Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory

Faculty

Nathaniel Dyment

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Assistant Professor of Orthopaedic Surgery
Department: Orthopaedic Surgery

Contact information
McKay Orthopaedic Research Laboratory
109A Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104-6081
Office: 215-746-8138
Fax: 215-573-2133
Lab: 215-746-8167
Education:
B.S. (Materials Science and Engineering)
University of Illinois at Urbana-Champaign , 2005.
Ph.D. (Biomedical Engineering)
University of Cincinnati, 2011.
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Description of Research Expertise

My primary research goals are directed towards understanding the genetic, cellular, and mechanical mechanisms that regulate normal development, disease (e.g., chronic tendon pathologies, osteoarthritis, psoriatic arthritis, ankylosing spondylitis), and repair of tissues in the joint. My current research focuses on 1) identifying the resident progenitor populations that contribute to normal growth, healing and repair, 2) characterizing the mechanisms that control the expansion and differentiation of these cells, and 3) ascertaining the phenotypical markers that define the stages of differentiation from early stem/progenitors to mature tendon/ligament fibroblasts and chondrocytes. These goals in combination will guide future therapeutic strategies and provide success criteria to assess efficacy moving forward.

Selected Publications

Vidovic, I, Banerjee, A, Fatahi, R, Matthews, BG, Dyment, NA, Kalajzic, I, Mina, M: alpha SMA-Expressing Perivascular Cells Represent Dental Pulp Progenitors In Vivo. journal of dental research 96(3): 323-330, MAR 2017.

Decker RS, Um HB, Dyment NA, Cottingham N, Usami Y, Enomoto-Iwamoto M, Kronenberg MS, Maye P, Rowe DW, Koyama E, Pacifici M.: Cell origin, volume and arrangement are drivers of articular cartilage formation, morphogenesis and response to injury in mouse limbs. Dev Biol 426(1): 56-68, 2017.

Smilowitz HM, Tarmu LJ, Sanders MM, Taylor JA 3rd, Choudhary D, Xue C, Dyment NA, Sasso D, Deng X, Hainfeld JF: Biodistribution of gold nanoparticles in BBN-induced muscle-invasive bladder cancer in mice. Int J Nanomedicine 12: 7937-7946, 2017.

Dyrna F, Pauzenberger L, Zakko P, McCarthy M, Rowe DW, Mazzocca AD, Dyment NA: Comparison of Human Cell Populations on Tendon Repair. Summer Biomechanics, Bioengineering and Biotransport Conference 2017.

Dyrna F, Pauzenberger L, Zakko P, McCarthy M, Rowe DW, Mazzocca AD, Dyment NA: Human subacromial bursa cells display superior engraftment vs. bone marrow stromal cells in murine tendon repair. Orthopaedic Research Society Conference 2017.

Arble Jessica R, Lalley Andrea L, Dyment Nathaniel A, Joshi Pujan, Shin Dong-Guk, Gooch Cynthia, Grawe Brian, Rowe David, Shearn Jason T: The LG/J Murine Strain Exhibits Near-Normal Tendon Biomechanical Properties Following a Full-Length Central Patellar Tendon Defect. Connective tissue research 23, Aug 2016 Notes: Epub Ahead of Print.

Matic Igor, Matthews Brya G, Wang Xi, Dyment Nathaniel A, Worthley Daniel L, Rowe David W, Grcevic Danka, Kalajzic Ivo: Quiescent bone lining cells are a major source of osteoblasts during adulthood. Stem cells (Dayton, Ohio) Aug 2016 Notes: Epub Ahead of Print.

Zhang, J, Siu, S, Dyment, NA, Rowe, DW, Sundberg, JP, Uitto, J, Li, Q: Ectopic mineralization and altered bone development in Enpp1asj-2J mice. journal of investigative dermatology 136(5 1): S68, MAY 2016.

Yoshida Ryu, Alaee Farhang, Dyrna Felix, Kronenberg Mark S, Maye Peter, Kalajzic Ivo, Rowe David W, Mazzocca Augustus D, Dyment Nathaniel A: Murine supraspinatus tendon injury model to identify the cellular origins of rotator cuff healing. Connective tissue research 16: 1-9, May 2016 Notes: Epub Ahead of Print.

Decker, RS, Um, HB, Dyment, NA, Cottingham, N, Koyama, E, Kronenberg, M, Maye, P, Rowe, DW, Pacifici, M: SPECIFIC SYNOVIAL JOINT PROGENITOR CELL POPULATIONS UNIQUELY CONTRIBUTE TO ARTICULAR CARTILAGE GROWTH AND REPAIR. osteoarthritis and cartilage 24(S): S16, APR 2016.

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Last updated: 01/11/2018
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