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Frederick S. Kaplan, M.D.
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Isaac and Rose Nassau Professor of Orthopaedic Molecular Medicine in Orthopaedic Surgery
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Department: Orthopaedic Surgery
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Contact information
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Penn Medicine University City
29 Department of Orthopaedic Surgery
40 3737 Market Street, 6th floor
Philadelphia, PA 19104
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29 Department of Orthopaedic Surgery
40 3737 Market Street, 6th floor
Philadelphia, PA 19104
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Office: 215-294-9145
32 Fax: 215-222-8854
32 Lab: 215-898-2330
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32 Fax: 215-222-8854
32 Lab: 215-898-2330
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Education:
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31 Johns Hopkins University, 1972.
21 9 M.D. c
31 Johns Hopkins University, 1976.
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Permanent link21 a B.A. c
31 Johns Hopkins University, 1972.
21 9 M.D. c
31 Johns Hopkins University, 1976.
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14e Kaplan was a Hartford Foundation Research Fellow in human genetics and molecular biology from 1989 to 1991 in the laboratory of his mentor and friend Dr. Michael Zasloff. This experience led to his exploration of the mechanisms for heterotopic bone formation and skeletal metamorphosis in several disabling childhood diseases.
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264 In 1989, Kaplan, an orthopaedic surgeon, met a child with fibrodysplasia ossificans progressiva (FOP), a rare and disabling disorder in which the body forms a second skeleton of heterotopic bone. Motivated to know and do more, Kaplan began a pioneering second career on the molecular genetics of heterotopic ossification, work that led to the discovery of the FOP gene, to the description of the molecular pathophysiology of skeletal metamorphosis in humans, to the discovery of progressive osseous heteroplasia (another disorder of heterotopic ossification) and its causative gene and pathophysiology.
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1c3 Along with his colleague Dr. Eileen Shore, Kaplan co-directs the only center in the world devoted entirely to this work, has organized the medical and scientific communities worldwide on these two rare conditions, and is recognized as the world’s leading expert on genetic disorders of heterotopic ossification and skeletal metamorphosis. In 1997, Kaplan was awarded the first endowed chair in the nation for orthopaedic molecular medicine.
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221 The late Victor McKusick, the father of clinical genetics, described Kaplan as “one of the really outstanding orthopaedic researchers of his generation. His work with FOP and POH has been extraordinary and extends all the way from the patients to the bench and back again. The devotion of the families and the patients to him is testimony to the kind of human being he is.” Cited in 2006, as one of the15 people who make America great, Newsweek noted “the disease was so rare, nobody wanted to deal with it until he came along.”
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Description of Other Expertise
1d2 Frederick S. Kaplan, M.D. is The Isaac & Rose Nassau Professor of Orthopaedic Molecular Medicine and Chief of the Division of Molecular Orthopaedic Medicine at the University of Pennsylvania School of Medicine. He is an alumnus of The Johns Hopkins University School of Medicine (1976), and was Chief Resident in Orthopaedic Surgery at The Hospital of The University of Pennsylvania and The Children’s Hospital of Philadelphia from 1980 to 1981.8
14e Kaplan was a Hartford Foundation Research Fellow in human genetics and molecular biology from 1989 to 1991 in the laboratory of his mentor and friend Dr. Michael Zasloff. This experience led to his exploration of the mechanisms for heterotopic bone formation and skeletal metamorphosis in several disabling childhood diseases.
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264 In 1989, Kaplan, an orthopaedic surgeon, met a child with fibrodysplasia ossificans progressiva (FOP), a rare and disabling disorder in which the body forms a second skeleton of heterotopic bone. Motivated to know and do more, Kaplan began a pioneering second career on the molecular genetics of heterotopic ossification, work that led to the discovery of the FOP gene, to the description of the molecular pathophysiology of skeletal metamorphosis in humans, to the discovery of progressive osseous heteroplasia (another disorder of heterotopic ossification) and its causative gene and pathophysiology.
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1c3 Along with his colleague Dr. Eileen Shore, Kaplan co-directs the only center in the world devoted entirely to this work, has organized the medical and scientific communities worldwide on these two rare conditions, and is recognized as the world’s leading expert on genetic disorders of heterotopic ossification and skeletal metamorphosis. In 1997, Kaplan was awarded the first endowed chair in the nation for orthopaedic molecular medicine.
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221 The late Victor McKusick, the father of clinical genetics, described Kaplan as “one of the really outstanding orthopaedic researchers of his generation. His work with FOP and POH has been extraordinary and extends all the way from the patients to the bench and back again. The devotion of the families and the patients to him is testimony to the kind of human being he is.” Cited in 2006, as one of the15 people who make America great, Newsweek noted “the disease was so rare, nobody wanted to deal with it until he came along.”
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107 Kaplan FS, Shore EM.: Fibrodysplasia ossificans progressiva. National Organization for Rare Disorders. https://rarediseases.org/rare-disease/fibrodysplasia-ossificans-progressiva, 2020.
f9 Pignolo RJ, Wang H, Kaplan FS. : Fibrodysplasia ossificans progressiva: a segmental progeroid syndrome. 10 1-3, 2020. Frontiers in Endocrinology 10 (Article 908): 1-3, 2020.
1fb Kou S, DeCunto C, Baujat G, Wentworth KL, Grogan DR, Brown MA, DiRocco M, Keen R, Al Mukaddam M, le Qua Sang K-H, Masharani U, Kaplan FS, Pignolo RJ, Hsiao EC.: Patients with ACVR1R206H mutations have an increased prevalence of cardiac condition abnormalities on electrocardiogram in a natural history study of fibrodysplasia ossificans progressiva. Orphanet J Rare Diseases 2020 Notes: https://doi.org/10.1186/s13023-020-01465-x.
cb Kaplan FS. Kaplan FS, Al Mukaddam M, Stanley A, Towler OW, Shore EM.: Fibrodysplasia ossificans progressiva (FOP): A disorder of osteochondrogenesis. 40 Bone 2020 Notes: [Epub ahead of print]
1ca Pignolo RJ, Cheung K. Kile S, Fitzpatrick MA, DeCunto C, Al Mukaddam M, Hsiao EC, Baujat G, Delai P, Eekhoff, EMW, DiRocco M, Grunwald Z, Haga N, Keen R, Levi B, Morhart R, Scott C, Sherman A, Zhang K, Kaplan FS. : Self-reported baseline phenotypes from the International Fibrodysplasia Ossificans Progressiva (FOP) Association global registry. Bone 2020 Notes: (Epub ahead of print).
18c Pignolo RJ, Kaplan FS. : Druggable targets, clinical trial design and proposed pharmacological management in fibrodysplasia ossificans progressiva. Expert Opinion on Orphan Drugs. p. 1-9. https://doi.org/10.1080/21678707. 2020.1751122. Expert Opinion on Orphan Drugs Page: 1-9, 2020 Notes: https://doi.org/10.1080/21678707.
f5 Kaplan FS, Al Mukaddam M, Pignolo RJ.: Compartment syndrome of the thigh in a patient with fibrodysplasia ossificans progressiva. J Ortho Case Reports 10(3): 103-107, 2020.
6d Kaplan FS, Shore EM.: Progressive osseous heteroplasia. 2 78 National Organization for Rare Disorders. https://rarediseases.org/rare-diseases/progressive-osseous-heteroplasia 1a 2020.
1e4 Cali A & Schwegler O (Executive Producers). : Tin Soldiers. Blink Films. Johannesburg, Republic of South Africa, World Premier – Johannesburg (Jozi) Film Festival; October 5, 2019. Blink Films. Johannesburg, Republic of South Africa, World Premier – Johannesburg (Jozi) Film Festival; Winner of Hollywood Independent Filmmaker Award. October 5 2019 Notes: Winner of Hollywood Independent Filmmaker Award.
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Selected Publications
e6 McCullough M.: A crippling disease called FOP is so rare it usually goes undiagnosed. A documentary may change that. Philadelphia Inquirer. February 25 2020.107 Kaplan FS, Shore EM.: Fibrodysplasia ossificans progressiva. National Organization for Rare Disorders. https://rarediseases.org/rare-disease/fibrodysplasia-ossificans-progressiva, 2020.
f9 Pignolo RJ, Wang H, Kaplan FS. : Fibrodysplasia ossificans progressiva: a segmental progeroid syndrome. 10 1-3, 2020. Frontiers in Endocrinology 10 (Article 908): 1-3, 2020.
1fb Kou S, DeCunto C, Baujat G, Wentworth KL, Grogan DR, Brown MA, DiRocco M, Keen R, Al Mukaddam M, le Qua Sang K-H, Masharani U, Kaplan FS, Pignolo RJ, Hsiao EC.: Patients with ACVR1R206H mutations have an increased prevalence of cardiac condition abnormalities on electrocardiogram in a natural history study of fibrodysplasia ossificans progressiva. Orphanet J Rare Diseases 2020 Notes: https://doi.org/10.1186/s13023-020-01465-x.
cb Kaplan FS. Kaplan FS, Al Mukaddam M, Stanley A, Towler OW, Shore EM.: Fibrodysplasia ossificans progressiva (FOP): A disorder of osteochondrogenesis. 40 Bone 2020 Notes: [Epub ahead of print]
1ca Pignolo RJ, Cheung K. Kile S, Fitzpatrick MA, DeCunto C, Al Mukaddam M, Hsiao EC, Baujat G, Delai P, Eekhoff, EMW, DiRocco M, Grunwald Z, Haga N, Keen R, Levi B, Morhart R, Scott C, Sherman A, Zhang K, Kaplan FS. : Self-reported baseline phenotypes from the International Fibrodysplasia Ossificans Progressiva (FOP) Association global registry. Bone 2020 Notes: (Epub ahead of print).
18c Pignolo RJ, Kaplan FS. : Druggable targets, clinical trial design and proposed pharmacological management in fibrodysplasia ossificans progressiva. Expert Opinion on Orphan Drugs. p. 1-9. https://doi.org/10.1080/21678707. 2020.1751122. Expert Opinion on Orphan Drugs Page: 1-9, 2020 Notes: https://doi.org/10.1080/21678707.
f5 Kaplan FS, Al Mukaddam M, Pignolo RJ.: Compartment syndrome of the thigh in a patient with fibrodysplasia ossificans progressiva. J Ortho Case Reports 10(3): 103-107, 2020.
6d Kaplan FS, Shore EM.: Progressive osseous heteroplasia. 2 78 National Organization for Rare Disorders. https://rarediseases.org/rare-diseases/progressive-osseous-heteroplasia 1a 2020.
1e4 Cali A & Schwegler O (Executive Producers). : Tin Soldiers. Blink Films. Johannesburg, Republic of South Africa, World Premier – Johannesburg (Jozi) Film Festival; October 5, 2019. Blink Films. Johannesburg, Republic of South Africa, World Premier – Johannesburg (Jozi) Film Festival; Winner of Hollywood Independent Filmmaker Award. October 5 2019 Notes: Winner of Hollywood Independent Filmmaker Award.
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