Care
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1f Graduate Group Affiliations 8 a
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46 Contact information
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3620 Hamilton Walk,
42 John Morgan Building - Room 339
Philadelphia, PA 19104
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2e Office: 215 573-8208
32 Fax: 215 349-5078
32 Lab: 215 898-8929
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Email: kelz@pennmedicine.upenn.edu
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13 Education:
21 7 MS 32 (Molecular Biophysics and Biochemistry) c
28 Yale University, 1993.
 21 7 BS 32 (Molecular Biophysics and Biochemistry) c
28 Yale University, 1993.
 21 8 PhD 19 (Neuroscience) c
28 Yale University, 1999.
 21 7 MD 15 (Medicine) c
28 Yale University, 2000.
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Links
99 Max Kelz, Department of Anesthesiology and Critical Care 38 University of Pennsylvania School of Medicine
5a Kelz lab home page
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ad NGG Home » NGG Faculty » Behavioral Neuroscience a
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Description of Research Expertise

3a Molecular Mechanisms of Anesthetic Action
2d Neurobiology of Sleep Wake Regulation
16 Mouse Genetics
19 Molecular Biology
1e Anesthetic pharmacology
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Description of Clinical Expertise

1e Anesthesiology
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Selected Publications

157 Imamura T, Wasilczuk AZ, Reitz SL, Lian J, Imamura M, Keenan BT, Shimizu N, Pack AI, Kelz MB.: Parafacial GABAergic neurone ablation induces behavioural resistance to volatile anaesthetic-induced hypnosis without reducing sleep. Br J Anaesth 134(6): 1696-1708, Jun 2025.

 149 Somnay YR, Wang A, Lim H, Griffiths KK, Zandkarimi F, Chen K, Yang G, Wasilczuk AZ, Kelz MB, Larr D, Yang M, Gil-Iturbe E, Moon A, Quick M, Levy RJ.: Effects of the quinone analog, ubiquinone-5, on murine mitochondria and hypnosis. Anesthesiology May 2025.

 10d Dávila DG, McKinstry-Wu A, Kelz MB, Proekt A.: The Administration of Ketamine Is Associated with Dose-Dependent Stabilization of Cortical Dynamics in Humans. J Neurosci 45: e1545242025, May 2025.

 dc Stone ME, Kelz MB, Proekt A, Wasilczuk AZ.: A probabilistic model of behavioural emergence from general anaesthesia in mice. Br J Anaesth Apr 2025.

 128 Cichon J, Joseph TT, Lu X, Wasilczuk AZ, Kelz MB, Mennerick SJ, Zorumski CF, Nagele P.: Nitrous oxide activates layer 5 prefrontal neurons via SK2 channel inhibition for antidepressant effect. Nat Commun 16: 2999, Apr 2025.

 10f Aggarwal A, Luo J, Chung H, Contreras D, Kelz MB, Proekt A.: Neural assemblies coordinated by cortical waves are associated with waking and hallucinatory brain states. Cell Rep 43: 114017, Apr 2024.

 12f Wasilczuk AZ, Rinehart C, Aggarwal A, Stone ME, Mashour GA, Avidan MS, Kelz MB, Proekt A; ReCCognition Study Group.: Hormonal basis of sex differences in anesthetic sensitivity. Proc Natl Acad Sci U S A 121: e2312913120, Jan 2024.

 114 McKinstry-Wu AR, Wasilczuk AZ, Dailey WP, Eckenhoff RG, Kelz MB.: In Vivo Photoadduction of Anesthetic Ligands in Mouse Brain Markedly Extends Sedation and Hypnosis. J Neurosci 43(13): 2338-48, Mar 2023.

 16b Labonte AK, Kafashan MM, Huels ER, Blain-Moraes S, Basner M, Kelz MB, Mashour GA, Avidan MS, Palanca BJ, ReCCognition Study Group: The posterior dominant rhythm: An electroencephalographic biomarker for cognitive recovery after general anaesthesia. Br J Anaesth 130(2): e233-e242, Feb 2023.

 214 Lennertz R, Pryor KO, Raz A, Parker M, Bonhomme V, Schuller P, Schneider G, Moore M, Coburn M, Root JC, Emerson JM, Hohmann AL, Azaria H, Golomb N, Defresne A, Montupil J, Pilge S, Obert DP, van Waart H, Seretny M, Rossaint R, Kowark A, Blair A, Krause B, Proekt A, Kelz M, Sleigh J, Gaskell A, Sanders RD.: Connected consciousness after tracheal intubation in young adults: an international multicentre cohort study. Br J Anaesth 130(2): e217-e224, Feb 2023.

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