Charles A. Stanley

faculty photo
Emeritus Professor CE of Pediatrics
Senior Physician, Endocrine/Diabetes, Children's Hospital of Philadelphia
Department: Pediatrics

Contact information
Children's Hospital of Philadelphia
34th Street & Civic Center Blvd
Philadelphia, PA 19104
Office: 2155903420
Fax: 2155903053
B.A. (Biochemical Sciences)
Harvard University, 1964.
M.D. (Medicine)
University of Virginia School of Medicine, 1970.
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Description of Research Expertise

genetic disorders of carbohydrate and fatty acid metabolism, insulin secretion

Description of Itmat Expertise

Dr. Stanley conducts research on the disorders of carbohydrate metabolism in children, particularly metabolic and endocrine disorders that cause hypoglycemia, such as genetic forms of congenital hyperinsulinism.

Selected Publications

Tung JY, Boodhansingh K, Stanley CA, De Leon DD: Clinical heterogeneity of hyperinsulinism due to HNF1A and HNF4A mutations. Pediatr Diabetes(1), Mar 2018 Notes: [Epub ahead of print]

Srivastava S, Li Z, Soomro I, Sun Y, Wang J, Bao L, Coetzee WA, Stanley CA, Li C, Skolnik EY: Regulation of KATP Channel Trafficking in Pancreatic β Cells by Protein Histidine Phosphorylation. Diabetes Feb 12 2018 Notes: [Epub ahead of print]

Changhong Li, Amanda M. Ackermann, Kara E. Boodhansingh, Tricia R. Bhatti, Chengyang Liu, Jonathan Schug, Nicolai Doliba, Bing Han, Karen E. Cosgrove, Indraneel Banerjee, Franz M. Matschinsky, Itzhak Nissim, Klaus H. Kaestner, Ali Naji, N. Scott Adzick, Mark J. Dunne, Charles A. Stanley and Diva D. De León: Functional and Metabolomic Consequences of ATP-dependent Potassium Channel Inactivation in Human Islets. Diabetes [Epub ahead of print], April 25 2017.

Barrosse-Antle M, Su C, Chen P, Boodhansingh KE, Smith TJ, Stanley CA, De León DD, Li C: A severe case of hyperinsulinism due to hemizygous activating mutation of glutamate dehydrogenase. Pediatric Diabetes Feb 6 (on-line) 2017.

Boodhansingh K, Ferrara C, Stanley CA, et al: Novel Hypoglycemia Phenotype in Congenital Hyperinsulinism Due to Dominant Mutations of Uncoupling Protein 2 (UCP2). The Journal of Clinical Endocrinology & Metabolism Jan 2017 Notes: Accepted for publication.

Kalish JM, Boodhansingh KE, Bhatti TR, Ganguly A, Conlin LK, Becker SA, Givler S, Mighion L, Palladino AA, Adzick NS, De León DD, Stanley CA, Deardorff MA.: Congenital hyperinsulinism in children with paternal 11p uniparental isodisomy and Beckwith-Wiedemann syndrome. J Med Genet 53(1), Jan 2016.

Bhatti T, Ganapathy K, Huppmann A, Conlin L, Boodhansingh S, MacMullen C, Becker S, Ernst L, Adzick NS, Ruchelli A, Ganguly A, Stanley CA: Histologic and Molecular Profile of Peditric Insulinomas: Evidence of a Paternal Parent-of-Origin Effect. Journal of Clinical Endoccrinology & Metabolism Page: jc20152914, Jan 12 2016.

Martin GM, Rex EA, Devaraneni P, Denton JS, Boodhansingh KE, DeLeon DD, Stanley CA, Shyng SL.: Pharmacological Correction of Trafficking Defects in ATP-sensitive Potassium Channels Caused by Sulfonylurea Receptor 1 Mutations. Journal of Biological Chemistry 291(42): 21971-21983, 2016.

Wong SY, Beamer LJ, Gadomski T, Honzik T, Mohamed M, Wortmann SB, Brocke Holmefjord KS, Mork M, Bowling F, Sykut-Cegielska J, Koch D, Ackermann A, Stanley CA, Rymen D, Zeharia A, Al-Sayed M, Marquardt T, Jaeken J, Lefeber D, Conrad DF, Kozicz T, Morava E: Defining the Phenotype and Assessing Severity in Phosphoglucomutase-1 Deficiency. Journal of Pediatrics 175: 130-136, 2016.

Lord K, Radcliffe J, Gallagher PR, Adzick NS, Stanley CA, De León: High Risk of Diabetes and Neurobehavioral Deficits in Individuals With Surgically Treated Hyperinsulinism. J Clin Endocrinol Metab 11(100): 4133-9, Nov 2015.

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Last updated: 04/03/2018
The Trustees of the University of Pennsylvania