Lachlan James Smith

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Associate Professor of Orthopaedic Surgery
Department: Orthopaedic Surgery

Contact information
McKay Orthopaedic Research Laboratory
378A Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104
Office: 215-746-2169
Fax: 215-573-2133
B.E. (Mechatronic Engineering)
University of Adelaide, 2001.
Ph.D. (Pathology)
University of Adelaide, 2008.
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Description of Research Expertise

The focus of my research program is the pathophysiology and treatment of degenerative and developmental disorders affecting the spine, particularly those affecting the intervertebral discs and vertebral bones. The scope of our research includes basic mechanistic studies, translational studies in animal models, and clinical studies in human patients. We use cutting edge techniques in molecular biology, biochemistry and bioengineering, coupled with novel in vitro model systems to study disease mechanisms. Our research in the translational space bridges the fields of tissue engineering, biomaterials, drug delivery and stem cells, and is focused on arresting disease progression, restoring spine function and potentiating long term tissue regeneration. We use novel, naturally occurring and inducible large and small animal models to study disease etiology and evaluate therapeutics. Our multidisciplinary team includes biologists, bioengineers, clinicians and veterinarians.

Selected Publications

Peck SH, Bendigo JR, Tobias JW, Dodge GR, Malhotra NR, Mauck RL, Smith LJ: Hypoxic preconditioning enhances bone marrow-derived mesenchymal stem cell survival in a low oxygen and nutrient-limited 3D microenvironment. Cartilage 12(4): 512-525, Oct 2021.

Peck SH, Lau YK, Kang JL, Lin M, Arginteanu T, Matalon DR, Bendigo JR, O’Donnell P, Haskins ME, Casal ML, Smith LJ : Progression of Vertebral Bone Disease in Mucopolysaccharidosis VII Dogs from Birth to Skeletal Maturity. Molecular Genetics and Metabolism 133(4): 378-385, Aug 2021.

Jiang Z, Lau YK, Wu M, Casal ML, Smith LJ: Ultrastructural Analysis of Different Skeletal Cell Types in Mucopolysaccharidosis Dogs at the Onset of Postnatal Growth. Journal of Anatomy 238(2): 416-425, Feb 2021.

Zhang C, Gullbrand SE, Schaer TP, Boorman S, Chen W, Elliott DM, Dodge GR, Mauck RL, Malhotra NR, Smith LJ: Combined Hydrogel and Mesenchymal Stem Cell Therapy for Moderate Severity Disc Degeneration in Goats. Tissue Engineering: Part A 27(1-2): 117-128, 2021.

Lau YK, Peck SH, Arginteanu T, Wu M, Lin M, Shore EM, Klein PS, Casal ML, Smith LJ: Effects of Lithium Administration on Vertebral Bone Disease in Mucopolysaccharidosis I Dogs. Bone In press, 2021.

Gawri R, Lau YK, Dodge GR, Scanzello CR, Jo S, Zhang C, Mai W, Casal ML, Smith LJ: High Dose Enzyme Replacement Therapy Attenuates Joint Disease Progression and Preserves Mobility in Mucopolysaccharidosis VII Dogs. 67th Annual Meeting, Orthopaedic Research Society, Virtual, USA 2021 Notes: Podium.

Lee NN, Salzer E, Bonilla AF, Bach FC, Cook JL, Gazit Z, Grad S, Ito K, Smith LJ, Vernengo A, Wilke HJ, Engiles JB, Tryfonidou MA: A Comprehensive Toolbox for Large Animal Studies of Intervertebral Disc Degeneration. JOR Spine In press, 2021.

Jiang Z, Johnson CJ, Nykanen O, Nissi M, Lau YK, Wu M, Casal ML, Smith LJ: Epiphyseal Cartilage Canal Architecture and Extracellular Matrix Remodeling in Mucopolysaccharidosis VII Dogs at the Onset of Postnatal Growth. Connective Tissue Research In press, 2021.

Smith LJ, Iatridis JC, Dahia CL: Advancing Basic and Preclinical Spine Research: Highlights from the Fifth ORS PSRS International Spine Research Symposium. JOR Spine In press, 2020.

Zhang C, Schaer TP, Gullbrand SE, Jiang Z, Lau YK, Elliott DM, Dodge GR, Mauck RL, Malhotra NR, Smith LJ: Inflammatory Cytokine and Catabolic Enzyme Expression in a Goat Model of Intervertebral Disc Degeneration. 66th Annual Meeting, Orthopaedic Research Society, Phoenix, USA 2020.

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Last updated: 04/13/2022
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