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Li-Feng Jiang-Xie, PhD
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Assistant Professor of Neuroscience
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Department: Neuroscience
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Graduate Group Affiliations
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- Pharmacology 64
- Neuroscience e
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Contact information
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CRB Room 217A
16 415 Curie Blvd
1e Philadelphia, PA 19104
30 United States
Philadelphia, PA 19104
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16 415 Curie Blvd
1e Philadelphia, PA 19104
30 United States
Philadelphia, PA 19104
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Education:
21 7 BS 17 (Psychology) c
33 National Taiwan University, 2012.
21 7 MS 24 (Brain and Mind Sciences) c
33 National Taiwan University, 2013.
21 8 PhD 19 (Neurobiology) c
28 Duke University, 2019.
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Permanent link21 7 BS 17 (Psychology) c
33 National Taiwan University, 2012.
21 7 MS 24 (Brain and Mind Sciences) c
33 National Taiwan University, 2013.
21 8 PhD 19 (Neurobiology) c
28 Duke University, 2019.
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335 We believe that the primary function of sleep is to restore metabolic homeostasis. Excess waste produced by neuronal activity during wakefulness generates the drive to sleep, while the function of sleep is to remove these harmful wastes, ensuring optimal brain performance. Our recent research has discovered that neurons, acting as small biophysical pumps, synchronize their activity during sleep to create large-amplitude and rhythmic ionic waves (currents) in the brain's interstitial fluid. These waves power fluid flow, effectively clearing metabolic waste from the brain. We summarize this principle as, neurons that fire together shower together. In light of this foundational concept, we aim to investigate how neural circuits are shaped by the demand for self-cleansing throughout the evolution of sleep.
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45 Here are a few research directions we are currently pursuing:
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7a (1) Recording and visualizing neural activity and brain interstitial fluid dynamics across different brain states.
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6b (2) Identifying the macroscale circuitry organizing global fluid perfusion and molecular clearance.
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64 (3) Pinpointing the micro-circuitry orchestrating local fluid perfusion and brain clearance.
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6e (4) Determining how neural dynamics regulate the metabolism of endogenous disease-associated proteins.
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Description of Research Expertise
1f1 The primary objective of our lab is to unveil the mystery of sleep. By integrating diverse experimental and computational tools—including electrophysiology, two-photon imaging, proteomics, numerical modeling, and artificial intelligence—we aim to develop a coherent theory to explain the function and origin of sleep. Currently, we are focused on advancing the self-cleansing brain hypothesis for sleep, which also provides profound insights into neurodegenerative disorders.8
335 We believe that the primary function of sleep is to restore metabolic homeostasis. Excess waste produced by neuronal activity during wakefulness generates the drive to sleep, while the function of sleep is to remove these harmful wastes, ensuring optimal brain performance. Our recent research has discovered that neurons, acting as small biophysical pumps, synchronize their activity during sleep to create large-amplitude and rhythmic ionic waves (currents) in the brain's interstitial fluid. These waves power fluid flow, effectively clearing metabolic waste from the brain. We summarize this principle as, neurons that fire together shower together. In light of this foundational concept, we aim to investigate how neural circuits are shaped by the demand for self-cleansing throughout the evolution of sleep.
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45 Here are a few research directions we are currently pursuing:
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7a (1) Recording and visualizing neural activity and brain interstitial fluid dynamics across different brain states.
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6b (2) Identifying the macroscale circuitry organizing global fluid perfusion and molecular clearance.
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64 (3) Pinpointing the micro-circuitry orchestrating local fluid perfusion and brain clearance.
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6e (4) Determining how neural dynamics regulate the metabolism of endogenous disease-associated proteins.
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e9 Jiang-Xie LF, Drieu A, Bhasiin K, Quintero D, Smirnov I, Kipnis J.: Neuronal dynamics direct cerebrospinal fluid perfusion and brain clearance. Nature Feb 2024.
fb Jiang-Xie LF, Yin L, Zhao S, Prevosto V, Han BX, Dzirasa K, Wang F.: A Common Neuroendocrine Substrate for Diverse General Anesthetics and Sleep. Neuron 102: 1053-1065, Jun 2019.
136 Jiang-Xie LF, Liao HM, Chen CH, Chen YT, Ho SY, Lu DH, Lee LJ, Liou HH, Fu WM, Gau SS.: Autism-associated gene Dlgap2 mutant mice demonstrate exacerbated aggressive behaviors and orbitofrontal cortex deficits. Mol Autism 5: 32, May 2014.
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Selected Publications
a6 Jiang-Xie LF, Drieu A, Kipnis J.: Waste clearance shapes aging brain health. Neuron Oct 2024.e9 Jiang-Xie LF, Drieu A, Bhasiin K, Quintero D, Smirnov I, Kipnis J.: Neuronal dynamics direct cerebrospinal fluid perfusion and brain clearance. Nature Feb 2024.
fb Jiang-Xie LF, Yin L, Zhao S, Prevosto V, Han BX, Dzirasa K, Wang F.: A Common Neuroendocrine Substrate for Diverse General Anesthetics and Sleep. Neuron 102: 1053-1065, Jun 2019.
136 Jiang-Xie LF, Liao HM, Chen CH, Chen YT, Ho SY, Lu DH, Lee LJ, Liou HH, Fu WM, Gau SS.: Autism-associated gene Dlgap2 mutant mice demonstrate exacerbated aggressive behaviors and orbitofrontal cortex deficits. Mol Autism 5: 32, May 2014.
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Contact Us
34Department of Neuroscience
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Perelman School of Medicine at the University of Pennsylvania
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415 Curie Blvd
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Philadelphia, PA 19104
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Fax: (215) 573-0833
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(215) 898-8754
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Email Us
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