Nathaniel Dyment

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Assistant Professor of Orthopaedic Surgery
Department: Orthopaedic Surgery

Contact information
McKay Orthopaedic Research Laboratory
330A Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104-6081
Office: 215-746-8138
Fax: 215-573-2133
Lab: 215-746-8167
B.S. (Materials Science and Engineering)
University of Illinois at Urbana-Champaign , 2005.
Ph.D. (Biomedical Engineering)
University of Cincinnati, 2011.
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Description of Research Expertise

My primary research goals are directed towards understanding the genetic, cellular, and mechanical mechanisms that regulate normal development, disease (e.g., chronic tendon pathologies, osteoarthritis, psoriatic arthritis, ankylosing spondylitis), and repair of tissues in the joint. My current research focuses on 1) identifying the resident progenitor populations that contribute to normal growth, healing and repair, 2) characterizing the mechanisms that control the expansion and differentiation of these cells, and 3) ascertaining the phenotypical markers that define the stages of differentiation from early stem/progenitors to mature tendon/ligament fibroblasts and chondrocytes. These goals in combination will guide future therapeutic strategies and provide success criteria to assess efficacy moving forward.

Selected Publications

Timur B. Kamalitdinov, Keitaro Fujino, Yaping Ye, Xi Jiang, Snehal S. Shetye, Ashley B. Rodriguez, Andrew F. Kuntz, Miltiadis H. Zgonis, Nathaniel A. Dyment: Alpha smooth muscle actin-expressing bone marrow progenitor cells contribute to tunnel integration following ACL reconstruction. Summer Biomechanics, Bioengineering and Biotransport Conference June 2019.

Kamalitdinov Timur B, Fujino Keitaro, Shetye Snehal S, Jiang Xi, Ye Yaping, Rodriguez Ashley B, Kuntz Andrew F, Zgonis Miltiadis H, Dyment Nathaniel A: Amplifying Bone Marrow Progenitors Expressing α-Smooth Muscle Actin Produce Zonal Insertion Sites During Tendon-to-Bone Repair. J Orthop Res Jun 2019.

CA Bautista, X Jiang, NA Dyment: Unique Subpopulation of Col1a1CFP Negative Tenocytes that Exhibit MMP Activity. Orthopaedic Research Society Annual Meeting February 2019.

Joseph M. Collins, Xi Jiang, Tonia Tsinman, Nathaniel Dyment, Joel D. Boerckel: YAP and TAZ regulate the formation of the primary ossification center in embryonic limbs. Orthopaedic Research Society Annual Meeting February 2019.

Tonia K. Tsinman, Chao Wang, Xi Jiang, Eiki Koyama, Lin Han, Robert L. Mauck, Nathaniel A. Dyment: Temporal evolution of cell phenotype and biophysical cues in the developing murine meniscus microenvironment. Orthopaedic Research Society Annual Meeting February 2019.

Snehal S. Shetye, Yusuke Hagiwara, Ashley B. Rodriguez, Miltiadis H. Zgonis, Andrew F. Kuntz, Nathaniel A. Dyment: Anterior Drawer Tests to Quantify the Stability of the Murine Knee. Orthopaedic Research Society Annual Meeting February 2019.

Dyrna Felix, Zakko Philip, Pauzenberger Leo, McCarthy Mary Beth, Mazzocca Augustus D, Dyment Nathaniel A: Human Subacromial Bursal Cells Display Superior Engraftment Versus Bone Marrow Stromal Cells in Murine Tendon Repair. The American journal of sports medicine 46(14): 3511-3520, Dec 2018.

X Jiang, C Thompson, N Oyster, NA Dyment: Collagen GFP reporter mice reveal unique subsets of cells within tendon midsubstance Musculoskeletal Biology and Bioengineering Gordon Research Conference August 2018.

X Jiang, C Thompson, N Oyster, NA Dyment: Collagen GFP reporter mice reveal unique subsets of cells within tendon midsubstance. Orthopaedic Research Society Conference March 2018.

TK Tsinman, X Jiang, RL Mauck, NA Dyment: Single cell imaging of Col1/Col2 fluorescent reporters in the murine meniscus reveals marked spatial heterogeneity. Orthopaedic Research Society Conference 2018.

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Last updated: 10/07/2019
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