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Derek Alan Oldridge, M.D., Ph.D.
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Assistant Professor of Pathology and Laboratory Medicine
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Department: Pathology and Laboratory Medicine
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Graduate Group Affiliations
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Contact information
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Children's Hospital of Philadelphia
38 Colket Translational Research Building Rm. 9028
3e 3501 Civic Center Boulevard
Philadelphia, PA 19104
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38 Colket Translational Research Building Rm. 9028
3e 3501 Civic Center Boulevard
Philadelphia, PA 19104
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Email:
oldridged@chop.edu
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oldridged@chop.edu
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Education:
21 a B.A. c
4b Reed College (Interdisciplinary Chemistry/Physics), 2007.
21 a Ph.D. c
58 University of Pennsylvania (Genomics and Computational Biology), 2015.
21 9 M.A. c
5a The Wharton School at the University of Pennsylvania (Statistics), 2015.
21 9 M.D. c
56 Perelman School of Medicine at the University of Pennsylvania, 2017.
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Permanent link21 a B.A. c
4b Reed College (Interdisciplinary Chemistry/Physics), 2007.
21 a Ph.D. c
58 University of Pennsylvania (Genomics and Computational Biology), 2015.
21 9 M.A. c
5a The Wharton School at the University of Pennsylvania (Statistics), 2015.
21 9 M.D. c
56 Perelman School of Medicine at the University of Pennsylvania, 2017.
c
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16 Immunogenetics
1b Molecular Pathology
19 Clinical Pathology
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e Cancer
10 Genomics
12 Immunology
15 Immunotherapy
1a Pediatric Oncology
11 Statistics
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Description of Clinical Expertise
23 Histocompatibility16 Immunogenetics
1b Molecular Pathology
19 Clinical Pathology
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Description of Research Expertise
1f Bioinformaticse Cancer
10 Genomics
12 Immunology
15 Immunotherapy
1a Pediatric Oncology
11 Statistics
e 29
23
1d5 Dubensky SB, Zhu Y, Gallagher M, Kumashie KG, Lu T, Tedesco J, De Luna N, Premo K, Qi Y, Rachimi S, Cabrera EC, Fulmer B, Meremikwu IC, Carter A, Henrickson SE, Romberg N, Baxter AE, *Oldridge DA, *Vella LA: Multimodal analysis defines GNG4 as a distinguishing feature of germinal center-positioned CD4 T follicular helper cells in humans. bioRxiv Dec 2025 Notes: doi: 10.64898/2025.12.10.693235.
14a Lee J, Leiby JS, Takemaru L, Huang Y, Noh MG, Kim J, Lee B, Lee ME, Oldridge DA, Eun YG, Lee HJ, Lee YC, Kim D: Clinically aligned multi-modal image-text model for pan-cancer prognosis prediction. BioData Min Dec 2025 Notes: doi: 10.1186/s13040-025-00495-0.
238 Piyadasa H, Oberlton B, Ribi M, Leow K, Ranek JS, Averbukh I, Amouzgar M, Liu CC, Franchina DG, Greenwald NF, McCaffrey EF, Kumar R, Ferrian S, Tsai AG, Filiz F, Fullaway CC, Bosse M, Varra SR, Kong A, Sowers C, Gephart MH, Nuñez-Perez P, Yang E, Travers M, Schachter MJ, Liang S, Santi MR, Bucktrout S, Gherardini PF, Connolly J, Cole K, Barish ME, Brown CE, Oldridge DA, Drake RR, Phillips JJ, Okada H, Prins R, Bendall SC, Angelo M: Multi-omic landscape of human gliomas from diagnosis to treatment and recurrence 56 Cancer Cell Dec 2025 Notes: doi: 10.1016/j.ccell.2025.11.006.
15a Mumau MD, Gonzalez MV, Forsyth KS, Pampena MB, Irvine AH, Lavery CLM, Zinski JM, Miller ID, Dubensky SB, Oldridge DA, Vella LA, Betts MR, Fajgenbaum DC: Dysregulated lymphocyte localization in idiopathic multicentric Castleman disease. bioRxiv Dec 2025 Notes: DOI: 10.64898/2025.12.12.693846 14
1cb Weichert-Leahey N, Berezovskaya A, Zimmerman MW, Alvarez-Calderon F, Winschel M, Salhotra S, Mabe N, Perez-Atayde A, Vitorino FNL, Garcia B, Gerdemann U, Stegmaier K, Durbin AD, Oldridge DA, Abraham BJ, Look AT.: KAT6A/B inhibition synergizes with retinoic acid and enhances the efficacy of GD2-targeted immunotherapy in neuroblastoma. bioRxiv Jul 2025 Notes: 10.1101/2025.07.01.662644.
b2 Shankar N, Kreiger PA, Oldridge DA, Picarsic J, Arnold MA: Digital Pathology and Artificial Intelligence in Pediatric Pathology 64 Surgical Pathology Clinics Jun 2025 Notes: doi: 10.1016/j.path.2024.11.006.
198 Zhang Y, Abousamra S, Hasan M, Torre-Healy L, Krichevsky S, Shrestha S, Bremer E, Oldridge DA, Rech AJ, Furth EE, Bocklage TJ, Levens JS, Hands I, Durbin EB, Samaras D, Kurc T, Saltz JH, Gupta R: Pathomics Image Analysis of Tumor Infiltrating Lymphocytes (TILs) in Colon Cancer. Res Sq Apr 2025 Notes: doi: 10.21203/rs.3.rs-6173056/v1.
279 Piyadasa H, Oberlton B, Ribi M, Ranek JS, Averbukh I, Leow K, Amouzgar M, Liu CC, Greenwald NF, McCaffrey EF, Kumar R, Ferrian S, Tsai AG, Filiz F, Fullaway CC, Bosse M, Varra SR, Kong A, Sowers C, Gephart MH, Nuñez-Perez P, Yang E, Travers M, Schachter MJ, Liang S, Santi MR, Bucktrout S, Gherardini PF, Connolly J, Cole K, Barish ME, Brown CE, Oldridge DA, Drake RR, Phillips JJ, Okada H, Prins R, Bendall SC, Angelo M: Multi-omic landscape of human gliomas from diagnosis to treatment and recurrence. bioRxiv Apr 2025 Notes: doi: 10.1101/2025.03.12.642624.
1de Barnett Dubensky S, Gallagher M, Kumashie KG, Lu T, Zhu Y, Tedesco J, De Luna N, Premo K, Qi Y, Rachimi S, Cruz Cabrera E, Fulmer F, Meremikwu IC, Carter A, Henrickson SE, Romberg N, Baxter AE, Oldridge DA*, Vella LA*: Multimodal analysis resolves GNG4 as a distinguishing feature of activated germinal center-resident Tfh in humans. Mid-Atlantic Bioinformatics Conference (MABC) 2025 Annual Meeting 2025.
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Selected Publications
119 Lee J, Takemaru L, Bappy DM, Jeong YS, Jeong WK, Oldridge D, Kim D, Ahn S, Lee SH: Adaptive compression framework for giga-pixel whole slide images. Nat Commun Dec 2025 Notes: doi: 10.1038/s41467-025-66889-0.1d5 Dubensky SB, Zhu Y, Gallagher M, Kumashie KG, Lu T, Tedesco J, De Luna N, Premo K, Qi Y, Rachimi S, Cabrera EC, Fulmer B, Meremikwu IC, Carter A, Henrickson SE, Romberg N, Baxter AE, *Oldridge DA, *Vella LA: Multimodal analysis defines GNG4 as a distinguishing feature of germinal center-positioned CD4 T follicular helper cells in humans. bioRxiv Dec 2025 Notes: doi: 10.64898/2025.12.10.693235.
14a Lee J, Leiby JS, Takemaru L, Huang Y, Noh MG, Kim J, Lee B, Lee ME, Oldridge DA, Eun YG, Lee HJ, Lee YC, Kim D: Clinically aligned multi-modal image-text model for pan-cancer prognosis prediction. BioData Min Dec 2025 Notes: doi: 10.1186/s13040-025-00495-0.
238 Piyadasa H, Oberlton B, Ribi M, Leow K, Ranek JS, Averbukh I, Amouzgar M, Liu CC, Franchina DG, Greenwald NF, McCaffrey EF, Kumar R, Ferrian S, Tsai AG, Filiz F, Fullaway CC, Bosse M, Varra SR, Kong A, Sowers C, Gephart MH, Nuñez-Perez P, Yang E, Travers M, Schachter MJ, Liang S, Santi MR, Bucktrout S, Gherardini PF, Connolly J, Cole K, Barish ME, Brown CE, Oldridge DA, Drake RR, Phillips JJ, Okada H, Prins R, Bendall SC, Angelo M: Multi-omic landscape of human gliomas from diagnosis to treatment and recurrence 56 Cancer Cell Dec 2025 Notes: doi: 10.1016/j.ccell.2025.11.006.
15a Mumau MD, Gonzalez MV, Forsyth KS, Pampena MB, Irvine AH, Lavery CLM, Zinski JM, Miller ID, Dubensky SB, Oldridge DA, Vella LA, Betts MR, Fajgenbaum DC: Dysregulated lymphocyte localization in idiopathic multicentric Castleman disease. bioRxiv Dec 2025 Notes: DOI: 10.64898/2025.12.12.693846 14
1cb Weichert-Leahey N, Berezovskaya A, Zimmerman MW, Alvarez-Calderon F, Winschel M, Salhotra S, Mabe N, Perez-Atayde A, Vitorino FNL, Garcia B, Gerdemann U, Stegmaier K, Durbin AD, Oldridge DA, Abraham BJ, Look AT.: KAT6A/B inhibition synergizes with retinoic acid and enhances the efficacy of GD2-targeted immunotherapy in neuroblastoma. bioRxiv Jul 2025 Notes: 10.1101/2025.07.01.662644.
b2 Shankar N, Kreiger PA, Oldridge DA, Picarsic J, Arnold MA: Digital Pathology and Artificial Intelligence in Pediatric Pathology 64 Surgical Pathology Clinics Jun 2025 Notes: doi: 10.1016/j.path.2024.11.006.
198 Zhang Y, Abousamra S, Hasan M, Torre-Healy L, Krichevsky S, Shrestha S, Bremer E, Oldridge DA, Rech AJ, Furth EE, Bocklage TJ, Levens JS, Hands I, Durbin EB, Samaras D, Kurc T, Saltz JH, Gupta R: Pathomics Image Analysis of Tumor Infiltrating Lymphocytes (TILs) in Colon Cancer. Res Sq Apr 2025 Notes: doi: 10.21203/rs.3.rs-6173056/v1.
279 Piyadasa H, Oberlton B, Ribi M, Ranek JS, Averbukh I, Leow K, Amouzgar M, Liu CC, Greenwald NF, McCaffrey EF, Kumar R, Ferrian S, Tsai AG, Filiz F, Fullaway CC, Bosse M, Varra SR, Kong A, Sowers C, Gephart MH, Nuñez-Perez P, Yang E, Travers M, Schachter MJ, Liang S, Santi MR, Bucktrout S, Gherardini PF, Connolly J, Cole K, Barish ME, Brown CE, Oldridge DA, Drake RR, Phillips JJ, Okada H, Prins R, Bendall SC, Angelo M: Multi-omic landscape of human gliomas from diagnosis to treatment and recurrence. bioRxiv Apr 2025 Notes: doi: 10.1101/2025.03.12.642624.
1de Barnett Dubensky S, Gallagher M, Kumashie KG, Lu T, Zhu Y, Tedesco J, De Luna N, Premo K, Qi Y, Rachimi S, Cruz Cabrera E, Fulmer F, Meremikwu IC, Carter A, Henrickson SE, Romberg N, Baxter AE, Oldridge DA*, Vella LA*: Multimodal analysis resolves GNG4 as a distinguishing feature of activated germinal center-resident Tfh in humans. Mid-Atlantic Bioinformatics Conference (MABC) 2025 Annual Meeting 2025.
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5b © The Trustees of the University of Pennsylvania | Site best viewed a in a supported browser. | Site Design: 57 PMACS Web Team. 3 22
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