Faculty

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Derek Alan Oldridge, M.D., Ph.D.

Assistant Professor of Pathology and Laboratory Medicine

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Department: Pathology and Laboratory Medicine

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1f Graduate Group Affiliations 8

Genomics and Computational Biology
Immunology

46 Contact information
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Children's Hospital of Philadelphia
38 Colket Translational Research Building Rm. 9028
3e 3501 Civic Center Boulevard
Philadelphia, PA 19104

Email:
oldridged@chop.edu

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13 Education:
21 a B.A. c
4b Reed College (Interdisciplinary Chemistry/Physics), 2007.
21 a Ph.D. c
58 University of Pennsylvania (Genomics and Computational Biology), 2015.
21 9 M.A. c
5a The Wharton School at the University of Pennsylvania (Statistics), 2015.
21 9 M.D. c
56 Perelman School of Medicine at the University of Pennsylvania, 2017.
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Links
63 The Oldridge Lab Website
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5 3 3 92 Permanent link
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b6 > Perelman School of Medicine > Faculty > Details a

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Description of Clinical Expertise

23 Histocompatibility
16 Immunogenetics
1b Molecular Pathology
19 Clinical Pathology
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Description of Research Expertise

1f Bioinformatics
e Cancer
10 Genomics
12 Immunology
15 Immunotherapy
1a Pediatric Oncology
11 Statistics
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Selected Publications

1cb Weichert-Leahey N, Berezovskaya A, Zimmerman MW, Alvarez-Calderon F, Winschel M, Salhotra S, Mabe N, Perez-Atayde A, Vitorino FNL, Garcia B, Gerdemann U, Stegmaier K, Durbin AD, Oldridge DA, Abraham BJ, Look AT.: KAT6A/B inhibition synergizes with retinoic acid and enhances the efficacy of GD2-targeted immunotherapy in neuroblastoma. bioRxiv Jul 2025 Notes: 10.1101/2025.07.01.662644.

b2 Shankar N, Kreiger PA, Oldridge DA, Picarsic J, Arnold MA: Digital Pathology and Artificial Intelligence in Pediatric Pathology 64 Surgical Pathology Clinics Jun 2025 Notes: doi: 10.1016/j.path.2024.11.006.

198 Zhang Y, Abousamra S, Hasan M, Torre-Healy L, Krichevsky S, Shrestha S, Bremer E, Oldridge DA, Rech AJ, Furth EE, Bocklage TJ, Levens JS, Hands I, Durbin EB, Samaras D, Kurc T, Saltz JH, Gupta R: Pathomics Image Analysis of Tumor Infiltrating Lymphocytes (TILs) in Colon Cancer. Res Sq Apr 2025 Notes: doi: 10.21203/rs.3.rs-6173056/v1.

279 Piyadasa H, Oberlton B, Ribi M, Ranek JS, Averbukh I, Leow K, Amouzgar M, Liu CC, Greenwald NF, McCaffrey EF, Kumar R, Ferrian S, Tsai AG, Filiz F, Fullaway CC, Bosse M, Varra SR, Kong A, Sowers C, Gephart MH, Nuñez-Perez P, Yang E, Travers M, Schachter MJ, Liang S, Santi MR, Bucktrout S, Gherardini PF, Connolly J, Cole K, Barish ME, Brown CE, Oldridge DA, Drake RR, Phillips JJ, Okada H, Prins R, Bendall SC, Angelo M: Multi-omic landscape of human gliomas from diagnosis to treatment and recurrence. bioRxiv Apr 2025 Notes: doi: 10.1101/2025.03.12.642624.

1de Barnett Dubensky S, Gallagher M, Kumashie KG, Lu T, Zhu Y, Tedesco J, De Luna N, Premo K, Qi Y, Rachimi S, Cruz Cabrera E, Fulmer F, Meremikwu IC, Carter A, Henrickson SE, Romberg N, Baxter AE, Oldridge DA*, Vella LA*: Multimodal analysis resolves GNG4 as a distinguishing feature of activated germinal center-resident Tfh in humans. Mid-Atlantic Bioinformatics Conference (MABC) 2025 Annual Meeting 2025.

14f Barnett Dubensky S, Gallagher M, Kumashie KG, Lu T, Zhu Y, Tedesco J, De Luna N, Premo K, Qi Y, Rachimi S, Cruz Cabrera E, Fulmer F, Meremikwu IC, Carter A, Henrickson SE, Romberg N, Baxter AE, Oldridge DA*, Vella LA*: Multimodal analysis resolves GNG4 as a distinguishing feature of a5 activated germinal center-resident T follicular helper cells in humans. American Association of Immunologists (AAI) 2026 Annual Meeting 2025.

158 Zhu, Irina Y., Dubensky, Sam B., Carter, Ashley, Cabrera, Emylette C., Baxter, Amy E., Romberg, Neil D., Oldridge, Derek A.: AI-driven 3D Digital Pathology of Immune Follicular Structures in Human. Mid-Atlantic Bioinformatics Conference (MABC) 2025 Annual Meeting 2025.

1eb Yu WW, Barrett JNP, Tong J, Lin MJ, Marohn M, Devlin JC, Herrera A, Remark J, Levine J, Liu PK, Fang V, Zellmer AM, Oldridge DA, Wherry EJ, Lin JR, Chen JY, Sorger P, Santagata S, Krueger JG, Ruggles KV, Wang F, Su C, Koralov SB, Wang J, Chiu ES, Lu CP.: Skin immune-mesenchymal interplay within tertiarylymphoid structures promotes autoimmunepathogenesis in hidradenitis suppurativa. Immunity 57: 2827-2842, Dec 2024.

278 Wang K, Coutifaris P, Brocks D, Wang G, Azar T, Solis S, Nandi A, Anderson S, Han N, Manne S, Kiner E, Sachar C, Lucas M, George S, Yan PK, Kier MW, Laughlin AI, Kothari S, Giles J, Mathew D, Ghinnagow R, Alanio C, Flowers A, Xu W, Tenney DJ, Xu X, Amaravadi RK, Karakousis GC, Schuchter LM, Buggert M, Oldridge D, Minn AJ, Blank C, Weber JS, Mitchell TC, Farwell MD, Herati RS, Huang AC.: Combination anti-PD-1 and anti-CTLA-4 therapy generates waves of clonal responses that include progenitor-exhausted CD8(+) T cells. Cancer Cell 42: 1582-1597, Sep 2024.

22a Bandyopadhyay S, Duffy MP, Ahn KJ, Sussman JH, Pang M, Smith D, Duncan G, Zhang I, Huang J, Lin Y, Xiong B, Imtiaz T, Chen CH, Thadi A, Chen C, Xu J, Reichart M, Martinez Z, Diorio C, Chen C, Pillai V, Snaith O, Oldridge D, Bhattacharyya S, Maillard I, Carroll M, Nelson C, Qin L, Tan K.: Mapping the cellular biogeography of human bone marrow niches using single-cell transcriptomics and proteomic imaging. Cell 187(12): 3120-3140, Jun 2024 Notes: doi: 10.1016/j.cell.2024.04.013.

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