Sarah Elizabeth Gullbrand

faculty photo
Research Assistant Professor of Orthopaedic Surgery
Department: Orthopaedic Surgery

Contact information
Corporal Michael J. Crescenz VA Medical Center
3900 Woodland Ave.
Research, A214
Philadelphia, PA 19104
Office: 203-260-3089
Education:
BS (Biomedical Engineering)
Rensselaer Polytechnic Institute , 2009.
PhD (Biomedical Engineering)
Rensselaer Polytechnic Institute , 2014.
Permanent link
 
> Perelman School of Medicine   > Faculty   > Details

Description of Research Expertise

My general research interests include intervertebral disc nutrition, regenerative therapeutics for the treatment of disc degeneration, and novel non-invasive imaging modalities for the spine. As a graduate student, I was awarded a National Science Foundation Graduate Research Fellowship to pursue my thesis research on enhancing intervertebral disc nutrition as a potential therapeutic strategy for the treatment of disc degeneration. My thesis work with Dr. Eric Ledet illustrated for the first time that convective transport induced by mechanical loading can enhance the uptake and clearance of small molecules in the healthy and degenerative disc. This work was awarded the 2015 ISSLS Prize for Lumbar Spine Research in Bioengineering, the most prestigious award in the field of spine research. My postdoctoral research with Dr. Robert Mauck at the University of Pennsylvania furthered my interests in disc regeneration, and was focused on evaluating novel tissue engineered therapeutics for disc degeneration in translational animal models. This work was supported by a VA Career Development Award (CDA-1), and our publication on the long term in vivo evaluation of a tissue engineered disc replacement in Science Translational Medicine was featured by numerous news outlets including the Philadelphia Inquirer and Popular Science. In the fall of 2019, I was awarded a VA RR&D CDA-2 to study the contribution of vertebral endplate remodeling and altered disc nutrition on the progression of disc degeneration, and the role of disc nutrition in the non-operative treatment of patients with back pain.

Selected Publications

Matthew Fainor; Sonal Mahindroo; Sachin Gupta; Robert L. Mauck; Harvey E. Smith; Sarah E. Gullbrand: Intervertebral Disc And Facet Cross-Talk In A Rabbit Puncture Model Of Spine Degeneration. Proceedings of the Annual Meeting of the Orthopaedic Research Society 2022.

Matthew Fainor; Kerri R. Betz; Sonal Mahindroo; Ryan C. Locke; Harvey E. Smith; Robert L. Mauck; Sarah E. Gullbrand: The Effects Of Hydroxyapatite Coating On Poly(caprolactone) Micromechanics And Mesenchymal Stem Cell Behavior. Proceedings of the Annual Meeting of the Orthopaedic Research Society 2022.

Hannah M. Zlotnick; Tala Azar; Sung Yeon Kim; Sienna C. Pyle; Elisabeth A. Lemmon; Ana P. Peredo; Catherine A. Bautista; Matthew Fainor; Robert L. Mauck; John F. Drazan; Brittany L. Taylor; Joel D. Boerckel; Eileen M. Shore; Sarah E. Gullbrand: Reimagining Conferences As Platforms To Provide Early Research Exposure And Networking To Diverse Undergraduates. Proceedings of the Annual Meeting of the Orthopaedic Research Society 2022.

Lance Murphy; Ana Peredo; Sarah Gullbrand; Robert Mauck: Interleukin-1β As A Neuroinflammatory Mediator In Intervertebral Disc Injury. Proceedings of the Annual Meeting of the Orthopaedic Research Society 2022.

Sarah E. Gullbrand; Sonal Mahindroo; Matthew Fainor; Kyle Meadows; Adriana Barba; Klaus Hopster; Thomas P. Schaer; Dawn M. Elliott; Robert L. Mauck; Harvey E. Smith: A Large Animal Model Of Motion Segment Degeneration For Evaluation Of Engineered Disc Replacements. Proceedings of the Annual Meeting of the Orthopaedic Research Society 2022.

Ana P. Peredo; Snehal S. Shetye; Chet S. Friday; Hannah M. Zlotnick; Lance A. Murphy; Brendan D. Stoeckl; George R. Dodge; Daeyeon Lee; Michael W. Hast; Sarah E. Gullbrand; Harvey E. Smith; Robert L. Mauck: A Mechano-Responsive Annular Repair Device For Biologics Delivery In The Goat Cervical Spine. Proceedings of the Annual Meeting of the Orthopaedic Research Society 2022.

Anna N. Smith; Ana Peredo; Richa Gupta; Robert Mauck; Sarah Gullbrand; Michael Hast: Development Of 3D Printed Biodegradable PLGA Implants To Control Loading During Fracture Repair. Proceedings of the Annual Meeting of the Orthopaedic Research Society 2022.

Taimoor H. Qazi,Jingyu Wu,Victoria G. Muir,Shoshana Weintraub,Sarah E. Gullbrand,Daeyeon Lee,David Issadore,Jason A. Burdick : Anisotropic Rod-Shaped Particles Influence Injectable Granular Hydrogel Properties and Cell Invasion. Advanced Materials Page: 2109194, 2021.

Sarah E. Gullbrand, Beth G. Ashinsky, Sai Mandalapu, Kamiel Saleh, Robert L. Mauck, Harvey E. Smith: Hydroxyapatite Coating Of Porous Polycaprolactone To Enhance Integration Of A Tissue-Engineered Total Disc Replacement. Proceedings of the Annual Meeting of the Orthopaedic Research Society 2021.

Nicolette Driscoll, Brian Erickson, Brendan B Murphy, Andrew G Richardson, Gregory Robbins, Nicholas V Apollo, Georgios Mentzelopoulos, Tyler Mathis, Kanit Hantanasirisakul, Puneet Bagga, Sarah E Gullbrand, Matthew Sergison, Ravinder Reddy, John A Wolf, H Isaac Chen, Timothy H Lucas, Timothy R Dillingham, Kathryn A Davis, Yury Gogotsi, John D Medaglia, Flavia Vitale: MXene-infused bioelectronic interfaces for multiscale electrophysiology and stimulation. Science Translational Medicine 13(612): eabf8629, 2021.

back to top
Last updated: 04/19/2022
The Trustees of the University of Pennsylvania
 
Back to Top