Selina M. Luger

faculty photo
Professor of Medicine at the Hospital of the University of Pennsylvania
Attending Physician , Hospital of the University of Pennsylvania
Member , Abramson Cancer Center, University of Pennsylvania
Director, Leukemia Program, Abramson Cancer Center, Perelman School of Medicine
Medical Board, Member, Executive Committee, Hospital of the University of Pennsylvania
Medical Board, President Elect, Hospital of the University of Pennsylvania
Chair, CEQI, Hospital of the University of Pennsylvania
Department: Medicine

Contact information
Division of Hematology Oncology
Perelman Center for Advanced Medicine
12th Floor, South Pavilion
Office #12-101
34th and Civic Center Blvd
Philadelphia, PA 19104
Office: 215-614-1847
Fax: 215-662-4064
Education:
A.B. (Biochemistry)
Harvard University, 1982.
M.D.CM (Medicine)
McGill University, 1987.
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Description of Research Expertise

Leukemia, myelodysplastic syndrome, myeloproliferative disorders
MDS, AML, CML, ALL

Description of Itmat Expertise

Dr. Luger conducts translational research in leukemia, MDS and other hematologic malignancies.

Selected Publications

Tasian SK1, Hurtz C2, Wertheim GB3, Bailey NG4, Lim MS4, Harvey RC5, Chen IM5, Willman CL5, Astles R2, Zebrowski A2, Reshmi SC6, Li MM7, Frey NV2, Luger SM2, Carroll M2, Perl AE2.: High incidence of Philadelphia chromosome-like acute lymphoblastic leukemia in older adults with B-ALL. Leukemia. 31(4): 981-984, Apr 2017

Stock W1,2, Diouf B3,4, Crews KR3,4, Pei D3,5, Cheng C3,5, Laumann K2,6, Mandrekar SJ2,6, Luger S7, Advani A8, Stone RM2, Larson RA1,2, Evans WE3,4.: An Inherited Genetic Variant in CEP72 Promoter Predisposes to Vincristine-Induced Peripheral Neuropathy in Adults With Acute Lymphoblastic Leukemia. Clin Pharmacol Ther. 101(3): 391-395, Mar 2017.

Alexander B Pine,1 Eun-Ju Lee,2 Mikkael Sekeres,3 David P Steensma,4 Daniel Zelterman,5 Thomas Prebet,2 Amy DeZern,6 Rami Komrokji,7 Mark Litzow,8 Selina Luger,9 Richard Stone,4 Harry P Erba,10 Guillermo Garcia-Manero,11 Alfred I Lee,2 Nikolai A Podoltsev,2 Lisa Barbarotta,1 Stephanie Kasberg,1 Jeanne E Hendrickson,12 Steven D Gore,2 and Amer M Zeidan2: Wide Variations in Blood Product Transfusion Practices among Providers Who Care for Patients with Acute Leukemia in the United States. Transfusion 57(2): 289-295, Feb 2017.

Roberts KG1, Gu Z1, Payne-Turner D1, McCastlain K1, Harvey RC1, Chen IM1, Pei D1, Iacobucci I1, Valentine M1, Pounds SB1, Shi L1, Li Y1, Zhang J1, Cheng C1, Rambaldi A1, Tosi M1, Spinelli O1, Radich JP1, Minden MD1, Rowe JM1, Luger S1, Litzow MR1, Tallman MS1, Wiernik PH1, Bhatia R1, Aldoss I1, Kohlschmidt J1, Mrózek K1, Marcucci G1, Bloomfield CD1, Stock W1, Kornblau S1, Kantarjian HM1, Konopleva M1, Paietta E1, Willman CL1, Mullighan CG1.: High Frequency and Poor Outcome of Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia in Adults. J Clin Oncol. 35(4): 394-401, Feb 2017.

Pasquini MC, Zhang MJ, Medeiros BC, Armand P, Hu ZH, Nishihori T, Aljurf MD, Akpek G, Cahn JY, Cairo MS, Cerny J, Copelan EA, Deol A, Freytes CO, Gale RP, Ganguly S, George B, Gupta V, Hale GA, Kamble RT, Klumpp TR, Lazarus HM, Luger SM, Liesveld JL, Litzow MR, Marks DI, Martino R, Norkin M, Olsson RF, Oran B, Pawarode A, Pulsipher MA, Ramanathan M, Reshef R, Saad AA, Saber W, Savani BN, Schouten HC, Ringdén O, Tallman MS, Uy GL, Wood WA Jr, Wirk B, Pérez WS, Batiwalla M, Weisdorf DJ: Hematopoietic Cell Transplantation Outcomes in Monosomal Karyotype Myeloid Malignancies. Biol Blood Marrow Transplant. 22(2): 248-57, Feb 2016

Zhang J1, McCastlain K2, Yoshihara H2, Xu B1, Chang Y2, Churchman ML2, Wu G1, Li Y1, Wei L1,2, Iacobucci I2, Liu Y1, Qu C1, Wen J1, Edmonson M1, Payne-Turner D2, Kaufmann KB3, Takayanagi SI3,4, Wienholds E3, Waanders E2,5, Ntziachristos P6, Bakogianni S6, Wang J6, Aifantis I6,7, Roberts KG2, Ma J2, Song G2, Easton J1, Mulder HL1, Chen X1, Newman S1, Ma X1, Rusch M1, Gupta P1, Boggs K1, Vadodaria B1, Dalton J2, Liu Y2, Valentine ML8, Ding L9, Lu C9, Fulton RS9, Fulton L9, Tabib Y9, Ochoa K9, Devidas M10, Pei D11, Cheng C11, Yang J12, Evans WE12, Relling MV12, Pui CH13, Jeha S13, Harvey RC14, Chen IL14, Willman CL14, Marcucci G15, Bloomfield CD16, Kohlschmidt J16, Mrózek K16, Paietta E17, Tallman MS18, Stock W19, Foster MC20, Racevskis J21, Rowe JM22, Luger S23, Kornblau SM24, Shurtleff SA2, Raimondi SC2, Mardis ER9, Wilson RK9, Dick JE3, Hunger SP25, Loh ML26, Downing JR2, Mullighan CG2; St. Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project.: Deregulation of DUX4 and ERG in acute lymphoblastic leukemia. Nat Genet. 48(12): 1481-1489, Dec 2016.

Ganzel C, Manola J, Douer D, Rowe JM, Fernandez HF, Paietta EM, Litzow MR, Lee JW, Luger SM, Lazarus HM, Cripe LD, Wiernik PH, Tallman MS: Extramedullary Disease in Adult Acute Myeloid Leukemia Is Common but Lacks Independent Significance: Analysis of Patients in ECOG-ACRIN Cancer Research Group Trials, 1980-2008. J Clin Oncol. 34(29): 3544-3553, Oct 2016.

Kumar AJ, Gimotty PA, Gelfand J, Buck G, Rowe JM, Goldstone AH, Fielding A, Marks DI, Litzow M, Paietta E, Lazarus HM, Tallman MS, Luger SM, Loren AW.: Delays in Post-Remission Chemotherapy for Philadelphia Chromosome Negative Acute Lymphoblastic Leukemia are Associated with Inferior Outcomes in Patients who Undergo Allogeneic Transplant: An Analysis from ECOG 2993/MRC UK ALLXII. Am J Hematol. Jul 2016.

Li S1, Garrett-Bakelman FE2, Chung SS3, Sanders MA4, Hricik T3, Rapaport F3, Patel J3, Dillon R5, Vijay P6, Brown AL7,8,9, Perl AE10, Cannon J10, Bullinger L11, Luger S10, Becker M12, Lewis ID7,9,13, To LB9,13, Delwel R4, Löwenberg B4, Döhner H11, Döhner K11, Guzman ML2, Hassane DC2, Roboz GJ2, Grimwade D5, Valk PJ4, D'Andrea RJ7,8,9, Carroll M10, Park CY14,15, Neuberg D16, Levine R3, Melnick AM2, Mason CE1,17.: Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia. Nat Med. 22(7): 792-9, Jul 2016.

Luskin MR, Carroll M, Lieberman D, Morrissette JJ, Zhao J, Crisalli L, Roth DB, Luger SM, Porter DL, Reshef R.: Clinical Utility of Next Generation Sequencing for Oncogenic Mutations in AML Patients Undergoing Allogeneic Stem Cell Transplantation. Biol Blood Marrow Transplant. Jul 2016.

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Last updated: 07/19/2017
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