Eric Stanton Diffenderfer
Eric Stanton Diffenderfer
Associate Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
Department: Radiation Oncology
Graduate Group Affiliations
Contact information
3400 Civic Center Blvd
TRC 2 West
Philadelphia, PA 19104
TRC 2 West
Philadelphia, PA 19104
Publications
Education:
B.S. (Physics)
The Evergreen State College, 2001.
M.S. (Physics)
Florida State University, 2004.
Ph.D. (Nuclear Physics)
Florida State University, 2007.
Permanent linkB.S. (Physics)
The Evergreen State College, 2001.
M.S. (Physics)
Florida State University, 2004.
Ph.D. (Nuclear Physics)
Florida State University, 2007.
Description of Research Expertise
FLASH radiotherapy.Proton SARRP development.
Proton and neutron microdosimetry.
Machine learning applications in Radiation Oncology.
Description of Clinical Expertise
Proton and X-ray therapy physics and dosimetry.Selected Publications
Seyyedeh Azar Oliaei Motlagh, François Vander Stappen, Michele M Kim, Rudi Labarbe, Lucian Hotoiu, Arnaud Pin, Rasmus Nilsson, Erik Traneus, Keith A Cengel, Wei Zou, Boon-Keng Kevin Teo, Lei Dong, Eric S Diffenderfer : Verification of dose and dose rate for quality assurance of spread-out-Bragg-peak proton FLASH radiotherapy using machine log files. Medical Physics April 2025 Notes: DOI: 10.1002/mp.17792.Haiwei Ni, Zachary J Reitman, Wei Zou, Md Naushad Akhtar, Ritama Paul, Menggui Huang, Duo Zhang, Hao Zheng, Ruitao Zhang, Ruiying Ma, Gina Ngo, Lin Zhang, Eric S Diffenderfer, S Azar Oliaei Motlagh, Michele M Kim, Andy J Minn, Jay F Dorsey, Jessica B Foster, James Metz, Constantinos Koumenis, David G Kirsch, Yanqing Gong, Yi Fan : FLASH radiation reprograms lipid metabolism and macrophage immunity and sensitizes medulloblastoma to CAR-T cell therapy. Nature Cancer February 2025 Notes: DOI: 10.1038/s43018-025-00905-6.
Ioannis I Verginadis, Anastasia Velalopoulou, Michele M Kim, Kyle Kim, Ioannis Paraskevaidis, Brett Bell, Seyyedeh Azar Oliaei Motlagh, Antoneta Karaj, Esha Banerjee, Giovanni Finesso, Charles-Antoine Assenmacher, Enrico Radaelli, Jiawei Lu, Yuewei Lin, Mary E Putt, Eric S Diffenderfer, Chandan Guha, Ling Qin, James M Metz, Amit Maity, Keith A Cengel, Constantinos Koumenis, Theresa M Busch : FLASH proton reirradiation, with or without hypofractionation, reduces chronic toxicity in the normal murine intestine, skin, and bone. Radiotherapy and Oncology January 2025 Notes: DOI: 10.1016/j.radonc.2025.110744.
Arpit M. Chhabra MD, Richard A. Amos MSc, FIPEM, Charles B. Simone II, MD, Adeel Kaiser MD, Luis A. Perles PhD, Huan Giap MD, PhD, Christopher L. Hallemeier MD, Jedediah E. Johnson PhD, Haibo Lin PhD, Andrew J. Wroe PhD, Eric S. Diffenderfer PhD, John A. Wolfgang PhD, Hideyuki Sakurai MD, Hsiao-Ming Lu PhD, Theodore S. Hong MD, Eugene J. Koay MD, PhD, Kazuki Terashima PhD, Pavel Vitek PhD, William G. Rule MD, Smith Jim Apisarnthanarax MD, Shahed N. Badiyan MD, Jason K. Molitoris MD, PhD, Michael Chuong MD, Romaine C. Nichols Jr. MD: Proton Beam Therapy for Pancreatic Tumors: A Consensus Statement from the Particle Therapy Cooperative Group Gastrointestinal Subcommittee. International Journal of Radiation Oncology • Biology • Physics 2025 Notes: doi: 10.1016/j.ijrobp.2024.12.020.
Dixin Chen, Seyyedeh Azar Oliaei Motlagh, François Vander Stappen, Rudi Labarbe, Beryl Bell, Michele Kim, Boon‐Keng Kevin Teo, Lei Dong, Wei Zou, Eric Stanton Diffenderfer: Secondary neutron dosimetry for conformal FLASH proton therapy. Medical Physics April 2024 Notes: https://doi-org.proxy.library.upenn.edu/10.1002/mp.17050.
Keith A. Cengel, Michele M. Kim, Eric S. Diffenderfer, Theresa M. Busch: FLASH Radiotherapy: What Can FLASH's Ultra High Dose Rate Offer to the Treatment of Patients With Sarcoma? Seminars in Radiation Oncology 34(2), March 2024 Notes: doi: 10.1016/j.semradonc.2024.02.001.
Georgescu, Andrei, Joseph Hai Oved, Jonathan H. Galarraga, Thomas Cantrell, Samira Mehta, Brian M. Dulmovits, Timothy S. Olson, Pouria Fattahi, Anni Wang, Pelin L. Candarlioglu, Asli Muvaffak, Michele M. Kim, Sezin Aday Aydin, Jeongyun Seo, Eric S. Diffenderfer, Anthony Lynch, G. Scott Worthen, Dan Dongeun Huh : Self-organization of the hematopoietic vascular niche and emergent innate immunity on a chip. Cell Stem Cell 31(12), 2024 Notes: doi: 10.1016/j.stem.2024.11.003.
Uri Amit, Ugur Uslu, Ioannis I Vergiadis, Michele M Kim, Seyyedeh Azar Oliaei Motlagh, Eric S Diffenderfer, Charles-Antoine Assenmacher, Sandra Bicher, Sebastian Atoche, Edgar Ben-Josef, Regina Young, Carl H. June, Constantinos Koumenis : Proton Radiation Boosts Efficacy of Mesothelin-targeting Chimeric Antigen Receptor T Cell Therapy in Pancreatic Cancer. Proceedings of the National Academy of Sciences 2024 Notes: in press.
Kyle Kim, Michele M. Kim, Giorgos Skoufos, Eric S. Diffenderfer, Seyyedeh Azar Oliaei Motlagh, Michail Kokkorakis, Ilektra Koliaki, George Morcos, Khayrullo Shoniyozov, Joanna Griffin, Artemis G. Hatzigeorgiou, James M. Metz, Steven J. Feigenberg, Keith A. Cengel, Bonnie Ky, Costas Koumenis, Ioannis I. Verginadis: FLASH proton radiotherapy mitigates inflammatory and fibrotic pathways and preserves cardiac function in a preclinical mouse model of radiation-induced heart disease. International Journal of Radiation Oncology • Biology • Physics 2024 Notes: in press.
Keith Cengel, Zayne Belal, Michele Kim, Sarah Hagan, Saskia Camps, Alexander Kalinin, Weihow Hsue, Eric Diffenderfer, Adriano Garonna, Cory Tschabrunn: Cardiorespiratory-gated cardiac proton radiotherapy using a novel ultrasound guidance system. Clinical and TRanslational Radiation Oncology 2024 Notes: DOI: 10.1016/j.ctro.2024.100904.