Nathaniel Dyment

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Assistant Professor of Orthopaedic Surgery
Department: Orthopaedic Surgery

Contact information
McKay Orthopaedic Research Laboratory
330A Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104-6081
Office: 215-746-8138
Fax: 215-573-2133
Lab: 215-746-8167
Education:
B.S. (Materials Science and Engineering)
University of Illinois at Urbana-Champaign , 2005.
Ph.D. (Biomedical Engineering)
University of Cincinnati, 2011.
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Description of Research Expertise

My primary research goals are directed towards understanding the genetic, cellular, and mechanical mechanisms that regulate normal development, disease (e.g., chronic tendon pathologies, osteoarthritis, psoriatic arthritis, ankylosing spondylitis), and repair of tissues in the joint. My current research focuses on 1) identifying the resident progenitor populations that contribute to normal growth, healing and repair, 2) characterizing the mechanisms that control the expansion and differentiation of these cells, and 3) ascertaining the phenotypical markers that define the stages of differentiation from early stem/progenitors to mature tendon/ligament fibroblasts and chondrocytes. These goals in combination will guide future therapeutic strategies and provide success criteria to assess efficacy moving forward.

Selected Publications

Yilu Zhou, Yihan Li, Zachary Davis, Wenzheng Wang, Justin B. Leggin, Ashley K. Fung, Snehal S. Shetye, Xi Jiang, Andrew F. Kuntz, Nathaniel Dyment, Lou J. Soslowsky, X. Sherry Liu: Adaptive Response To Pregnancy And Lactation Optimizes The Balance Between Calcium Homeostasis And Mechanical Integrity Of The Maternal Humerus Bone And Supraspinatus Tendon Enthesis. Orthopaedic Research Society Annual Meeting February 2022.

Prashant Chandrasekaran, Abdulaziz Alanazi, Bryan Kwok, Qing Li, Girish Viraraghavan, Sriram Balasubramanian, David B. Frank, Robert L. Mauck, Nathaniel A. Dyment, Eiki Koyama, Lin Han: Distinct Roles Of Collagen V In TMJ Articular Disc Versus Condylar Cartilage During Joint Growth And Remodeling. Orthopaedic Research Society Annual Meeting February 2022.

Saeed B. Ahmed, Yujia Zhang, Ryan Daniels, Catherine Bautista, Lena Hamvas, Xi Jiang, Zizhao Li, Melike Lakadamyali, Nathaniel A. Dyment, Robert L. Mauck, and Su-Jin Heo: Aging alters Epigenetic and Mechanobiological Status in Murine Tenocyte. Orthopaedic Research Society Annual Meeting February 2022.

Ashley K. Fung, Thomas P. Leahy, Stephanie N. Weiss, Sheila M. Adams, Nathaniel A. Dyment, David E. Birk, Louis J. Soslowsky: Knockdown Of Decorin And Biglycan At Time Of Tendon Injury Alters Gene Expression And Fibril Morphology. Orthopaedic Research Society Annual Meeting February 2022.

Madhura P. Nijsure, Miriam Baitner, Yasaman Moharrer, Dakota Jones, Annapurna Pranatharthi-Haran, Greg Szeto, Nathaniel Dyment, Joel D. Boerckel: Yap-mediated Transcriptional Regulation Of Periosteal Progenitor Activation. Orthopaedic Research Society Annual Meeting February 2022.

Matthew Stein, Snehal Shetye, Courtney Nuss, Ashley Fung, Jaclyn Carlson, Stephanie Weiss, Jordan Cohen, Nathaniel Dyment, Louis J. Soslowsky: Scleraxis Targeted Deletion Of Collagen XI Disrupts Mouse Patellar Tendon Structure During Postnatal Development. Orthopaedic Research Society Annual Meeting February 2022.

Ryan J Leiphart, Stephanie N Weiss, Nathaniel A Dyment, Louis J Soslowsky: Regional FDL Tendon Development Involves Differential Pericellular Matrix Expression And Presence. Orthopaedic Research Society Annual Meeting February 2022.

Yeonju Lee, Na Rae Park, Nathaniel A. Dyment, Kyu Sang Joeng: MTORC1 Signaling Initiate Early Differentiation And Enhance Tenocyte Maturation In Tendon. Orthopaedic Research Society Annual Meeting February 2022.

Catherine Bautista, Nathaniel Dyment: Phenotypic Profiling And Spatial Localization Of Resident Tendon Macrophages. Orthopaedic Research Society Annual Meeting February 2022.

Tala Azar, Kruti Desai, Justin Leggin, Wenzheng Wang, Nathaniel Dyment, X. Sherry Liu: Dynamics Of New Bone Formation In A Cyclic Treatment Regimen Of Parathyroid Hormone-related Peptide (PTHrP). Orthopaedic Research Society Annual Meeting February 2022.

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Last updated: 01/06/2022
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