Faculty

Derek Alan Oldridge, M.D., Ph.D.

Assistant Professor of Pathology and Laboratory Medicine

Department: Pathology and Laboratory Medicine

Graduate Group Affiliations

Contact information

Children's Hospital of Philadelphia
Colket Translational Research Building Rm. 9028
3501 Civic Center Boulevard
Philadelphia, PA 19104

Email:
oldridged@chop.edu

Education:
B.A.
Reed College (Interdisciplinary Chemistry/Physics), 2007.
Ph.D.
University of Pennsylvania (Genomics and Computational Biology), 2015.
M.A.
The Wharton School at the University of Pennsylvania (Statistics), 2015.
M.D.
Perelman School of Medicine at the University of Pennsylvania, 2017.

Links
The Oldridge Lab Website

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Clinical Expertise

Histocompatibility
Immunogenetics
Molecular Pathology
Clinical Pathology

Description of Research Expertise

Bioinformatics
Cancer
Genomics
Immunology
Immunotherapy
Pediatric Oncology
Statistics

Selected Publications

Lee J, Takemaru L, Bappy DM, Jeong YS, Jeong WK, Oldridge D, Kim D, Ahn S, Lee SH: Adaptive compression framework for giga-pixel whole slide images. Nat Commun Dec 2025 Notes: doi: 10.1038/s41467-025-66889-0.

Dubensky SB, Zhu Y, Gallagher M, Kumashie KG, Lu T, Tedesco J, De Luna N, Premo K, Qi Y, Rachimi S, Cabrera EC, Fulmer B, Meremikwu IC, Carter A, Henrickson SE, Romberg N, Baxter AE, *Oldridge DA, *Vella LA: Multimodal analysis defines GNG4 as a distinguishing feature of germinal center-positioned CD4 T follicular helper cells in humans. bioRxiv Dec 2025 Notes: doi: 10.64898/2025.12.10.693235.

Lee J, Leiby JS, Takemaru L, Huang Y, Noh MG, Kim J, Lee B, Lee ME, Oldridge DA, Eun YG, Lee HJ, Lee YC, Kim D: Clinically aligned multi-modal image-text model for pan-cancer prognosis prediction. BioData Min Dec 2025 Notes: doi: 10.1186/s13040-025-00495-0.

Piyadasa H, Oberlton B, Ribi M, Leow K, Ranek JS, Averbukh I, Amouzgar M, Liu CC, Franchina DG, Greenwald NF, McCaffrey EF, Kumar R, Ferrian S, Tsai AG, Filiz F, Fullaway CC, Bosse M, Varra SR, Kong A, Sowers C, Gephart MH, Nuñez-Perez P, Yang E, Travers M, Schachter MJ, Liang S, Santi MR, Bucktrout S, Gherardini PF, Connolly J, Cole K, Barish ME, Brown CE, Oldridge DA, Drake RR, Phillips JJ, Okada H, Prins R, Bendall SC, Angelo M: Multi-omic landscape of human gliomas from diagnosis to treatment and recurrence Cancer Cell Dec 2025 Notes: doi: 10.1016/j.ccell.2025.11.006.

Mumau MD, Gonzalez MV, Forsyth KS, Pampena MB, Irvine AH, Lavery CLM, Zinski JM, Miller ID, Dubensky SB, Oldridge DA, Vella LA, Betts MR, Fajgenbaum DC: Dysregulated lymphocyte localization in idiopathic multicentric Castleman disease. bioRxiv Dec 2025 Notes: DOI: 10.64898/2025.12.12.693846

Weichert-Leahey N, Berezovskaya A, Zimmerman MW, Alvarez-Calderon F, Winschel M, Salhotra S, Mabe N, Perez-Atayde A, Vitorino FNL, Garcia B, Gerdemann U, Stegmaier K, Durbin AD, Oldridge DA, Abraham BJ, Look AT.: KAT6A/B inhibition synergizes with retinoic acid and enhances the efficacy of GD2-targeted immunotherapy in neuroblastoma. bioRxiv Jul 2025 Notes: 10.1101/2025.07.01.662644.

Shankar N, Kreiger PA, Oldridge DA, Picarsic J, Arnold MA: Digital Pathology and Artificial Intelligence in Pediatric Pathology Surgical Pathology Clinics Jun 2025 Notes: doi: 10.1016/j.path.2024.11.006.

Zhang Y, Abousamra S, Hasan M, Torre-Healy L, Krichevsky S, Shrestha S, Bremer E, Oldridge DA, Rech AJ, Furth EE, Bocklage TJ, Levens JS, Hands I, Durbin EB, Samaras D, Kurc T, Saltz JH, Gupta R: Pathomics Image Analysis of Tumor Infiltrating Lymphocytes (TILs) in Colon Cancer. Res Sq Apr 2025 Notes: doi: 10.21203/rs.3.rs-6173056/v1.

Piyadasa H, Oberlton B, Ribi M, Ranek JS, Averbukh I, Leow K, Amouzgar M, Liu CC, Greenwald NF, McCaffrey EF, Kumar R, Ferrian S, Tsai AG, Filiz F, Fullaway CC, Bosse M, Varra SR, Kong A, Sowers C, Gephart MH, Nuñez-Perez P, Yang E, Travers M, Schachter MJ, Liang S, Santi MR, Bucktrout S, Gherardini PF, Connolly J, Cole K, Barish ME, Brown CE, Oldridge DA, Drake RR, Phillips JJ, Okada H, Prins R, Bendall SC, Angelo M: Multi-omic landscape of human gliomas from diagnosis to treatment and recurrence. bioRxiv Apr 2025 Notes: doi: 10.1101/2025.03.12.642624.

Barnett Dubensky S, Gallagher M, Kumashie KG, Lu T, Zhu Y, Tedesco J, De Luna N, Premo K, Qi Y, Rachimi S, Cruz Cabrera E, Fulmer F, Meremikwu IC, Carter A, Henrickson SE, Romberg N, Baxter AE, Oldridge DA*, Vella LA*: Multimodal analysis resolves GNG4 as a distinguishing feature of activated germinal center-resident Tfh in humans. Mid-Atlantic Bioinformatics Conference (MABC) 2025 Annual Meeting 2025.