Kyu Sang Joeng

faculty photo
Assistant Professor of Orthopaedic Surgery
Department: Orthopaedic Surgery
Graduate Group Affiliations

Contact information
Mckay Orthopaedic Research Laboratory
331A Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104
Office: 2155733018
Fax: 2155732133
B.S. (Biology)
Yonsei University, 2001.
M.S. (Biology)
Yonsei University, 2003.
Ph.D. (Developmental Biology)
Washington University, 2010.
Permanent link
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Description of Research Expertise

Research Interest
The function of molecular and genetic signaling pathways involved in the development of musculoskeletal tissues.

Development, Regeneration, Genetics, Mouse, Signaling, Bone, Tendon, Cartilage

Research Details
My laboratory is interested in signaling pathways regulating development and homeostasis of musculoskeletal system. We use moues genetic models to study the function of ER stress, mTORC1, and Wnt signaling in bone, cartilage and tendon. I am also interested in the involvement of these signaling pathways in injury repair. Recent studies showed that developmental signaling pathways are involved in injury repair of musculoskeletal tissue. My laboratory combines several surgery models with mouse genetic models to investigate the function of signaling pathways in injury repair mechanism. Furthermore, my laboratory also studies the contribution of abnormal signaling pathways to the pathogenic mechanism of musculoskeletal diseases such as osteoarthritis, osteoporosis, and tendinopathy. I expect that my research programs will not only contribute to the understanding of musculoskeletal system and related repair mechanism, but also give insight into the advancement of regenerative medicine.

Rotation Projects
1. The function of mTORC1 in tendon development and injury repair
2. The function of ER stress in tendon development and injury repair
3. The function of Wnt1 in subchondral bone and development of osteoarthritis

Lab Personnel
Igor Bogush: Lab Manager
Narae Park: Postdoctoral Fellow
Yeonju Lee: Postdoctoral Fellow

Selected Publications

Lawson LY, Migotsky N, Chermside-Scabbo CJ, Shuster JT, Joeng KS, Civitelli R, Silva MJ: Loading-Induced Bone Formation is Mediated by Wnt1 Induction in Osteoblast-Lineage Cells. FASEB J August 2022.

3. Zhong L, Yao L, Holdreith N, Yu W, Gui T, Miao Z, Elkaim Y, Li M, Gong Y, Pacifici M, Maity A, Busch TM, Joeng KS, Cengel K, Seale P, Tong W, Qin L. : Transient expansion and myofibroblast conversion of adipogenic lineage precursors mediate bone marrow repair after radiation. Journal of Clinical Investigation April 2022.

2. Turin CG, Joeng KS, Kallish S, Raper A, Asher S, Campeau PM, Khan AN, Al Mukaddam M.: Heterozygous variant in WNT1 gene in two brothers with early onset osteoporosis. Bone Report December 2021.

Marom R, Burrage LC, Venditti R, Clément A, Blanco-Sánchez B, Jain M, Scott DA, Rosenfeld JA, Sutton VR, Shinawi M, Mirzaa G, DeVile C, Roberts R, Calder AD, Allgrove J, Grafe I, Lanza DG, Li X, Joeng KS, Eyre DR, Westerfield M, De Matteis MA, Lee B. : COPB2 loss of function causes a coatopathy with osteoporosis and developmental delay. Am J Hum Genet September 2021.

Park NR, Shetye S, Bougsh I, Keene DR, Tufa S, Hudson DM, Archer M, Qin L, Soslowsky LJ, Dyment NA, and Joeng KS. : Reticulocalbin 3 is Involved in Postnatal Tendon Development by Regulating Collagen Fibrillogenesis and cellular maturation. Scientific reports May 2021.

Shatha Alhamdi, Yi‐Chien Lee, Shimul Chowdhury, Peter H. Byers, Michael Gottschalk, Ryan J. Taft, Kyu Sang Joeng, Brendan H. Lee, Lynne M. Bird : Heterozygous WNT1 variant causing a variable bone phenotype. American Journal of Medical Genetics November 2018.

Lim J, Munivez E, Jiang MM, Song IW, Gannon F, Keene DR, Schweitzer R, Lee BH, Joeng KS.: mTORC1 Signaling is a Critical Regulator of Postnatal Tendon Development. Sci Rep. DEC 2017.

Joeng KS, Lee YC, Lim J, Chen Y, Jiang MM, Munivez E, Ambrose C, Lee BH: Osteocyte-specific WNT1 regulates osteoblast function during bone homeostasis. J Clin Invest 127(7): 2678-88, Jun 2017.

Hudson DM, Weis M, Rai J, Joeng KS, Dimori M, Lee BH, Morello R, Eyre DR: P3h3-null and Sc65-null Mice Phenocopy the Collagen Lysine Under-hydroxylation and Cross-linking Abnormality of Ehlers-Danlos Syndrome Type VIA. J Biol Chem 292(9): 3877-87, Mar 2017.

Rajagopal A, Homan EP, Joeng KS, Suzuki M, Bertin T, Cela R, Munivez E, Dawson B, Jiang MM, Gannon F, Crawford S, Lee BH: Restoration of the serum level of SERPINF1 does not correct the bone phenotype in Serpinf1 null mice. Mol Genet Metab 117(3): 378-82, Mar 2016.

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Last updated: 01/15/2024
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