Nathaniel Dyment, PhD

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Assistant Professor of Orthopaedic Surgery
Department: Orthopaedic Surgery

Contact information
McKay Orthopaedic Research Laboratory
330A Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104-6081
Office: 215-746-8138
Fax: 215-573-2133
Lab: 215-746-8167
Education:
B.S. (Materials Science and Engineering)
University of Illinois at Urbana-Champaign , 2005.
Ph.D. (Biomedical Engineering)
University of Cincinnati, 2011.
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Description of Research Expertise

My lab’s primary research goals are directed towards understanding the genetic, cellular, and mechanical mechanisms that regulate normal development, disease, and repair of dense connective tissues. I am particularly interested in identifying markers that define resident progenitors vs. mature cell types and the environmental cues (molecular and mechanical) that regulate their differentiation. I was awarded a K99/R00 grant in 2015 to define the tendon cell lineage and pathways that regulate tenogenesis, which led to our current work investigating the role of hedgehog signaling in tendon-to-bone repair and developing novel drug delivery systems targeting this pathway to improve repair outcomes. My lab also examines how mechanical forces impact the formation and maintenance of dense connective tissues. Ultimately, the long-term goals of my lab are directed towards translating these mechanistic studies to novel therapeutic strategies.

Selected Publications

J. Marcelin, R. Madi, T. Kamalitdinov, X. Jiang, D-H. Kim, R. L. Mauck, A. Kuntz, N. Dyment: Tailored delivery of a small molecule agonist for hedgehog signaling activation in tendon-to-bone integration Summer Biomechanics, Bioengineering and Biotransport Conference June 2024.

Meghan E. Kupratis, Yuqi Zhang, Jiaqi Xiang, Bryan Kwok, Elisabeth A. Lemmon, Nathaniel A. Dyment, Lin Han, Eiki Koyama, Robert L. Mauck: Micromechanics and mechanoresponsivity of the developing porcine meniscus. Summer Biomechanics, Bioengineering and Biotransport Conference June 2024.

J. Xiang, B. Kwok, M. Fan, M. E. Kupratis, S. Tufa, D. R. Keene, R. L. Mauck, N.A. Dyment, E. Koyama, L. Han: Distinct molecular and structural traits of permanent versus transient cartilage in early development. Summer Biomechanics, Bioengineering, and Biotransport Conference June 2024.

Mary Kate Evans, Ellie Bernstein, Tonia K. Tsinman, Ellie J. Ferguson, Xi Jiang, Joel D. Boerckel, Lin Han, Eiki Koyama, Robert L. Mauck, Nathaniel A. Dyment: Scleraxis-targeted deletion of non-muscle myosin leads to tendon degeneration Summer Biomechanics, Bioengineering and Biotransport Conference June 2024.

Talayah A. Johnson, Natalie Fogarty, Alisia Lin, Tonia K. Tsinman, Xi Jiang, Eiki Koyama, Lin Han, Josh R. Baxter, Joel D. Boerckel, Robert L. Mauck, Nathaniel A. Dyment: Reduced loading after sciatic nerve resection impairs hindlimb growth and maturation. Summer Biomechanics, Bioengineering and Biotransport Conference June 2024.

Koo BH, Lee YJ, Park NR, Heo SC, Hudson DM, Fernandes AA, Friday CS, Hast MW, Corr DT, Keene DR, Tufa SF, Dyment NA, Joeng KS.: Characterization of TGFβ1-induced tendon-like structure in the scaffold-free three-dimensional tendon cell culture system. Sci Rep 14: 9495, Apr 2024.

Li J, Gui T, Yao L, Guo H, Lin YL, Lu J, Duffy M, Zgonis M, Mauck R, Dyment N, Zhang Y, Scanzello C, Seale P, Qin L.: Synovium and infrapatellar fat pad share common mesenchymal progenitors and undergo coordinated changes in osteoarthritis. J Bone Miner Res 39: 161-176, Mar 2024.

Tyler Blanch, Yujia Zhang, Xi Jiang, Zizhao Li, Nathaniel A. Dyment, Su-Jin Heo: Age-Dependent Inflammatory Responsiveness and Chromatin Dynamics in Mouse Tenocytes. Orthopaedic Research Society Annual Meeting February 2024.

Thomas P. Leahy, Srish S. Chenna, Louis J. Soslowsky, Nathaniel A. Dyment: Focal Adhesion Kinase Regulates Physiological Tendon Development and Growth. Orthopaedic Research Society Annual Meeting February 2024.

Bryan Kwok, Mingyue Fan, Jiaqi Xiang, Aanya Mohan, Michael Newton, Yuchen Liu, David E. Birk, Eiki Koyama, Nathaniel A. Dyment, Robert L. Mauck, Tristan Maerz, Lin Han: Type V Collagen Is Essential For The Initial Matrix Templating Of Articular Cartilage And The Meniscus. Orthopaedic Research Society Annual Meeting February 2024.

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Last updated: 05/29/2024
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