Nathaniel Dyment

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Assistant Professor of Orthopaedic Surgery
Department: Orthopaedic Surgery

Contact information
McKay Orthopaedic Research Laboratory
330A Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104-6081
Office: 215-746-8138
Fax: 215-573-2133
Lab: 215-746-8167
Education:
B.S. (Materials Science and Engineering)
University of Illinois at Urbana-Champaign , 2005.
Ph.D. (Biomedical Engineering)
University of Cincinnati, 2011.
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Description of Research Expertise

My primary research goals are directed towards understanding the genetic, cellular, and mechanical mechanisms that regulate normal development, disease (e.g., chronic tendon pathologies, osteoarthritis, psoriatic arthritis, ankylosing spondylitis), and repair of tissues in the joint. My current research focuses on 1) identifying the resident progenitor populations that contribute to normal growth, healing and repair, 2) characterizing the mechanisms that control the expansion and differentiation of these cells, and 3) ascertaining the phenotypical markers that define the stages of differentiation from early stem/progenitors to mature tendon/ligament fibroblasts and chondrocytes. These goals in combination will guide future therapeutic strategies and provide success criteria to assess efficacy moving forward.

Selected Publications

Williams D, Xiao L, Dyment NA, Hurley M: Role of FGF Receptor, FGF23 Signaling in Enthesopathy of Achilles Tendon in High Molecular Weight FGF2 Transgenic Mice. American Society for Bone and Mineral Research Annual Meeting September 2020.

Tseng W, Wang W, Zhao H, Bennett A, Mariani L, Li Y, Azar T, Dyment NA, Kim D, Turner K, Liu X: Differences in Material Properties of Trabecular Bone Tissue from Modeling- and Remodeling-Based Bone Formation in Rats. American Society for Bone and Mineral Research Annual Meeting September 2020.

Azar T, Wang W, Tseng W, Zhao H, Dyment N, Liu X: Greater Activation of Modeling-Based Bone Formation and Improvement in Bone Microarchitecture by Intermittent PTHrP vs. PTH in Ovariectomized (OVX) Rats. American Society for Bone and Mineral Research Annual Meeting September 2020.

Wang W, Tseng W, Zhao H, Azar T, Dyment NA, Liu X: Dynamics of Modeling- and Remodeling-Based Bone Formation in Response to Intermittent Parathyroid Hormone (PTH) Treatment and Discontinuation. American Society for Bone and Mineral Research Annual Meeting September 2020.

Kamalitdinov TB, Fujino K, Jiang X, Kuntz AF, Zgonis MH, Dyment NA: Hedgehog signaling promotes tendon-to-bone integration. Summer Biomechanics, Bioengineering, and Biotransport Conference June 2020.

Kwok B, Chandrasekaran P, Wang C, Han B, Koyama E, Dyment NA, Mauck RL, Han L: Nanomechanical signatures of developing intercellular matrix in embryonic cartilage and meniscus. Summer Biomechanics, Bioengineering, and Biotransport Conference June 2020.

Collins J, Dyment NA, Boerckel J: YAP and TAZ Mediate Mechanical Regulation of Embryonic Bone Development. Summer Biomechanics, Bioengineering, and Biotransport Conference June 2020.

Xi Jiang; Catherine Bautista; Anjana Srikumar; Andrew Hendrix; Courtney Thompson; Alexander Kuang; Andrew Kim; Nathaniel Dyment: Collagen And Prg4 Fluorescent Reporter Mice Establish Unique Subsets Of Tendon Fibroblasts. Orthopaedic Research Society Annual Meeting February 2020.

Catherine A. Bautista; Xi Jiang; Kyu Sang Joeng; Nathaniel A. Dyment: F4/80 Tendon Resident Macrophages And Potential Cross-talk With Tendon Fibroblasts During Growth. Orthopaedic Research Society Annual Meeting February 2020.

Timur B. Kamalitdinov; Keitaro Fujino; Xi Jiang; Andrew F. Kuntz; Miltiadis H. Zgonis; Nathaniel A. Dyment: Hedgehog Signaling Regulates Tunnel Integration Following ACL Reconstruction. Orthopaedic Research Society Annual Meeting February 2020.

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Last updated: 08/05/2020
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