Claire H. Mitchell

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Associate Professor of Anatomy & Cell Biology
Department: Anatomy & Cell Biology

Contact information
440 Levy Bldg
240 S. 40th St
Philadelphia, PA 19104
Office: (215) 573-2176
Graduate Group Affiliations
B.Sc. (Biology)
McGill University, Montreal, Canada, 1986.
Ph.D. (Single Ion Channels )
Institute of Ophthalmology, University College London, U.K., 1994.
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Description of Research Expertise

My research is concerned with the basic physiological mechanisms that interfere with the survival of neurons, astrocytes and epithelial cells as we age.

Description of Itmat Expertise

Purinergic signaling, lysospmal function, cytokine release, mechanosensitive signals, glaucoma models, macular degeneration, cell based screening assays

Selected Publications

Loov C, Mitchell CH, Simonsson M, Erlandsson A: Slow degradation in phagocytic astrocytes can be enhanced by lysosomal acidification. Glia 63(11): 1997-2009, 2015.

Frost LS, Lopes VS, Bragin A, Reyes-Reveles J, Brancato J, Cohen A, Mitchell CH, Williams DS, Boesze-Battaglia K.: The contribution of melanoregulin to microtubule-associated protein 1 light chain 3 (LC3) associated phagocytosis in retinal pigment epithelium. Molecular Neurobiology 52(3): 1135-1151, 2015.

Beckel JM, Daugherty SL, Tyagi P, Wolf-Johnston AS, Birder LA, Mitchell CH, de Groat WC: Pannexin 1 channels mediate the release of ATP into the lumen of the rat urinary bladder. Journal of Physiology 593(8): 1857-1871, 2015.

Lu W, Hu HL, Sevigny J, Gabelt BT, Kaufman PL, Johnson EC, Morrison JC, Zode GS, Sheffield VC, Zhang XL, Laties AM, Mitchell CH: Rat, mouse, and primate models of chronic glaucoma show sustained elevation of extracellular ATP and altered purinergic signaling in the posterior eye. Investigative Ophthalmology and Visual Science 56(5): 3075-3083, 2015.

Maguire SE, Rhoades S, Chen WF, Sengupta A, Yue ZF, Lim JC, Mitchell CH, Weljie AM, Sehgal A: Independent effects of gamma-aminobutyric acid transaminase (GABAT) on metabolic and sleep homeostasis. Journal of Biological Chemistry 290(33): 20407-20416, 2015.

Lee JH, McBrayer MK, Wolfe DM, Haslett LJ, Kumar A, Sato Y, Lie PPY, Mohan P, Coffey EE, Kompella U, Mitchell CH, Lloyd-Evans E, Nixon RA: Presenilin 1 maintains lysosomal Ca2+ homeostasis via TRPML1 by regulating vATPase-mediated lysosome acidification. Cell Reports 12(9): 1430-1444, 2015.

Tordoff MG, Aleman TR, Ellis HT, Ohmoto M, Matsumoto I, Shestopalov VI, Mitchell CH, Foskett JK, Poole RL: Normal taste acceptance and preference of PANX1 knockout mice. Chemical Senses 40(7): 453-459, 2015.

Guha, S, Liu, J, Baltazar, G, Laties, AM, Mitchell, CH: Rescue of compromised lysosomes enhances degradation of photoreceptor outer segments and reduces lipofuscin-like autofluorescence in retinal pigmented epithelial cells. Advances in Experimental Medicine and Biology 801: 105-111, 2014.

Beckel JM, Argall AJ, Lim JC, Xia J, Lu W, Coffey EE, Macarak EJ, Shahidulla M, Delamere NA, Zode GS, Sheffield VC, Shestopalov VI, Laties AM, Mitchell CH: Mechanosensitive release of ATP through pannexin channels and mechanosensitive upregulation of pannexin channels in optic nerve head astrocytes: a mechanism for purinergic involvement in chronic strain. Glia 62(9): 1486-1501, 2014.

Coffey EE, Beckel JM, Laties AM, Mitchell CH: Lysosomal alkalization and dysfunction in human fibroblasts with the Alzheimer's disease-linked presenilin 1 A246E mutation can be reversed with cAMP. Neuroscience 263: 111-124, 2014.

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Last updated: 10/17/2016
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