Nathaniel Dyment

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Assistant Professor of Orthopaedic Surgery
Department: Orthopaedic Surgery

Contact information
McKay Orthopaedic Research Laboratory
330A Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104-6081
Office: 215-746-8138
Fax: 215-573-2133
Lab: 215-746-8167
Education:
B.S. (Materials Science and Engineering)
University of Illinois at Urbana-Champaign , 2005.
Ph.D. (Biomedical Engineering)
University of Cincinnati, 2011.
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Description of Research Expertise

My primary research goals are directed towards understanding the genetic, cellular, and mechanical mechanisms that regulate normal development, disease (e.g., chronic tendon pathologies, osteoarthritis, psoriatic arthritis, ankylosing spondylitis), and repair of tissues in the joint. My current research focuses on 1) identifying the resident progenitor populations that contribute to normal growth, healing and repair, 2) characterizing the mechanisms that control the expansion and differentiation of these cells, and 3) ascertaining the phenotypical markers that define the stages of differentiation from early stem/progenitors to mature tendon/ligament fibroblasts and chondrocytes. These goals in combination will guide future therapeutic strategies and provide success criteria to assess efficacy moving forward.

Selected Publications

Tyler Blanch, Yujia Zhang, Xi Jiang, Zizhao Li, Nathaniel A. Dyment, Su-Jin Heo: Age-Dependent Inflammatory Responsiveness and Chromatin Dynamics in Mouse Tenocytes. Orthopaedic Research Society Annual Meeting February 2024.

Talayah Johnson, Natalie L. Fogarty, Bryan Kwok, Alisia Lin, Tonia K. Tsinman, Xi Jiang, Eiki Koyama, Lin Han, Josh R. Baxter, Robert L. Mauck, Nathaniel A. Dyment: Reduced Postnatal Loading After Sciatic Nerve Resection Impairs Achilles Tendon Growth And Maturation. Orthopaedic Research Society Annual Meeting February 2024.

Eric Gutierrez, Camila Reyes, Talayah Johnson, Nathan WC Campbell, Johnny M. Vanos, Zain A. Loges, Nathaniel Dyment, Chad C Carrol: Impact Of Rage Inhibitor Administration On Tendon Biomechanical Properties In A Mouse Model Of Type 2 Diabetes. Orthopaedic Research Society Annual Meeting February 2024.

Nat A. Thurlow, Jeremy D. Eekhoff, Ashley K. Fung, Courtney A. Nuss, Stephanie N. Weiss, Nathaniel A. Dyment, Louis J. Soslowsky: Collagens V and XI Jointly Regulate Fibril Assembly and Elastic Mechanical Properties during Tendon Maturation. Orthopaedic Research Society Annual Meeting February 2024.

Catherine A. Bautista, Courtney A. Nuss, Louis J. Soslowsky, Nathaniel A. Dyment: Tendon Resident Macrophages Are Dependent On Fibroblast-derived Csf1 And Are Essential For Normal Collagen Fibrillogenesis. Orthopaedic Research Society Annual Meeting February 2024.

Jun Li, Tao Gui, Lutian Yao, Hanli Guo, Yu-Lieh Lin, Jiawei Lu, Michael Duffy, Miltiadis Zgonis, Robert Mauck, Nathaniel Dyment, Yejia Zhang, Carla Scanzello, Patrick Seale, Ling Qin: Synovium And Joint Fat Pad Share Common Mesenchymal Progenitors And Undergo Coordinated Changes In Osteoarthritis. Orthopaedic Research Society Annual Meeting February 2024.

Harrison Cottingham, Camila Reyes, Nathan WC. Campbell, Talayah Johnson, Johnny M. Vanos, Zain A. Loges, Nathaniel Dyment, and Chad C. Carroll: Impact Of Serum Advanced Glycation End-products And Rage Inhibitor Administration On Patellar Tendon Healing In A Mouse Model. Orthopaedic Research Society Annual Meeting February 2024.

Rashad Madi, Jonathan Marcelin, Timur B. Kamalitdinov, Xi Jiang, Sereen Assi, Dong-Hwa Kim, Robert L Mauck, Andrew F. Kuntz, Nathaniel A. Dyment: Localized Delivery Of A Hedgehog Agonist From Electrospun Scaffolds Enhances Tendon-to-bone Integration. Orthopaedic Research Society Annual Meeting February 2024.

Thomas P. Leahy, Srish S. Chenna, Louis J. Soslowsky, Nathaniel A. Dyment: Focal Adhesion Kinase Regulates Physiological Tendon Development and Growth. Orthopaedic Research Society Annual Meeting February 2024.

Bryan Kwok, Mingyue Fan, Jiaqi Xiang, Aanya Mohan, Michael Newton, Yuchen Liu, David E. Birk, Eiki Koyama, Nathaniel A. Dyment, Robert L. Mauck, Tristan Maerz, Lin Han: Type V Collagen Is Essential For The Initial Matrix Templating Of Articular Cartilage And The Meniscus. Orthopaedic Research Society Annual Meeting February 2024.

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Last updated: 02/24/2024
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