Faculty

Derek Alan Oldridge, M.D., Ph.D.

Assistant Professor of Pathology and Laboratory Medicine

Department: Pathology and Laboratory Medicine

Graduate Group Affiliations

Contact information

Children's Hospital of Philadelphia
Colket Translational Research Building Rm. 9028
3501 Civic Center Boulevard
Philadelphia, PA 19104

Email:
oldridged@chop.edu

Education:
B.A.
Reed College (Interdisciplinary Chemistry/Physics), 2007.
M.A.
The Wharton School at the University of Pennsylvania (Statistics), 2015.
Ph.D.
University of Pennsylvania (Genomics and Computational Biology), 2015.
M.D.
Perelman School of Medicine at the University of Pennsylvania, 2017.

Links
The Oldridge Lab Website

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Clinical Expertise

Histocompatibility
Immunogenetics
Molecular Pathology
Clinical Pathology

Description of Research Expertise

Bioinformatics
Cancer
Genomics
Immunology
Immunotherapy
Pediatric Oncology
Statistics

Selected Publications

Weichert-Leahey N, Berezovskaya A, Zimmerman MW, Alvarez-Calderon F, Winschel M, Salhotra S, Mabe N, Perez-Atayde A, Vitorino FNL, Garcia B, Gerdemann U, Stegmaier K, Durbin AD, Oldridge DA, Abraham BJ, Look AT.: KAT6A/B inhibition synergizes with retinoic acid and enhances the efficacy of GD2-targeted immunotherapy in neuroblastoma. bioRxiv Jul 2025 Notes: 10.1101/2025.07.01.662644.

Shankar N, Kreiger PA, Oldridge DA, Picarsic J, Arnold MA: Digital Pathology and Artificial Intelligence in Pediatric Pathology Surgical Pathology Clinics Jun 2025 Notes: doi: 10.1016/j.path.2024.11.006.

Zhang Y, Abousamra S, Hasan M, Torre-Healy L, Krichevsky S, Shrestha S, Bremer E, Oldridge DA, Rech AJ, Furth EE, Bocklage TJ, Levens JS, Hands I, Durbin EB, Samaras D, Kurc T, Saltz JH, Gupta R: Pathomics Image Analysis of Tumor Infiltrating Lymphocytes (TILs) in Colon Cancer. Res Sq Apr 2025 Notes: doi: 10.21203/rs.3.rs-6173056/v1.

Piyadasa H, Oberlton B, Ribi M, Ranek JS, Averbukh I, Leow K, Amouzgar M, Liu CC, Greenwald NF, McCaffrey EF, Kumar R, Ferrian S, Tsai AG, Filiz F, Fullaway CC, Bosse M, Varra SR, Kong A, Sowers C, Gephart MH, Nuñez-Perez P, Yang E, Travers M, Schachter MJ, Liang S, Santi MR, Bucktrout S, Gherardini PF, Connolly J, Cole K, Barish ME, Brown CE, Oldridge DA, Drake RR, Phillips JJ, Okada H, Prins R, Bendall SC, Angelo M: Multi-omic landscape of human gliomas from diagnosis to treatment and recurrence. bioRxiv Apr 2025 Notes: doi: 10.1101/2025.03.12.642624.

Barnett Dubensky S, Gallagher M, Kumashie KG, Lu T, Zhu Y, Tedesco J, De Luna N, Premo K, Qi Y, Rachimi S, Cruz Cabrera E, Fulmer F, Meremikwu IC, Carter A, Henrickson SE, Romberg N, Baxter AE, Oldridge DA*, Vella LA*: Multimodal analysis resolves GNG4 as a distinguishing feature of activated germinal center-resident Tfh in humans. Mid-Atlantic Bioinformatics Conference (MABC) 2025 Annual Meeting 2025.

Barnett Dubensky S, Gallagher M, Kumashie KG, Lu T, Zhu Y, Tedesco J, De Luna N, Premo K, Qi Y, Rachimi S, Cruz Cabrera E, Fulmer F, Meremikwu IC, Carter A, Henrickson SE, Romberg N, Baxter AE, Oldridge DA*, Vella LA*: Multimodal analysis resolves GNG4 as a distinguishing feature of activated germinal center-resident T follicular helper cells in humans. American Association of Immunologists (AAI) 2026 Annual Meeting 2025.

Zhu, Irina Y., Dubensky, Sam B., Carter, Ashley, Cabrera, Emylette C., Baxter, Amy E., Romberg, Neil D., Oldridge, Derek A.: AI-driven 3D Digital Pathology of Immune Follicular Structures in Human. Mid-Atlantic Bioinformatics Conference (MABC) 2025 Annual Meeting 2025.

Yu WW, Barrett JNP, Tong J, Lin MJ, Marohn M, Devlin JC, Herrera A, Remark J, Levine J, Liu PK, Fang V, Zellmer AM, Oldridge DA, Wherry EJ, Lin JR, Chen JY, Sorger P, Santagata S, Krueger JG, Ruggles KV, Wang F, Su C, Koralov SB, Wang J, Chiu ES, Lu CP.: Skin immune-mesenchymal interplay within tertiarylymphoid structures promotes autoimmunepathogenesis in hidradenitis suppurativa. Immunity 57: 2827-2842, Dec 2024.

Wang K, Coutifaris P, Brocks D, Wang G, Azar T, Solis S, Nandi A, Anderson S, Han N, Manne S, Kiner E, Sachar C, Lucas M, George S, Yan PK, Kier MW, Laughlin AI, Kothari S, Giles J, Mathew D, Ghinnagow R, Alanio C, Flowers A, Xu W, Tenney DJ, Xu X, Amaravadi RK, Karakousis GC, Schuchter LM, Buggert M, Oldridge D, Minn AJ, Blank C, Weber JS, Mitchell TC, Farwell MD, Herati RS, Huang AC.: Combination anti-PD-1 and anti-CTLA-4 therapy generates waves of clonal responses that include progenitor-exhausted CD8(+) T cells. Cancer Cell 42: 1582-1597, Sep 2024.

Bandyopadhyay S, Duffy MP, Ahn KJ, Sussman JH, Pang M, Smith D, Duncan G, Zhang I, Huang J, Lin Y, Xiong B, Imtiaz T, Chen CH, Thadi A, Chen C, Xu J, Reichart M, Martinez Z, Diorio C, Chen C, Pillai V, Snaith O, Oldridge D, Bhattacharyya S, Maillard I, Carroll M, Nelson C, Qin L, Tan K.: Mapping the cellular biogeography of human bone marrow niches using single-cell transcriptomics and proteomic imaging. Cell 187(12): 3120-3140, Jun 2024 Notes: doi: 10.1016/j.cell.2024.04.013.