Kyu Sang Joeng
331A Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104
Yonsei University, 2001.
Yonsei University, 2003.
Ph.D. (Developmental Biology)
Washington University, 2010.
Description of Research ExpertiseResearch Interest
The function of molecular and genetic signaling pathways involved in the development of musculoskeletal tissues.
Development, Regeneration, Genetics, Mouse, Signaling, Bone, Tendon, Cartilage
My laboratory is interested in signaling pathways regulating development and homeostasis of musculoskeletal system. We use moues genetic models to study the function of ER stress, mTORC1, and Wnt signaling in bone, cartilage and tendon. I am also interested in the involvement of these signaling pathways in injury repair. Recent studies showed that developmental signaling pathways are involved in injury repair of musculoskeletal tissue. My laboratory combines several surgery models with mouse genetic models to investigate the function of signaling pathways in injury repair mechanism. Furthermore, my laboratory also studies the contribution of abnormal signaling pathways to the pathogenic mechanism of musculoskeletal diseases such as osteoarthritis, osteoporosis, and tendinopathy. I expect that my research programs will not only contribute to the understanding of musculoskeletal system and related repair mechanism, but also give insight into the advancement of regenerative medicine.
1. The function of mTORC1 in tendon development and injury repair
2. The function of ER stress in tendon development and injury repair
3. The function of Wnt1 in subchondral bone and development of osteoarthritis
Igor Bogush: Lab Manager
Narae Park: Postdoctoral Fellow
Yeonju Lee: Postdoctoral Fellow
Selected PublicationsLim J, Munivez E, Jiang MM, Song IW, Gannon F, Keene DR, Schweitzer R, Lee BH, Joeng KS.: mTORC1 Signaling is a Critical Regulator of Postnatal Tendon Development. Sci Rep. DEC 2017.
Joeng KS, Lee YC, Lim J, Chen Y, Jiang MM, Munivez E, Ambrose C, Lee BH: Osteocyte-specific WNT1 regulates osteoblast function during bone homeostasis. J Clin Invest 127(7): 2678-88, Jun 2017.
Hudson DM, Joeng KS, Werther R, Rajagopal A, Weis M, Lee BH, Eyre DR: Post-translationally abnormal collagens of prolyl 3-hydroxylase-2 null mice offer a pathobiological mechanism for the high myopia linked to human LEPREL1 mutations. J Biol Chem 290(13): 8613-22, Mar 2015.
Joeng KS, Lee YC, Jiang MM, Bertin TK, Chen Y, Abraham AM, Ding H, Bi X, Ambrose CG, Lee BH: The swaying mouse as a model of osteogenesis imperfecta caused by WNT1 mutations. Hum Mol Genet 23(15): 4035-42, Aug 2014.
Chen J, Tu X, Esen E, Joeng KS, Lin C, Arbeit JM, Rüegg MA, Hall MN, Ma L, Long F: WNT7B promotes bone formation in part through mTORC1. PLoS Genet 10(1): e1004145, Jan 2014.
Joeng KS, Long F: Wnt7b can replace Ihh to induce hypertrophic cartilage vascularization but not osteoblast differentiation during endochondral bone development. Bone Res 2: 14004, 2014.
Laine CM, Joeng KS, Campeau PM, Kiviranta R, Tarkkonen K, Grover M, Lu JT, Pekkinen M, Wessman M, Heino TJ, Nieminen-Pihala V, Aronen M, Laine T, Kröger H, Cole WG, Lehesjoki AE, Nevarez L, Krakow D, Curry CJ, Cohn DH, Gibbs RA, Lee BH, Mäkitie O: WNT1 mutations in early-onset osteoporosis and osteogenesis imperfecta. N Engl J Med 368(19): 1809-16, May 2013.
Joeng KS, Long F: Constitutive activation of Gli2 impairs bone formation in postnatal growing mice. PloS One 8(1): e55134, 2013.
Joeng KS, Schumacher CA, Zylstra-Diegel CR, Long F, Williams BO: Lrp5 and Lrp6 redundantly control skeletal development in the mouse embryo. Dev Biol 359(2): 222-9, Nov 2011.
Joeng KS, Long F: The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization. Development (Cambridge, England) 136(24): 4177-85, Dec 2009.