Charles A. Stanley

faculty photo
Emeritus Professor CE of Pediatrics
Senior Physician, Endocrine/Diabetes, Children's Hospital of Philadelphia
Department: Pediatrics

Contact information
Children's Hospital of Philadelphia
34th Street & Civic Center Blvd
Philadelphia, PA 19104
Office: 2155903420
Fax: 2155903053
Education:
B.A. (Biochemical Sciences)
Harvard University, 1964.
M.D. (Medicine)
University of Virginia School of Medicine, 1970.
Post-Graduate Training
Resident in Pediatrics, Children's Hospital of Philadelphia, 1970-1972.
Fellowship in Metabolic Diseases, Children's Hospital of Philadelphia, 1972-1975.
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Description of Research Expertise

genetic disorders of carbohydrate and fatty acid metabolism, insulin secretion

Description of Itmat Expertise

Dr. Stanley conducts research on the disorders of carbohydrate metabolism in children, particularly metabolic and endocrine disorders that cause hypoglycemia, such as genetic forms of congenital hyperinsulinism.

Selected Publications

Zhang T, Chen P, Stanley CA, Hoshi T, Li C.: Mechanisms of octanoic acid potentiation of insulin secretion in isolated islets. Islets 8: 8 - 12, Mar 2019.

Katheryn Grand, Christina Gonzalez-Gandolfi, Amanda Ackerman, Deema Aljeaid, Emma Bedoukian, Lynne M. Bird, Diva DeLeón, Jullianne Diaz, Robert J.Hopkin, Sejal P. Kadakia, Beth Keena, Karen O. Klein, Ian Krantz, Eyby Leon, Katherine Lord, Carey McDougall, Livija Medne, Cara M. Skraban, Charles A. Stanley, Jennifer Tarpinian, Elaine Zackai, Matthew A. Deardorff, Jennifer M. Kalish: Hyperinsulinemic Hypoglycemia in Six Patients with de novo NSD1 Mutations. Am J Medical Genetics 2019 Notes: (in press).

Adzick NS, De Leon DD, States LJ, Lord K, Bhatt TR, Becker SA, Stanley CA: Surgical treatment of congenital hyperinsulinism: Results from 500 pancreatectomies in neonates and children. J Ped Surg 54: 27-32, 2019.

Nassar OM, Li C, Stanley CA, Pettitt BM, Smith TJ: Glutamate dehydrogenase: Structure of a hyperinsulinism mutant, corrections to the atomic model, and insights into a regulatory site. Proteins 87(1): 41-50, Nov 2018.

Adzick NS, De Leon DD, States LJ, Lord K, Bhatti TR, Becker SA, Stanley CA.: Surgical treatment of congenital hyperinsulinism: Results from 500 pancreatectomies in neonates and children. J Pediatr Surg Page: https://doi.org/10.1016/j.jpedsurg.2018.10.030, Oct 2018 Notes: jpedsurg.2018.10.030. [Epub ahead of print]

Tung JY, Boodhansingh K, Stanley CA, De Leon DD: Clinical heterogeneity of hyperinsulinism due to HNF1A and HNF4A mutations. Pediatr Diabetes 19(5): 910-916, Aug 2018.

Srivastava S, Li Z, Soomro I, Sun Y, Wang J, Bao L, Coetzee WA, Stanley CA, Li C, Skolnik EY: Regulation of KATP Channel Trafficking in Pancreatic β Cells by Protein Histidine Phosphorylation. Diabetes Feb 12 2018 Notes: [Epub ahead of print]

Changhong Li, Amanda M. Ackermann, Kara E. Boodhansingh, Tricia R. Bhatti, Chengyang Liu, Jonathan Schug, Nicolai Doliba, Bing Han, Karen E. Cosgrove, Indraneel Banerjee, Franz M. Matschinsky, Itzhak Nissim, Klaus H. Kaestner, Ali Naji, N. Scott Adzick, Mark J. Dunne, Charles A. Stanley and Diva D. De León: Functional and Metabolomic Consequences of ATP-dependent Potassium Channel Inactivation in Human Islets. Diabetes [Epub ahead of print], April 25 2017.

Barrosse-Antle M, Su C, Chen P, Boodhansingh KE, Smith TJ, Stanley CA, De León DD, Li C: A severe case of hyperinsulinism due to hemizygous activating mutation of glutamate dehydrogenase. Pediatric Diabetes Feb 6 (on-line) 2017.

Boodhansingh K, Ferrara C, Stanley CA, et al: Novel Hypoglycemia Phenotype in Congenital Hyperinsulinism Due to Dominant Mutations of Uncoupling Protein 2 (UCP2). The Journal of Clinical Endocrinology & Metabolism Jan 2017 Notes: Accepted for publication.

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Last updated: 10/03/2019
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