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Joseph Cichon, MD, PhD
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Assistant Professor of Anesthesiology and Critical Care
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Director of In vivo imaging center for anesthetics and psychedelics, Penn
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Department: Anesthesiology and Critical Care
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Graduate Group Affiliations
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- Neuroscience e
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Contact information
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Hospital of the University of Pennsylvania
36 Department of Anesthesiology and Critical Care
47 3400 Spruce Street, Suite 680 Dulles
Philadelphia, PA 19104
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36 Department of Anesthesiology and Critical Care
47 3400 Spruce Street, Suite 680 Dulles
Philadelphia, PA 19104
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Education:
21 7 BS c
36 Pennsylvania State University, 2008.
21 7 MS c
36 Pennsylvania State University, 2009.
21 8 PhD 26 (Neuroscience & Physiology) c
2f NYU School of Medicine, 2015.
21 7 MD c
2f NYU School of Medicine, 2017.
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Permanent link21 7 BS c
36 Pennsylvania State University, 2008.
21 7 MS c
36 Pennsylvania State University, 2009.
21 8 PhD 26 (Neuroscience & Physiology) c
2f NYU School of Medicine, 2015.
21 7 MD c
2f NYU School of Medicine, 2017.
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Description of Clinical Expertise
64 Neuroanesthesia, general anesthesia, sedation, pharmacology, critical care medicine.71
Description of Research Expertise
73 The cellular and circuit mechanisms of anesthetics, rapid-acting antidepressants, and psychedelics.e 29
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cd Bera K, Looger LL, Proekt A, Cichon J.: Cortical Mechanisms Contributing to Ketamine-Induced Dissociation. Neuroscientist Dec 2025.
11e Hammo A, Wisser S, Cichon J.: Single-dose psilocybin rapidly and sustainably relieves allodynia and anxiodepressive-like behaviors in mouse models of chronic pain. Nature Neuroscience 28(11): 2285-2295, Nov 2025.
114 Wisser S, Blackwood EB, Bera K, Wasilczuk AZ, Looger LL, Proekt A, Cichon J.: Rapid neonatal AAV delivery for adult cortical two-photon imaging of genetically encoded sensors. iScience 28(11), Oct 2025.
170 Joseph Cichon, Thomas T. Joseph, Xinguo Lu, Andrzej Z. Wasilczuk, Max B. Kelz, Steven J. Mennerick, Charles F. Zorumski & Peter Nagele : Nitrous Oxide activates layer 5 prefrontal neurons via SK2 channel inhibition for antidepressant effect. Nature Communication. Nature (16), 2999, April 2025.
dd The Last Show with David Cooper: Laughing gas appears to reduce depression, but researchers don't totally understand why. Corus Radio network 2025.
170 Daniel Markman, Andrzej Z. Wasilczuk, and Joseph Michael Cichon: General Anesthesia Occludes Ketamine's Antidepressant Response in a Rodent Model of Chronic Stress. Psychedelic Medicine Mary Ann Liebert, May 2024 Notes: Published online ahead of print. https://doi.org/10.1089/psymed.2024.000.
168 Joseph Cichon, Andrzej Z. Wasilczuk, Loren L. Looger, Diego Contreras, Max B. Kelz & Alex Proekt: Ketamine triggers a switch in excitatory neuronal activity across neocortex. Nature Neuroscience Nature Neuroscience 26: 39-52, Nov 2022 Notes: https://doi.org/10.1038/s41593-022-01203-5.
103 Joseph Cichon, Renyu Liu, and Hoang V. Le: Therapeutic Potential of Salvinorin A and Its Analogues in Various Neurological Disorders. Transl Perioper Pain Med 9(2): 452–457, June 2022.
f6 Sun L, Zhou H, Cichon J, Yang G.: Experience and sleep-dependent synaptic plasticity: from structure to activity. Philos Trans R Soc Lond B Biol Sci 375: 20190234, May 2020.
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Selected Publications
104 Zorumski CF, Cichon J, Izumi Y, Zeffiro T, Mennerick S, Nagele P, Conway CR.: Rapid antidepressant potential of nitrous oxide: current state and major questions. Mol Psychiatry Dec 2025.cd Bera K, Looger LL, Proekt A, Cichon J.: Cortical Mechanisms Contributing to Ketamine-Induced Dissociation. Neuroscientist Dec 2025.
11e Hammo A, Wisser S, Cichon J.: Single-dose psilocybin rapidly and sustainably relieves allodynia and anxiodepressive-like behaviors in mouse models of chronic pain. Nature Neuroscience 28(11): 2285-2295, Nov 2025.
114 Wisser S, Blackwood EB, Bera K, Wasilczuk AZ, Looger LL, Proekt A, Cichon J.: Rapid neonatal AAV delivery for adult cortical two-photon imaging of genetically encoded sensors. iScience 28(11), Oct 2025.
170 Joseph Cichon, Thomas T. Joseph, Xinguo Lu, Andrzej Z. Wasilczuk, Max B. Kelz, Steven J. Mennerick, Charles F. Zorumski & Peter Nagele : Nitrous Oxide activates layer 5 prefrontal neurons via SK2 channel inhibition for antidepressant effect. Nature Communication. Nature (16), 2999, April 2025.
dd The Last Show with David Cooper: Laughing gas appears to reduce depression, but researchers don't totally understand why. Corus Radio network 2025.
170 Daniel Markman, Andrzej Z. Wasilczuk, and Joseph Michael Cichon: General Anesthesia Occludes Ketamine's Antidepressant Response in a Rodent Model of Chronic Stress. Psychedelic Medicine Mary Ann Liebert, May 2024 Notes: Published online ahead of print. https://doi.org/10.1089/psymed.2024.000.
168 Joseph Cichon, Andrzej Z. Wasilczuk, Loren L. Looger, Diego Contreras, Max B. Kelz & Alex Proekt: Ketamine triggers a switch in excitatory neuronal activity across neocortex. Nature Neuroscience Nature Neuroscience 26: 39-52, Nov 2022 Notes: https://doi.org/10.1038/s41593-022-01203-5.
103 Joseph Cichon, Renyu Liu, and Hoang V. Le: Therapeutic Potential of Salvinorin A and Its Analogues in Various Neurological Disorders. Transl Perioper Pain Med 9(2): 452–457, June 2022.
f6 Sun L, Zhou H, Cichon J, Yang G.: Experience and sleep-dependent synaptic plasticity: from structure to activity. Philos Trans R Soc Lond B Biol Sci 375: 20190234, May 2020.
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Contact Us
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