Nathaniel Dyment

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Assistant Professor of Orthopaedic Surgery
Department: Orthopaedic Surgery

Contact information
McKay Orthopaedic Research Laboratory
330A Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104-6081
Office: 215-746-8138
Fax: 215-573-2133
Lab: 215-746-8167
B.S. (Materials Science and Engineering)
University of Illinois at Urbana-Champaign , 2005.
Ph.D. (Biomedical Engineering)
University of Cincinnati, 2011.
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Description of Research Expertise

My primary research goals are directed towards understanding the genetic, cellular, and mechanical mechanisms that regulate normal development, disease (e.g., chronic tendon pathologies, osteoarthritis, psoriatic arthritis, ankylosing spondylitis), and repair of tissues in the joint. My current research focuses on 1) identifying the resident progenitor populations that contribute to normal growth, healing and repair, 2) characterizing the mechanisms that control the expansion and differentiation of these cells, and 3) ascertaining the phenotypical markers that define the stages of differentiation from early stem/progenitors to mature tendon/ligament fibroblasts and chondrocytes. These goals in combination will guide future therapeutic strategies and provide success criteria to assess efficacy moving forward.

Selected Publications

Chandrasekaran P, Kwok B, Han B, Adams SM, Wang C, Chery DR, Mauck RL, Dyment NA, Lu XL, Frank DB, Koyama E, Birk DE, Han L.: Type V Collagen Regulates the Structure and Biomechanics of TMJ Condylar Cartilage: A Fibrous-Hyaline Hybrid. Matrix Biol Jul 2021.

Tsinman TK, Jiang X, Han L, Koyama E, Mauck RL, Dyment NA: Intrinsic and growth-mediated cell and matrix specialization during murine meniscus tissue assembly. FASEB J accepted, July 2021.

Wei Y, Sun H, Gui T, Yao L, Zhong L, Yu W, Heo SJ, Han L, Dyment NA, Liu XS, Zhang Y, Koyama E, Long F, Zgonis MH, Mauck RL, Ahn J, Qin L.: The critical role of Hedgehog-responsive mesenchymal progenitors in meniscus development and injury repair. Elife 10: e62917, Jun 2021.

Park NR, Shetye SS, Bogush I, Keene DR, Tufa S, Hudson DM, Archer M, Qin L, Soslowsky LJ, Dyment NA, Joeng KS.: Reticulocalbin 3 is involved in postnatal tendon development by regulating collagen fibrillogenesis and cellular maturation. Sci Rep 11: 10868, May 2021.

Cosgrove BD, Loebel C, Driscoll TP, Tsinman TK, Dai EN, Heo SJ, Dyment NA, Burdick JA, Mauck RL.: Nuclear envelope wrinkling predicts mesenchymal progenitor cell mechano-response in 2D and 3D microenvironments. Biomaterials 270: 120662, Mar 2021.

Yu W, Zhong L, Yao L, Wei Y, Gui T, Li Z, Kim H, Holdreith N, Jiang X, Tong W, Dyment NA, Liu XS, Yang S, Choi Y, Ahn J, Qin L: Bone marrow adipogenic lineage precursors promote osteoclastogenesis in bone remodeling and pathologic bone loss. J Clin Invest January 2021.

Ashley K. Fung; Nathaniel A. Dyment; David E. Birk; Louis J. Soslowsky: Collagen XII Regulates Tendon Dynamic Mechanical Properties And Collagen Fiber Realignment. Orthopaedic Research Society Annual Meeting 2021.

Catherine A. Bautista; Mary Kate Evans; Tonia K. Tsinman; Nathaniel A. Dyment: Tendon Resident Macrophages Internalize Type 1 Collagen And Express Trophic Signaling Factors. Orthopaedic Research Society Annual Meeting 2021.

Yeonju Lee; Na Rae Park; Nathaniel A Dyment; Kyu Sang Joeng: Scaffold-free 3D Tendon Cell Culture Using Mouse Tendon Cells. Orthopaedic Research Society Annual Meeting 2021.

Ryan J Leiphart, Stephanie N Weiss, Louis J Soslowsky, Nathaniel A Dyment: Collagen V Knockdown in Mature Murine Tendons Causes Sex-Dependent Expression Changes. Orthopaedic Research Society Annual Meeting 2021.

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Last updated: 08/13/2021
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