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Huasheng Yu, Ph.D.
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Research Assistant Professor of Neuroscience
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Department: Neuroscience
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Contact information
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3610 Hamilton Walk
37 145 Johnson Pavilion
Philadelphia, PA 19104
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37 145 Johnson Pavilion
Philadelphia, PA 19104
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Office: 2158215984
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Education:
21 9 B.S. 29 (Life Sciences & Technologies) c
2b Lanzhou University, 2013.
21 a Ph.D. 19 (Neurobiology) c
2a Peking University, 2019.
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Permanent link21 9 B.S. 29 (Life Sciences & Technologies) c
2b Lanzhou University, 2013.
21 a Ph.D. 19 (Neurobiology) c
2a Peking University, 2019.
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b8 Sensory Neuron Transcriptomics: Development and application of laser capture microdissection (LCM)-based single-soma RNA sequencing to profile human peripheral sensory neurons.
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99 Molecular Mechanisms of Itch and Pain: Identified MRGPRX4 as a bile acid receptor linked to cholestatic itch, uncovering new therapeutic targets.
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9a Neural Circuit Manipulation & Functional Studies: Utilization of mouse genetics and behavioral assays to investigate somatosensory neuron function.
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Description of Research Expertise
cc I specialize in somatosensory neuroscience, with a focus on the molecular and cellular mechanisms underlying chronic pain and itch in both humans and animal models. My expertise includes:8
b8 Sensory Neuron Transcriptomics: Development and application of laser capture microdissection (LCM)-based single-soma RNA sequencing to profile human peripheral sensory neurons.
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99 Molecular Mechanisms of Itch and Pain: Identified MRGPRX4 as a bile acid receptor linked to cholestatic itch, uncovering new therapeutic targets.
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9a Neural Circuit Manipulation & Functional Studies: Utilization of mouse genetics and behavioral assays to investigate somatosensory neuron function.
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12d Gautam M, Yamada A, Yamada AI, Wu Q, Kridsada K, Ling J, Yu H, Dong P, Ma M, Gu J, Luo W.: Distinct local and global functions of mouse Aβ low-threshold mechanoreceptors in mechanical nociception. Nat Commun 15: 2911, Apr 2024.
1a7 Yu H, Nagi SS, Usoskin D, Hu Y, Kupari J, Bouchatta O, Yan H, Cranfill SL, Gautam M, Su Y, Lu Y, Wymer J, Glanz M, Albrecht P, Song H, Ming GL, Prouty S, Seykora J, Wu H, Ma M, Marshall A, Rice FL, Li M, Olausson H, Ernfors P, Luo W.: Leveraging deep single-soma RNA sequencing to explore the neural basis of human somatosensation. Nat Neurosci 2024.
1d5 Bouchatta O, Brodzki M, Manouze H, Carballo GB, Kindström E, de-Faria FM, Yu H, Kao AR, Thorell O, Liljencrantz J, Ng KKW, Frangos E, Ragnemalm B, Saade D, Bharucha-Goebel D, Szczot I, Moore W, Terejko K, Cole J, Bonnemann C, Luo W, Mahns DA, Larsson M, Gerling GJ, Marshall AG, Chesler AT, Olausson H, Nagi SS, Szczot M.: PIEZO2-dependent rapid pain system in humans and mice. bioRxiv Dec 2023.
1ab Yu H, Xiong J, Ye AY, Cranfill SL, Cannonier T, Gautam M, Zhang M, Bilal R, Park JE, Xue Y, Polam V, Vujovic Z, Dai D, Ong W, Ip J, Hsieh A, Mimouni N, Lozada A, Sosale M, Ahn A, Ma M, Ding L, Arsuaga J, Luo W.: Scratch-AID, a deep learning-based system for automatic detection of mouse scratching behavior with high accuracy. Elife 11: e84042, Dec 2022.
c0 Yu H, Cranfill SL, Luo W.: ErbB4(+) spinal cord dorsal horn neurons process heat pain. Neuron 110: 2206-2208, Jul 2022.
101 Qian C, Wu Z, Sun R, Yu H, Zeng J, Rao Y, Li Y.: Localization, proteomics, and metabolite profiling reveal a putative vesicular transporter for UDP-glucose. Elife 10: e65417, Jul 2021.
aa Yu H, Wangensteen K, Deng T, Li Y, Luo W.: MRGPRX4 in Cholestatic Pruritus. Semin Liver Dis 2021.
12b Yu H, Zhao T, Liu S, Wu Q, Johnson O, Wu Z, Zhuang Z, Shi Y, Peng L, He R, Yang Y, Sun J, Wang X, Xu H, Zeng Z, Zou P, Lei X, Luo W, Li Y.: MRGPRX4 is a bile acid receptor for human cholestatic itch. Elife 8: e48431, Sep 2019.
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Selected Publications
14d Yang J, Zhao T, Fan J, Zou H, Lan G, Guo F, Shi Y, Ke H, Yu H, Yue Z, Wang X, Bai Y, Li S, Liu Y, Wang X, Chen Y, Li Y, Lei X.: Structure-guided discovery of bile acid derivatives for treating liver diseases without causing itch. Cell 187: 7164-7182, Dec 2024.12d Gautam M, Yamada A, Yamada AI, Wu Q, Kridsada K, Ling J, Yu H, Dong P, Ma M, Gu J, Luo W.: Distinct local and global functions of mouse Aβ low-threshold mechanoreceptors in mechanical nociception. Nat Commun 15: 2911, Apr 2024.
1a7 Yu H, Nagi SS, Usoskin D, Hu Y, Kupari J, Bouchatta O, Yan H, Cranfill SL, Gautam M, Su Y, Lu Y, Wymer J, Glanz M, Albrecht P, Song H, Ming GL, Prouty S, Seykora J, Wu H, Ma M, Marshall A, Rice FL, Li M, Olausson H, Ernfors P, Luo W.: Leveraging deep single-soma RNA sequencing to explore the neural basis of human somatosensation. Nat Neurosci 2024.
1d5 Bouchatta O, Brodzki M, Manouze H, Carballo GB, Kindström E, de-Faria FM, Yu H, Kao AR, Thorell O, Liljencrantz J, Ng KKW, Frangos E, Ragnemalm B, Saade D, Bharucha-Goebel D, Szczot I, Moore W, Terejko K, Cole J, Bonnemann C, Luo W, Mahns DA, Larsson M, Gerling GJ, Marshall AG, Chesler AT, Olausson H, Nagi SS, Szczot M.: PIEZO2-dependent rapid pain system in humans and mice. bioRxiv Dec 2023.
1ab Yu H, Xiong J, Ye AY, Cranfill SL, Cannonier T, Gautam M, Zhang M, Bilal R, Park JE, Xue Y, Polam V, Vujovic Z, Dai D, Ong W, Ip J, Hsieh A, Mimouni N, Lozada A, Sosale M, Ahn A, Ma M, Ding L, Arsuaga J, Luo W.: Scratch-AID, a deep learning-based system for automatic detection of mouse scratching behavior with high accuracy. Elife 11: e84042, Dec 2022.
c0 Yu H, Cranfill SL, Luo W.: ErbB4(+) spinal cord dorsal horn neurons process heat pain. Neuron 110: 2206-2208, Jul 2022.
101 Qian C, Wu Z, Sun R, Yu H, Zeng J, Rao Y, Li Y.: Localization, proteomics, and metabolite profiling reveal a putative vesicular transporter for UDP-glucose. Elife 10: e65417, Jul 2021.
aa Yu H, Wangensteen K, Deng T, Li Y, Luo W.: MRGPRX4 in Cholestatic Pruritus. Semin Liver Dis 2021.
12b Yu H, Zhao T, Liu S, Wu Q, Johnson O, Wu Z, Zhuang Z, Shi Y, Peng L, He R, Yang Y, Sun J, Wang X, Xu H, Zeng Z, Zou P, Lei X, Luo W, Li Y.: MRGPRX4 is a bile acid receptor for human cholestatic itch. Elife 8: e48431, Sep 2019.
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Contact Us
34Department of Neuroscience
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Perelman School of Medicine at the University of Pennsylvania
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