Sydney M. Evans

faculty photo
Professor of Radiation Oncology
Education Officer, University of Pennsylvania School of Medicine Department of Radiation Oncology
Vice Chair, Faculty Affairs, University of Pennsylvania, School of Medicine, Department of Radiation Oncology
Department: Radiation Oncology

Contact information
187 John Morgan Building
3620 Hamilton Walk
Philadelphia, PA 19104
Office: 215-898-0074
BS (Pre-Veterinary Medicine)
Rutgers University, Douglas College, 1973.
VMD (Veterinary Medicine)
University of Pennsylvania, School of Veterinary Medicine , 1977.
MS (Comparative Medical Sciences)
University of Pennsylvania, School of Veterinary Medicine , 1986.
Permanent link

Description of Research Expertise

Measuring hypoxia in vivo
Animal Models of human disease
Cancer physiology, proliferation
Cancer physiology, tumor vasculature

Description of Other Expertise

Mentoring junior faculty
Mentoring women

Description of Itmat Expertise

Dr. Evans is investigating factors that cause the resistance of tumors to therapy, in particular hypoxia in human cancers.

Selected Publications

Sood, N Jenkins, WT Yang, X-Y Shah, NN Katz, JS Koch, CJ Frail, PR Therein, MJ Hammer, DA Evans, SM: Biodegradable polymersomes for the delivery of Gemcitabine to Panc-1 cells. Journal of Pharmaceutics (on line). Hindawi Publishing Company, 2013(932797), 2013.

Koch CJ, Jenkins WT, Jenkins KW, Yang XY, Shuman AL, Pickup S, Riehl1 CR, Paudya R, Poptani H, Evans SM: Mechanisms of Blood Flow and Hypoxia Production in Rat 9L Epigastric Tumors. Tumor Microenvironment and Therapy 1(1): 1-13, Dec 2012.

Lilie L Lin, LL Antti Silvoniemi James B Stubbs Ramesh Rengan Sami Suilamo Olof Solin Chaitanya Divgi Olli Eskola Jonathan M. Sorger Michael G. Stabin Alexander Kachur Stephen M. Hahn Tove Grönroos Sarita Forsback Sydney M Evans Cameron J. Koch Heikki Minn: Radiation Dosimetry and Biodistribution of the Hypoxia Tracer 18F-EF5 in Oncologic Patients. Cancer Biotherapy & Radiopharmaceuticals 27(7): 412-9, Sep 2012.

Marotta D, Karar J, Jenkins WT, Kumanova M, Tobias JW, Baldwin D, Hadjigeorgiou A, Alexiou P, Evans SM, Alarcon R, Maity A, Koch CJ, Koumenis C: In vivo profiling of hypoxic gene expression in gliomas using the hypoxia marker EF5 and laser-capture microdissection. Cancer Research (eds.). 71(3): 779-89, Feb 2011

Evans SM, Jenkins KW, Chen HI, Jenkins WT, Judy KD, Hwang W-T, Lustig RA, Judkins AR, Grady MS, Hahn SM, Koch CJ: The Relationship among Hypoxia, Proliferation, and Outcome in Patients with De Novo Glioblastoma: A Pilot Study. Translational Oncology 3(3): 160–9, Jun 1 2010

Koch CJ, Scheuermann JS, Divgi C, Judy KD, Kachur A, Freifelder R, Saffer J, Karp J, Stubbs JM, Hahn SM, Driesbaugh J, Smith D, Prendergast S, Evans SM: Biodistribution and dosimetry of 18F-EF5 in cancer patients with preliminary comparison of 18F-EF5 uptake versus EF5 binding in human glioblastoma. European Journal of Nuclear medicine and Molecular Imaging 37(11): 2048-59, Nov 2010.

Koch CJ, Shuman AL, Jenkins WT, Kachur AV, Karp JS, Freifelder R, Dolbier WR, Evans SM: The radiation response of cells from 9L gliosarcoma tumors is correlated with [F18]-EF5 uptake. International Journal of Radiation Biology 85(12): 1137-47, Dec 2009

Cerniglia G, Pore N, Tsai JH, Schultz S, Mick R, Regine C, Xiaoman X, Durduran T, Yodh AG, Evans SM, Koch CJ, Hahn SM, Quon H, Sehgal CM, Lee W M-F, Maity A: Epidermal growth factor inhibition modulates the microenvironment by vascular normalization to improve chemotherapy and radiotherapy efficacy. PloS one 4(8): e6539, Aug 2009.

Komar G, Seppänen M, Eskola O, Lindholm Paula, Grönroos T, Forsback S, Sipilä H, Evans SM, Solin O, Minn H: 18F-EF5: A new PET tracer for imaging hypoxia in head and neck cancer. Journal of Nuclear Medicine 49(12): 1944-51, Dec 2008.

Evans, SM, Jenkins KW, Jenkins WT, Dilling T, Judy KD, Schrlau A, Judkins A, Hahn SM, Koch CJ: Imaging and analytical methods as applied to the evaluation of vasculature and hypoxia in human brain tumors. Radiation Research 170(6): 677-90, Dec 2008.

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Last updated: 10/29/2014
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